A5100357822- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Ferroptosis and cancer prognosis
- Medical Imaging and Pathology Studies
- Endoplasmic Reticulum Stress and Disease
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Science, Research, and Medicine
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
Shanghai Pulmonary Hospital
2025
Tongji University
2025
Shanghai First Maternity and Infant Hospital
2024
Jiaxing University
2024
Defence Electronics Research Laboratory
2020
Shanghai Jiao Tong University
2013
Diagnosing lung cancer from indeterminate pulmonary nodules (IPLs) remains challenging. In this multi-institutional study involving 2032 participants with IPLs, we integrate the clinical, radiomic circulating cell-free DNA fragmentomic features in 5-methylcytosine (5mC)-enriched regions to establish a multiomics model (clinic-RadmC) for predicting malignancy risk of IPLs. The clinic-RadmC yields an area-under-the-curve (AUC) 0.923 on external test set, outperforming single-omics models, and...
Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding "invagination" and "metaplasia" theories. The endometrial-myometrial junction (EMJ) connects the endometrium myometrium important for diagnosing classifying adenomyosis, but its in-depth study just beginning. Using single-cell RNA sequencing spatial profiling, we mapped transcriptional alterations across eutopic endometrium, lesions, EMJ. Within identified unique epithelial...
Diagnosing lung cancer at a curable stage offers the opportunity for favorable prognosis. The emerging epigenomics analysis on plasma cell-free DNA (cfDNA), including 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) modifications, has acted as promising approach facilitating identification of cancer. And, integrating 5mC biomarker with chest computed tomography (CT) image features could optimize diagnosis cancer, exceeding performance models built single feature. However, clinical...
The aim of the study was to evaluate use F-fluorodeoxyglucose ((18)F-FDG) PET/computed tomography (CT) in follow-up and clinical management ovarian cancer patients after therapy.A total 152 who had undergone therapy were evaluated. Clinical information, CA-125 levels, traditional imaging findings analyzed. According indication for PET/CT divided into five groups assessing role (18)F-FDG therapy. A comparison made between results follow-up.Of patients, 137 15 lost follow-up. 105 found have...
Abstract Hepatocellular carcinoma (HCC) is the predominant pathological type of liver cancer with an unfavorable prognosis. Disulfidptosis newest cell death form and plays a vital role in tumorigenesis. However, disulfidptosis-related genes (DRGs) HCC remains unknown. The RNA-seq clinical data patients were obtained from Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Based on DRGs TCGA cohort, predictive model was established via regression analysis least absolute...