A5103031951- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Appendicitis Diagnosis and Management
- Hemodynamic Monitoring and Therapy
- Helicobacter pylori-related gastroenterology studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Cells and Metastasis
- Kruppel-like factors research
- Cancer-related gene regulation
- Intraperitoneal and Appendiceal Malignancies
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Histone Deacetylase Inhibitors Research
- Surgical Sutures and Adhesives
- Tuberous Sclerosis Complex Research
- Neuroblastoma Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Surgical site infection prevention
- Neurofibromatosis and Schwannoma Cases
- Cancer Diagnosis and Treatment
Chosun University Hospital
2024
Hallym University
2005-2023
Kangdong Sacred Heart Hospital
2010-2023
Weatherford College
2021
Sidney Kimmel Comprehensive Cancer Center
2020
Yonsei University
2007-2009
Severance Hospital
2007
<i>Background:</i> Gastric signet ring cell carcinoma (SRC) is a histological type based on microscopic characteristics and not biological behavior. This study compared the clinicopathological features prognosis of advanced SRC with non-signet adenocarcinoma (NSRC) stomach. <i>Methods:</i> We reviewed records 4,759 consecutive patients diagnosed gastric who were resected surgically from 1987 to 2003. Of these, 662 (13.9%) had 4,097 NSRC. <i>Results:</i>...
Purpose: Conventional three-port laparoscopic appendectomy (LA) is more commonly performed than transumbilical single port (TUSPLA). In this report, we a prospective randomized study comparing the outcomes of LA and TUSPLA. Methods: Between April 14, 2009 June 10, 2009, 40 patients who required appendectomies were randomly selected to receive either TUSPLA or LA. None these had perforation abscess. Twenty received other 20 The clinical visual analog pain scores (VAS) compared between groups....
The delta neutrophil index (DNI) represents the fraction of circulating immature granulocytes and is a marker infection sepsis. Our objective was to evaluate usefulness DNI for predicting in-hospital mortality within 30 days after surgery in patients with sepsis caused by peritonitis means comparing DNI, white blood cell (WBC) count, percentage, C-reactive protein (CRP) before surgery.We performed retrospective analysis demographic, clinical, laboratory data. WBC CRP were measured surgery,...
Abstract BACKGROUND. The incidence of lymph node metastasis is high in patients who have pT3 gastric cancer. However, the impact total retrieved nodes (tLNs) on staging and survival these not clear. METHODS. For this study, authors examined 1895 with cancer underwent surgery at Yonsei University Medical College from January 1987 to June 2000. RESULTS. Four hundred sixty (24.3%) were diagnosed pT3N0 Patients had < 31 tLNs (25th percentile) less advanced (N) stage than other ( P .001)....
Although many studies have demonstrated improvements in short-and long-term outcomes of gastric cancer surgery, changes survival over time are not well-established. This study was conducted to evaluate host, tumor, and treatment factors patients treated at a single institution period 45-yr.We retrospectively evaluated 9282 with from 1955 1999, divided the 45-yr into 4 frames based on published articles: 1962 (n=228), 1963 1972 (n=891), 1973 1988 (n=2789), 1989 1999 (n=5374).Remarkable were...
Value of Nonvisualized Primary Lesions Gastric Cancer on Preoperative MDCTJeong-Sik Yu1, Seung Ho Choi2, Won Hyuk Jae-Joon Chung1, Joo Hee Kim1 and Ki Whang Kim1Audio Available | Share
For patients with primary, localized gastrointestinal stromal tumors (GIST), surgery complete excision is the treatment of choice. 1 However, more than half experience tumor recurrence during course their disease, 2 and resection can be achieved only in less these who had tumors.Recently, imatinib has been applied unresectable or recurrent GISTs, resulting improved patient survival.4][5][6] Moreover, results cytoreductive far advanced metastatic GISTs are treated also rare.Herein, we report...
Background/Aims The tumor-node-metastasis (TNM) staging is an useful system to assess the prognosis of any solid cancer. As new TNM classification 7th stomach cancer was revised in 2009, we evaluated prognostic predictability International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) compared 6th UICC/AJCC gastric Methods From January 2000 December 5-year survival rates 266 patients with were calculated by and classification. Results Using classification, there no...
Abstract Background The grouping of patients who have a poor prognosis is important in determining treatment strategy. aim this study was to investigate the clinicopathologic features and with perinodal extension, focus on difference survival between homogenous groups. Methods This included total 1,092 underwent curative gastrectomy for gastric adenocarcinoma from 1997 2004 at Department Surgery, Yongdong Severance Hospital, Yonsei University College Medicine. Results One hundred sixty‐one...
Purpose:The aim of this study was to investigate the clinicopathologic features and prognosis in patients with computed tomography (CT) findings ascites, a focus on correlation peritoneal carcinomatosis.Methods: This included total 157 who underwent surgery for advanced gastric cancer from 2003 2008 at Department Surgery, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea, which were analyzed retrospectively.Results: Fourteen (8.9%) presented ascites their CT scan.Among them, 10...
