A5101654018- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Biochemical effects in animals
- Cardiac electrophysiology and arrhythmias
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Plant-based Medicinal Research
- Neurological Disease Mechanisms and Treatments
- Advanced Chemical Sensor Technologies
- Neurotransmitter Receptor Influence on Behavior
Dalian Medical University
2023
First Affiliated Hospital of Dalian Medical University
2023
University of Cincinnati
2012
Central South University
2011
Institute of Neurobiology
2007
Xi'an Jiaotong University
2006-2007
National Natural Science Foundation of China
2006
Shaanxi Provincial People's Hospital
2006
Shanxi Medical University
2006
Second Affiliated Hospital of Xi'an Jiaotong University
2006
Background Activation of N-methyl-D-aspartate (NMDA) receptors and alpha-amino-3-hydroxy-5-methyl4-isoxazole-propionic acid (AMPA) play an important role in the neurons death induced by ischemia. The mitigating effect intravenous anesthetics on ischemic neuron injury is related to their influence NMDA receptors. This study was performed investigate ketamine-midazolam anesthesia AMPA receptor subunits expression peri-infarction rat brain explore its potential mechanism neuroprotection....
Neuronal nitric oxide synthase (nNOS) regulates neurogenesis in the normal developing brain, but role of nNOS adult ischemic brain remains unclear. The aim this study was to investigate temporal and spatial relationship between cell migration from ependymal/subventricular zone (SVZ) peri‐infarction expression rat. Ependymal/subventricular cells were prelabeled with fluorescence dye DiI. Focal cerebral ischemia induced by occlusion left middle artery. At 1, 3, 7, 14 21 days after ischemia,...
To explore the related neurobiochemical mechanism by comparing concentration change of dopamine (DA), dihydroxy-phenyl acetic acid (DOPAC), glutamate (Glu), and γ-aminobutyric (GABA) in brain tissues schizophrenia (SZ) developmental model rats chronic medication rats.A total 60 neonatal male Spragur-Dawley (SD) were randomly assigned to 3 groups at postnatal day 6: an SZ rat group (subcutaneous injection with MK-801 7-10, 0.1 mg/kg, Bid), a (intraperitoneal 47-60, 0.2 mg/kg,Qd), normal...
High‐ and low‐alcohol sensitivity (HAS US) rats have been selected for their differences in ethanol‐induced sleep time. The also differ to pentobarbital, halothane, isoflurane, enflurane. To determine if this extended propofol, the anesthetic requirements were measured. In study, time tissue levels of propofol at awakening, as well pharmacokinetics, evaluated. Propofol was administered intravenously. For one group rats, times measured; blood brain samples taken awakening. Blood collected...
Background The purpose of this study was to investigate the molecular mechanisms and material basis Huangqi Guizhi Wuwu Decoction (HGWD) in treating clinical Ischemic stroke (IS) using network pharmacology docking techniques. Materials Methods retrieved screened practical components HGWD from TCMSP, BATMAN-TCM, ETCM databases. Target prediction performed SwissTargetPrediction database, disease targets for IS were obtained Gene Cards, DisGeNET, OMIM regulatory by VENN analysis,...