A5101908407- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Wound Healing and Treatments
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Burn Injury Management and Outcomes
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
- Artificial Immune Systems Applications
- Diabetic Foot Ulcer Assessment and Management
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Network Security and Intrusion Detection
- Genomics and Phylogenetic Studies
- Metastasis and carcinoma case studies
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Bone Tissue Engineering Materials
- Silk-based biomaterials and applications
- Anomaly Detection Techniques and Applications
- Advanced Glycation End Products research
Sichuan University
2014-2025
West China Hospital of Sichuan University
2022-2025
Central China Normal University
2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
China Pharmaceutical University
2018-2022
National Center for Drug Screening
2022
Second Affiliated Hospital of Zhejiang University
2011-2021
Handan College
2021
Chongqing University
2021
Diagnosing lung cancer from indeterminate pulmonary nodules (IPLs) remains challenging. In this multi-institutional study involving 2032 participants with IPLs, we integrate the clinical, radiomic circulating cell-free DNA fragmentomic features in 5-methylcytosine (5mC)-enriched regions to establish a multiomics model (clinic-RadmC) for predicting malignancy risk of IPLs. The clinic-RadmC yields an area-under-the-curve (AUC) 0.923 on external test set, outperforming single-omics models, and...
Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ via selective quenching of reactive oxygen species. This study investigated the potential protective effects hydrogen against severe burn-induced early AKI rats.Severe burn were induced immersing shaved back rats into 100°C bath for 15 s. Fifty-six Sprague-Dawley randomly divided Sham, Burn + saline, and hydrogen-rich saline (HS) groups,...
V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel inhibitory immune checkpoint molecule. Vsir
Abstract The rhesus macaque is a prime model animal in neuroscience. A comprehensive transcriptomic and open chromatin atlas of the brain key to deeper understanding brain. Here we characterize transcriptome 416 samples from 52 regions 8 brains. We identify gene modules associated with specific like cerebral cortex, pituitary, thalamus. In addition, discover 9703 novel intergenic transcripts, including 1701 coding transcripts 2845 lncRNAs. Most are only expressed or cortical individuals....
Immunotherapies targeting CTLA-4 and PD-1 have elicited promising responses in a variety of cancers. However, the relatively low response rates warrant identification additional immunosuppressive pathways. V domain immunoglobulin suppressor T cell activation (VISTA) plays critical role antitumor immunity is valuable target cancer immunotherapy.Here, we used single-cell RNA-seq to analyze gene expression levels 14897 cells from breast sample its paired 7,320 normal cells. Then, validated...
Abstract Background Lung cancer is one of most common cancers worldwide, with a 5-year survival rate less than 20%, which mainly due to late-stage diagnosis. Noninvasive methods using 5-hydroxymethylation cytosine (5hmC) modifications and fragmentation profiles from 5hmC cell-free DNA (cfDNA) sequencing provide an opportunity for lung detection management. Results A total 157 patients were recruited generate the largest cfDNA dataset, consisted 62 adenocarcinoma (LUAD), 48 squamous cell...
Diagnosing lung cancer at a curable stage offers the opportunity for favorable prognosis. The emerging epigenomics analysis on plasma cell-free DNA (cfDNA), including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications, has acted as promising approach facilitating identification of cancer. And, integrating 5mC biomarker with chest computed tomography (CT) image features could optimize diagnosis cancer, exceeding performance models built single feature. However, clinical...
Abstract Background The high lethal rate of pancreatic cancer is partly due to a lack efficient biomarkers for screening and early diagnosis. We attempted develop effective noninvasive methods using 5-methylcytosine (5mC) 5-hydroxymethylcytosine (5hmC) markers from circulating cell-free DNA (cfDNA) the detection ductal adenocarcinoma (PDAC). Results A 24-feature 5mC model that can accurately discriminate PDAC healthy controls (area under curve (AUC) = 0.977, sensitivity 0.824, specificity 1)...
A multiple-mouse solenoidal MR coil was developed for in vivo imaging of up to 13 mice simultaneously screen tumors on a 1.5 T clinical scanner. For the be effective as screening tool, it should permit acquisition MRIs which orthotopic with diameters >2 mm are detectable reasonable period time (<1 hr magnet time) and their sizes accurately measured. Using spin echo sequence, we demonstrated that this provides sufficient sensitivity moderately high resolution images (156-176 microm...
The emergence of skin substitutes provides a new approach for the treatment wound repair and healing. consistent steady release angiogenic factors is an important factor in promotion angiogenesis substitutes, which usually lack, yet need, vascular network. In this study, ginsenoside Rg1, natural compound isolated from Panax notoginseng (PNS), was incorporated into collagen/chitosan-gelatin microsphere (CC-GMS) scaffold. cumulative kinetics were evaluated, effects released Rg1 on human...
Abstract Background Cancer immunotherapy has gained increasing popularity as a novel approach to treat cancer. A member of the B7 family, V-domain immunoglobulin suppressor T-cell activation (VISTA) is immune checkpoint that regulates broad spectrum responses. VISTA an acidic pH-selective ligand for P-selectin glycoprotein ligand-1(PSGL-1). CA-170, first-in-class small-molecule dual antagonist VISTA/PD-L1, was collaboratively developed by Aurigene Discovery Technologies Limited and Curis,...
Using epigenetic markers and fragmentomics of cell-free DNA for cancer detection has been proven applicable.We further investigated the diagnostic potential combining two features (epigenetic fragmentomic information) detecting various types cancers. To do this, we extracted cfDNA from 191 whole-genome sequencing data studied them in 396 low-pass 5hmC data, which included four common control samples.In our analysis samples, observed aberrant ultra-long fragments (220-500 bp) that differed...