A5100415637- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
- Biochemical and Molecular Research
- Phytochemistry and Bioactive Compounds
- Gout, Hyperuricemia, Uric Acid
- Diet and metabolism studies
- Dysphagia Assessment and Management
- Biological and pharmacological studies of plants
- Salivary Gland Disorders and Functions
- Cutaneous Melanoma Detection and Management
- Colorectal and Anal Carcinomas
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic and Hepatic Oncology Research
- Morinda citrifolia extract uses
- Microscopic Colitis
- 3D Printing in Biomedical Research
- Case Reports on Hematomas
- HER2/EGFR in Cancer Research
- Ocular Surface and Contact Lens
- Omental and Epiploic Conditions
Daewoong Pharmaceutical (South Korea)
2023-2024
Pusan National University
2016-2024
Inha University
2021
Hanyang University
2004-2019
Hanyang University Seoul Hospital
2006-2019
Anyang University
2016
Korea University
2015
Korea University Medical Center
2015
Hanyang University Guri Hospital
2006
Context: Quercetin (QCT) has been known as a potential therapeutic strategy for gastrointestinal diseases because it contributes to the stabilization of mast cells, prevention histamine release and modulation CaCC chloride channel.Objective: We investigated laxative effect action mechanism QCT in Lop-induced constipation model.Materials methods: Constipation SD rats was induced by subcutaneous injection loperamide (Lop) (4 mg/kg weight) 0.5% Tween 20 twice day three days. After 24 h, group...
Several natural products containing tannins are used as traditional medicines for treatment of constipation; however, their pharmacological mechanism is not well understood. The laxative effects gallotannin-enriched extract isolated from Galla Rhois (GEGR) were investigated using a constipation model induced by loperamide (Lop) injection. After analysis antioxidant activity GEGR, alterations in the excretion parameters, histological structure, mucin secretion, and related protein levels...
This study evaluated 15 lactic acid bacteria with a focus on their ability to degrade inosine and hypo-xanthine—which are the intermediates in purine metabolism—for management of hyperuricemia gout. After preliminary screening based HPLC, Lactiplantibacillus plantarum CR1 pentosus GZ1 were found have highest nucleoside degrading rates, they therefore selected for further characterization. S . thermophilus IDCC 2201, which possessed hpt gene encoding hypoxanthine-guanine...
Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its constipation yet to be established. Therefore, this study, we investigated the laxative effects Urd on chronic constipation.The phenotypes their related mechanisms were transverse colons SD rats with loperamide (Lop)-induced after treatment 100 mg/kg Urd.The number, weight water contents stools...
Significant phenotypes for constipation were detected in complement 3 (C3) knockout (KO) mice, although no research has been conducted on an association with alteration of gut microbiota. To investigate the effects dysbiosis fecal microbiota from C3 KO mice constipation, composition was characterized mid-colons 16-week-old and their function defecation delay development examined after transplantation (FMT) mice. Some significant alterations phenotypes, including stool parameters...
Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects the action mechanism against this disease. ICR mice were selected produce disease model through oral administration loperamide (Lop), even though SD rats are commonly utilized in studies constipation. To compare responses obtained from three different sources inducers, alterations stool number, histopathological structure, mucin secretion opioid-receptor downstream signaling...
BIOVITA 3 bacterial species (BIOVITA 3), a probiotic blend powder containing Clostridium butyricum IDCC 1301, Weizmannia coagulans 1201, and Bacillus subtilis 1101, has been used as food ingredient for gut health. However, its efficacy in improving constipation not reported. Therefore, we aimed to investigate the functional effects of oral administration well component strains alone (at 1.0 x 109 CFU/day) Sprague-Dawley (SD) rats with loperamide-induced constipation. The study included fecal...
Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the activity gallotannin-enriched extracts isolated from Galla Rhois (GEGR) affects regulation hormones, by examining concentration four and activation their receptors loperamide (Lop)-induced model. Stool parameters, including number, weight water content, were significantly recovered Lop+GEGR treated...
Red Liriope platyphylla (RLP) is a known herbal medicine used in the treatment of some chronic diseases including constipation, neurodegenerative disorders, diabetes and obesity. To determine characterize putative biomarkers that predict laxative effects induced by RLP treatment, alteration endogenous metabolites was measured serum loperamide (Lop)-induced constipation rats after administration extract (EtRLP) using 1H nuclear magnetic resonance (1H NMR) spectral data. The urine volume...
The laxative effects of aqueous extract Liriope platyphylla (AEtLP) on loperamide (Lop)‑induced constipation have been reported; however, the key compounds and mechanism underlying these remain unclear. Therefore, five candidates derived from L. platyphylla: Diosgenin (DG), 5-hydroxymethylfurfural (5-HMF), adenosine (AD), hydroxypropyl cellulose (HPC) uridine (UD) were investigated by examining alteration G protein α (Gα) expression, kinase C (PKC) phosphorylation inositol triphosphate (IP3)...
Complement component 3 (C3) deficiency has recently been reported as one of the novel causes constipation. To identify a unique gene specific to constipation caused by C3 deficiency, total RNA extracted from mid colon knockout (C3 KO) mice was hybridized oligonucleotide microarrays, and function candidate verified in vitro vivo models. KO used for microarrays showed definite phenotypes Overall, compared wild type (WT), 1237 genes were upregulated, 1292 downregulated mice. Of these, major...
Background and Purpose: The anti-obesity effects of vitalmelon extracts have been well verified in only adipogenesis lipogenesis adipocytes high-fat diet-induced obesity mice except lipolysis. Therefore, we were investigated the novel function edible fruit water extract (VW) on Methods: changes free glycerol release, cyclic adenosine monophosphate (cAMP)-dependent signaling pathway, expression β-oxidation-related regulators analyzed 3‐isobutyl‐1‐methylxanthine, dexamethasone, insulin...
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Abstract This study evaluated 15 lactic acid bacteria in terms of their ability to degrade inosine and hypoxanthine—which are the intermediates purine metabolism—for management hyperuricemia gout. After a preliminary screening based on HPLC, CR1 ( Lactiplantibacillus plantarum ) GZ1 pentosus showed highest nucleoside degrading rates were therefore selected for further characterization. IDCC 2201 S. thermophilus ), which possessed hpt gene encoding hypoxanthine-guanine...