A5003971381- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Pharmacological Effects of Natural Compounds
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Genetic and Kidney Cyst Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Hypertrophic osteoarthropathy and related conditions
- Bone health and osteoporosis research
- Hepatitis C virus research
- Connective tissue disorders research
- Immune Cell Function and Interaction
- Probabilistic and Robust Engineering Design
- Advanced Glycation End Products research
- Bone and Dental Protein Studies
- Pancreatic function and diabetes
- Trace Elements in Health
- Hepatitis B Virus Studies
- Bone health and treatments
- Gout, Hyperuricemia, Uric Acid
- Dermatological and Skeletal Disorders
- Endoplasmic Reticulum Stress and Disease
- Diabetes Treatment and Management
University of Electronic Science and Technology of China
2020-2025
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2023
Chinese Academy of Sciences
2022
State Nuclear Power Technology Company (China)
2021
Chronic kidney disease (CKD) is closely linked to the aging process, making identification of protein biomarkers that reflect in specific organs and tissues crucial for a deeper understanding this phenomenon. This study aimed identify potential aging-related proteins present urine CKD patients. Utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis, we identified total 1,712 samples from both healthy controls patients our discovery cohort. Among 845...
Podocyte injury plays a critical role in the pathogenesis and progression of focal segmental glomerulosclerosis (FSGS). Transmembrane protein 30A (TMEM30A) downregulation participates podocyte injury. This study aimed to identify pathways molecules associated with TMEM30A context FSGS In our study, we found marker Synaptopodin were significantly downregulated kidney tissues from patients compared those normal controls. Using transcriptomic metabolomic analyses, characterized Tmem30a...
Septic acute kidney injury (AKI) is commonly associated with renal dysfunction and high mortality in patients. Owing to the rapid violent occurrence of septic AKI inflammation, there are no effective therapies clinically treat it. Embelin, a natural product, has potential regulatory role immunocytes. However, mechanism embelin remains unknown. This study aimed elucidate macrophage regulation lipopolysaccharide (LPS)-induced AKI. Embelin was intraperitoneally administered mice after LPS...
Background and objectives The activated complement profile in IgA nephropathy (IgAN) is still unclear. Our study investigated the of urinary complements IgAN patients its correlations with clinical pathological characteristics. Methods Urinary protein abundance was detected by liquid chromatography-tandem mass spectrometry (LC–MS/MS) 50 IgAN, membranous (MN), 68 healthy controls (HC). Then, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses were performed to identify...
Abstract Occult hepatitis B virus infection (OBI) is characterized by the presence of HBV DNA in absence detectable HBsAg. OBI an important risk factor for cirrhosis and hepatocellular carcinoma, but its pathogenesis has not been fully elucidated. Mutations preS/S genes can lead to impaired secretion either HBsAg or S-protein resulting accumulation defective viruses S protein cells. In our previous work, M133S mutation was present gene maintenance hemodialysis (MHD) patients with OBI. this...
Highlights•Tmem30a was downregulated in FSGS patients and ADR-induced podocyte injury models•Loss of Tmem30a expression induces by activating pyroptosis•MCC950 DSF alleviates inhibiting pyroptosisSummaryPodocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized can easily progress to end-stage kidney disease. However, the mechanisms underlying remain unclear. We observed along with pyroptosis FSGS. Bioinformatic analysis public datasets revealed that transmembrane...
Vascular calcification is prominent in patients with chronic kidney disease (CKD) and a strong predictor of cardiovascular mortality the CKD population. However, mechanism underlying CKD-associated vascular remains unclear. To identify potential therapeutic targets, 5/6 nephrectomy rat model was established by feeding high-phosphorous diet as group compared sham rats at 4 16 weeks. Sequencing analyses aorta revealed 643 upregulated 1023 downregulated genes weeks, well 899 1185 weeks to...
Chronic kidney disease (CKD) has recently become a serious health and social concern. Vascular calcification, common complication of CKD, is risk factor that increases the incidence mortality cardiovascular events in patients with CKD. However, there are currently no effective therapeutic targets can facilitate treatment fewer side effects for vascular calcification To identify potential targets, we performed label-free quantification (LFQ) analyses protein samples from rat aortic smooth...
Objective: The pathogenesis of renal osteopathy and cardiovascular disease suggests the disordered bone-vessel axis in chronic kidney disease-mineral bone disorder (CKD-MBD). However, mechanism CKD-MBD remains unclear.Methods: We established a rat model to observe pathophysiological phenotype performed RNA sequencing aortas identify novel targets CKD-MBD.Results: microarchitecture femoral trabecular deteriorated alveolar loss was aggravated rats. intact parathyroid hormone alkaline...
The reliability analysis of nuclear power conventional island instrument supply system is an important part the research unit. Aiming at structural characteristics meter system, method based on Monte Carlo-dynamic fault tree proposed. According to component composition and connection logic dynamic model established Carlo simulation used calculate probability importance index each suggestions for improving are results show that can effectively accurately quantitatively analyze has strong...
Abstract Septic acute kidney injury (AKI) mainly results in life-threatening renal dysfunction involving tubular to bring heavy burden patients intensive care unit (ICU). However, there is still a lack of therapy prevent septic AKI effectively and inexpensive. To observe the role novel mechanism isoliquiritigenin (ISL) which isolated from roots licorice AKI, we used LPS induce upon both vitro vivo. 50mg/kg ISL 5 mg/kg Ferrostatin-1 were once given male C57BL/6 mice one hour before 1 i.p...
The kidney reabsorbs large amounts of glucose through Na+-glucose cotransporter 2 (SGLT2). P4-ATPase acts together with the β-subunit TMEM30A to mediate asymmetric distribution phosphatidylserine (PS), phosphatidylethanolamine (PE), and other amino phospholipids, promoting plasma membrane internal vesicle fusion, facilitating protein transport. We observed reduced expression in renal tubules DKD IgA patients, suggesting a potential role tubular cells. To investigate tubules, we constructed...