A5100639299- Adenosine and Purinergic Signaling
- Cell Adhesion Molecules Research
- Cardiovascular Effects of Exercise
- Fuel Cells and Related Materials
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Organoboron and organosilicon chemistry
- Multiple Myeloma Research and Treatments
- Ginseng Biological Effects and Applications
- Plant Molecular Biology Research
- Polydiacetylene-based materials and applications
- Oral health in cancer treatment
- Endoplasmic Reticulum Stress and Disease
- Vitamin C and Antioxidants Research
- Phytochemical Studies and Bioactivities
- Ginger and Zingiberaceae research
- Cell death mechanisms and regulation
- Folate and B Vitamins Research
- Liver Diseases and Immunity
- Amyotrophic Lateral Sclerosis Research
- Plant Stress Responses and Tolerance
- Atrial Fibrillation Management and Outcomes
- Biochemical Acid Research Studies
Novarex (South Korea)
2018-2020
Pusan National University Hospital
2019
Ewha Womans University
2017
Georgia Regents Medical Center
2016
Gyeongsang National University Hospital
2016
Nihon University
2014-2015
Sungkyunkwan University
2014
Samsung Medical Center
2014
Pohang University of Science and Technology
2013
Korea Basic Science Institute
2012
The rice roots are highly salt-sensitive organ and primary root growth is rapidly suppressed by salt stress. Sucrose nonfermenting 1-related protein kinase2 (SnRK2) family one of the key regulator hyper-osmotic stress signalling in various plant cells. To understand early response identify SnRK2 signaling components, proteome changes transgenic over-expressing OSRK1, a kinase were investigated. Proteomes analyzed two-dimensional electrophoresis spots identified LC-MS/MS from wild type OSRK1...
Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, prevention histamine release and modulation CaCC chloride channel.Objective: We investigated laxative effect action mechanism QCT in Lop-induced constipation model.Materials methods: Constipation SD rats was induced by subcutaneous injection loperamide (Lop) (4 mg/kg weight) 0.5% Tween 20 twice day three days. After 24 h, group...
Nitric oxide (NO) and tumor necrosis factor α (TNF-α) are the major mediators produced in activated macrophages which contribute to circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) isolated from medicinal plant, Saussurea lappa, inhibited production of NO lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric synthase enzyme expression. This also decreased TNF-α level LPS-activated systems vitro vivo. Thus,...
Abstract A liposome‐based fluorescence sensing system for apoptotic cells has been developed from stimuli‐responsive poly(diacetylene)‐liposomes the first time. The combination of liposome components, a phosphatidylserine‐binding Zn II ‐dipicolylamine component and an alcohol‐terminated in ratio 2:1, led to efficient detection cells, as demonstrated by confocal microscopy FACS analysis. shows color change blue reddish purple emits turn‐on mode upon interaction with phosphatidylserine....
// Jin Hyun Kim 1, 2 , Kyung Mi 3 Myeong Hee Jung 1 Hwa 2, 4 Ki Mun Kang 5 Bae Kwon Jeong Pyeong Je Park Seung Hoon Woo Biomedical Research Institute, Gyeongsang National University Hospital, Jinju, Gyeongnam, Republic of Korea Institute Health Science, Department Otolaryngology, Internal Medicine, Radiation Oncology, School Medicine and Correspondence to: Woo, email: lesaby@hanmail.net Keywords: alpha lipoic acid, salivary gland, radiation, Nox-2, complication Received: December 27, 2015...
Abstract Background A novel extract of mulberry leaves fermented with Cordyceps militaris (EMfC) is reported to exert anti-obesity activity, although their molecular mechanism during hepatic steatosis has not verified. Methods To investigate the role inflammation and autophagy anti-hepatic effects EMfC, we measured alterations in key parameters for inflammatory response pathway liver tissues high fat diet (HFD) treated C57BL/6N mice after exposure EMfC 12 weeks. Results Significant effects,...
Gastroesophageal reflux is associated with numerous pathologic conditions of the upper aerodigestive tract. Gastric pepsin within contributes to immunologic reactions in tonsil. In this study, we aimed find relationships between and tonsillar hypertrophy.We explored notion whether hypertrophy was due pepsin-mediated gastric tonsil hypertrophy. Fifty-four children 30 adults tonsillitis were recruited before surgical treatment. Blood tissues from each patient harvested for analysis changes...