PURPOSE: In gastric adenocarcinoma (GC), the major tumor suppressor genes (TSGs) such as p16, PTEN, Rb, E-cadherin, and p53, may play important roles in various regulatory pathways suppression. This study evaluated loss of heterozygosity (LOH) microsatellite protein expression 5 TSGs results were examined for their correlation with clinicopathological factors. METHODS: LOH analysis was carried out using polymerase chain reactions 15 polymorphic markers chromosomes containing 100 surgically...
Appendicitis is a common intra-abdominal inflammatory disease, and morbidity increases with age when perforation occurs. Because, not all patients require emergency surgery, there have been numerous studies on factors for predicting perforated appendicitis. In this study, we aimed to confirm whether the delta neutrophil index (DNI) time from symptom onset surgery are effective predictors appendicitis in different groups.This was retrospective study conducted 542 who underwent at Kangdong...
(Background) The aim of this study was to investigate the prognostic impact lymphatic invasion in gastric cancer, focusing on survival differences between N stage groups. (Methods) A total 398 consecutive patients who underwent curative gastrectomy for primary adenocarcinoma from January 2006 December 2015 were analyzed retrospectively using data a prospectively collected registry database. We compared various clinicopathological features and invasion-positive -negative (Results) Of...
To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and difference efficacy AC administered by surgical medical oncologists patients with stage II or III gastric cancers.We performed a retrospective observational study among 1,049 who underwent curative resection received for cancers between February 2012 December 2013 at 29 tertiary referral university hospitals Korea. minimize influence potential confounders on selection bias, propensity score matching (PSM)...
Background/Aim: This study examined the role of GNAO1 as a potential tumor suppressor gene in colorectal cancer (CRC). Materials and Methods: RNA-seq data analysis revealed significant down-regulation colon tissues compared to normal tissues. Results: over-expression CRC cell lines inhibited proliferation, migration, formation both vitro vivo. suggests that exerts its tumor-suppressive effects by inhibiting mTOR/S6K signaling pathway. The observed correlation between expression progression...
Sepsis is one of the most common causes death after surgery. Several conventional scoring systems have been developed to predict outcome sepsis; however, their predictive power insufficient. The present study applies explainable machine-learning algorithms improve accuracy predicting postoperative mortality in patients with sepsis caused by peritonitis.We performed a retrospective analysis data from demographic, clinical, and laboratory analyses, including delta neutrophil index (DNI), WBC...
복강경 위절제술은 1990년대 초부터 시행되어온 이래 일본과 한국을 중심으로 급속한 발전을 거듭해 왔다. 현재 위절제 술은 림프절 전이가 없거나, 위 주위 1군 림프절에 국한된 있는 조기 위암을 적응증으로 하고 있으나, 없는 고유근층을 침범한 진행성 위암에서도 점차 확대 시행되고 있다. 현재까지 복강경과 개복하 위절제술을 비교한 대부분의 연구 결 과에서 수술 후 장운동 회복, 입원 기간 등의 회복 뿐 아 니라, 장기간의 삶의 질 평가에서도 위절제술이 개복술에 비해 우월한 결과를 보였다. 또한, 중 출혈양이 복강경군에 서 더 적었고, 합병증도 개복군과 차이가 없거나 오히려 적어, 기술적으로 충분히 안전함을 확인할 수 있었다. 개복술과 동등한 수준의 청소술이 가능하였 으며, 생존율 역시 개복술에서와 차이를 보이지 않아, 종 양학적으로도 안전하게 시행 될 있을 것으로 생각되나, 수술의 투관침 전이나 기복이 종양이 미치는 영향에 대한 연구가 부족하므로 추가 필요할 것이다. 암에서...
Treatment of Bone metastasis in Breast Cancer 15 서 론 골전이는 암이 진행 과정 중 최종 단계로서 많은 합병증과 함께 사망률의 증가가 따르게 된다.여러 종류의 암에서 골전이가 원인에 대하여 Stepem Paget(2)은"The seed and soil"가설 을 주장하였다.이것은 어떤 조직(soil)은 암세포(seed)가 생 존하고 성장하는데 알맞은 환경을 제공한다는 가설이다.현재 이 에 대한 분자생물학적인 설명은 혈중의 암세포들이 골수조직과 같이 비옥한 곳에 머물게 되고 미세전이 성장을 시작한다는"The soil"가설을 뒷받침하고 있다.다른 장기에 비해 뼈는 역동적이며 복잡한 구조로서 암세포에 적절한 미세환경을 제공함 으로써 전이의 호발 부위가 있다.암세포가 뼈에서 성장하려 면 혈액이 풍부하게 공급되어야 하는데 적색골수가 축골, 늑 골, 장골의 근위부 골간단, 척추가 이에 해당한다.가장 전이를 잘 하는 장소는 척추, 대퇴골, 골반골,...