We showed previously that microtubule disruptor 2-methoxyestradiol (2ME) induces hyperpermeability of the endothelial monolayer via mechanisms include activation p38 and Rho kinase (ROCK) rearrangement actin cytoskeleton. Using protein C (PKC) inhibitors Ro-31-7549 Ro-32-0432, we show in vitro vivo 2ME-induced barrier dysfunction is also PKC-dependent. The known PKC substrates ezrin, radixin, moesin (ERM) were recently implicated regulation permeability. This study tested hypotheses ERM...
A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis streptozotocin-induced diabetes. To investigate whether a novel extract of fermented with Cordyceps militaris (EMfC) could suppress ER fatty liver, alterations key parameters for response measured high fat diet (HFD)-induced obese C57L/6 mice treated EMfC 12 weeks. The area adipocytes liver section significantly decreased...
Conflicting results for morusin activity during adipogenic differentiation are reported in 3T3-L1 adipocytes and cancer cells. To elucidate the influence of on fat metabolism, their anti-obesity effects molecular mechanism were investigated cells primary adipocytes. Morusin at a dose less than 20 µM does not induce any significant change viability The accumulation intracellular lipid droplets stimulated with 0.5 mM 3-isobutyl-1-methylxanthine, 1 dexamethasone, 10 µg/mL insulin DMEM...
Serum-ferritin levels may be associated with psychiatric symptoms among the elderly; however, this association has not been extensively studied. The aim of study was to evaluate between serumferritin and mental health issues in older Koreans.This cross-sectional included large-scale national data from Korea National Health Nutrition Examination Survey 2010-2012. In total, 1,802 Koreans (≥65 years old) were included. assessed short sleep duration, stress, depressed mood, suicidal ideation....
Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer.However, its oral administration impeded by very low bioavailability (<5%) due to Pglycopprotein (P-gp) efflux pump effect.This study investigated in vitro vivo P-gp inhibitory effects adamantyl derivatives AC-603 AC-786 rats.Two tested this increased cytotoxicity daunomycin (DNM) overexpressed line inhibiting...
Hexakis[ω-(trichlorosilyl)alkyl]benzenes 2 [alkyl = ethyl (a), propyl (b)] containing 18 peripheral chlorine substituents on the six silicon atoms as functionalities were prepared in 72% and 53% yields by one-pot reaction of benzene with a 6-fold excess ω-chloroalkyltrichlorosilanes such 2-chloroethyltrichlorosilane (1a) 3-chloropropyltrichlorosilane (1b) presence aluminum chloride, respectively. Single-crystal X-ray analysis compound 2b reveals that silicons are symmetrically located...
With recent advances in cancer stem cell analysis, it has been postulated that the transformation of hepatic and progenitor cells underlies development certain liver cancers. Human C‑KIT is a transmembrane type III receptor protein with intrinsic tyrosine kinase activity proposed as marker for human embryonic cells. In addition, functions maintaining undifferentiated state cells, identified hematopoietic stem/progenitor The present study an unusual case C‑KIT‑positive tumor phenotype...
489 Background: Dysbiosis of intestinal microbiota is promoting the development colorectal cancer (CRC). We confirmed composition from fecal sample Korean CRC patients. Metagenomic analysis was performed and we isolated single microbes through culture-based method. Methods: samples were collected 12 individuals. Metagenome Sequencing based on 16S rRNA gene amplicon Illumina MiSeq platform. The bacteria strains subcultivated agar plate medium in aerobic anaerobic further identified by using...
Thalidomide is an immunomodulatory drug and primarily prescribed as a sedative hypnotic. Treatment with thalidomide inhibited osteoblast development. Bone sialoprotein (BSP) mineralized tissue-specific protein that appears to function in the initial mineralization of bone. BSPexpression essentially restricted differentiated cells connective tissues expression BSPis developmentally regulated. To determine molecular mechanisms involved suppression bone formation we have analyzed effects on...
Adenosine is an endogenous purine nucleoside. Cellular signaling by adenosine occurs through four known receptor subtypes (A1, A2a, A2b, A3). Extracellular concentrations from normal cells are approximately 300 nM; however, in response to cellular damage, these quickly elevated (600–1,200 nM). Locally concentration can reach ~100 μM. In regard stress or injury, the function of primarily that cytoprotection preventing tissue damage during instances hypoxia, ischemia. Recent data implicate...