A5024491216- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal motility and disorders
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Dysphagia Assessment and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Esophageal Cancer Research and Treatment
- Congenital gastrointestinal and neural anomalies
- Diet and metabolism studies
- Intestinal and Peritoneal Adhesions
- Pancreatitis Pathology and Treatment
- Veterinary medicine and infectious diseases
- Microscopic Colitis
- Gut microbiota and health
- Medical Device Sterilization and Disinfection
- Colorectal Cancer Surgical Treatments
Catholic University of Daegu
2016-2025
University of Nevada, Reno
2008-2025
Daegu Catholic University Medical Center
2015-2022
Korea Institute of Ceramic Engineering and Technology
2016
Kyungpook National University
2001-2016
Keimyung University
2016
Youngsan University
2016
Catholic University of America
2014
Summary Background Tegoprazan is a novel potassium‐competitive acid blocker that has fast onset of action and can control gastric pH for prolonged period, which could offer clinical benefit in acid‐related disorders. Aim To confirm the non‐inferiority tegoprazan to esomeprazole patients with erosive oesophagitis (EE). Methods In this multicentre, randomised, double‐blind, parallel‐group comparison study, 302 Korean endoscopically confirmed EE (Los Angeles Classification Grades A‐D) were...
Tegoprazan is a novel, fast- and long-acting potassium-competitive acid blocker that suppresses gastric secretion, which could benefit patients with non-erosive reflux disease (NERD), type of gastroesophageal disease.To evaluate the efficacy safety profiles tegoprazan compared those placebo in Korean NERD.In this phase 3, double-blind, placebo-controlled, multicentre study, 324 NERD were randomised into three treatment groups: 50 mg, 100 mg placebo. These drugs provided once daily for 4...
Fexuprazan, a novel potassium-competitive acid blocker, reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells. Fexuprazan's suppression of was maintained healthy individuals for 24 h dose-dependent manner.To compare fexuprazan to esomeprazole and establish its efficacy safety patients with erosive esophagitis (EE).Korean adult endoscopically confirmed EE were randomized 1:1 receive 40 mg or once daily eight weeks. The primary endpoint proportion healed...
Aliment Pharmacol Ther 2012; 35: 56–65 Summary Background The eradication rates following standard triple therapy for Helicobacter pylori infection are declining worldwide. Recent studies have shown that sequential H. yields high cure rates. Aim To compare the efficacy and tolerability of a regimen as first‐line treatment with regimen. Methods A total 348 naïve ‐infected patients from six hospitals in Korea were assigned randomly to or groups. Standard consisted 20 mg rabeprazole, 1 g...
Using data from the real world to solve clinical questions that cannot be answered using trials is attracting more attention. Clinical outcomes for patients with esophageal cancer in a real-world setting might different randomized controlled trials. This study aimed provide on treatment and prognosis Korean cancer. retrospective cohort included newly diagnosed cases of at 19 tertiary hospitals between January 1, 2005 December 31, 2017. Cancer staging was defined according 7th edition...
Prokinetic agents and neuromodulators are among the treatment options for functional dyspepsia (FD), but their comparative efficacy is unclear. We aimed to compare of mosapride controlled-release (CR) nortriptyline in patients with FD after 4 weeks treatment.
Between endoscopic sphincterotomy (ES) alone and combined large balloon dilation (ES-LBD) groups, efficacy long-term complications, difference in biliary stone recurrence rate, risk factors of were compared.Medical records 222 patients who underwent ERCP for removal retrospectively reviewed. Patients with dilated CBD ≥11 mm follow-up longer than 6 months included.There 101 ES-LBD group 121 ES group. Mean duration was 25.0 (6-48) 13.0 (6-43) months, respectively (p=0.001). There no number...
Advances in endoscopic submucosal dissection (ESD) techniques have led to the development of expanded criteria for resection early gas-tric cancer (EGC). The aim this study was evaluate short- and long-term outcomes ESD using indication cri-teria.A total 1,105 patients underwent EGC at six medical centers. were classified into following two groups based on lesion size, presence ulceration pathological review an absolute group (n=517) (n=588).The curative rates (91.1% vs 91.3%, p=0.896)...
Abstract Background Probiotics can be beneficial in irritable bowel syndrome ( IBS ). Mosapride citrate, a selective 5‐ HT 4 receptor agonist, stimulates gastrointestinal motility. We investigated the efficacy of combination therapy with probiotics and mosapride for non‐diarrheal‐type . Methods Two hundred eighty‐five patients were randomly assigned to either Bacillus subtilis Streptococcus faecium ) at one four different doses or placebo weeks. The primary outcome was proportion...
Various foods trigger and/or worsen the symptoms of irritable bowel syndrome (IBS). However, Korean food-related gastrointestinal (GI) in IBS patients have not yet been investigated. This study aims to evaluate prevalence self-reported food intolerance and determine items groups perceived by their GI symptoms.We recruited 393 subjects, comprising 101 patients, 167 symptomatic non-IBS 125 control subjects. All participants completed a questionnaire identify most problematic assess occurrence...
Hyun Lim, Ju Yup Lee, Yong Hwan Kwon, Hee Seok Moon, Jong Kyu Park, Ki Bae Kim, Sang Wook Young Hoon Youn, Gyun Gwang Ha Ji Won Jae-Young Jang, Kye Sook Joong Goo Hyun-Soo Su Jin Hong, Kwang Jae Suck Chei Choi, Jeong Seop Nayoung Jong-Jae Yirang Sung Hwoon-Yong Jung. Gut and Liver -0001;0:. https://doi.org/10.5009/gnl240390
Prostaglandin E2 (PGE2) actions on intestinal motility are complex due the differential expression of PGE2 receptors EP1-EP4. We sought to determine electrical pacemaker and contractile activity circular longitudinal muscle layers murine small intestine. Intracellular microelectrode isometric force measurements were performed examine effects receptor activation layers. In two produced responses. layer caused dose-dependent membrane hyperpolarization reduction in slow wave amplitude,...
Interstitial cells of Cajal (ICC) are distributed through the gastrointestinal (GI) tract, but functional role these comes primarily from studies mice. Whether functions ICC similar in larger animals is largely speculative. We investigated whether Kit mutation Ws/Ws rats had consequences on populations stomach, small intestine, and colon loss resulted defects to mutations Immunohistochemical labeling with c-KIT or ANO1 antibodies revealed intramuscular (ICC-IM) reduced myenteric (ICC-MY)...
This study aimed to validate the equivalence of first-line concomitant and hybrid regimens for Helicobacter pylori infection in an era increasing antibiotic resistance. The also assess regimen compliance.H. pylori-infected patients from six hospitals Korea were randomly assigned either or regimens. consisted 20 mg esomeprazole, 1 g amoxicillin, 500 clarithromycin, metronidazole, twice daily 10 days. a 5-day dual therapy (20 esomeprazole daily) followed by quadruple daily).Eradication rates...
AIMTo investigate histologic abnormalities in the gastric smooth muscle of patients with diabetes mellitus (DM). METHODSFull-thickness specimens were obtained from undergoing surgery for cancer.H&E stain and Masson's Trichrome performed
Dysfunction of the gastrointestinal tract occurs in about 76% patients who are diabetic for more than 10 years. Although diabetes-related dysfunctions stomach such as gastroparesis have been extensively studied over recent years, studies mechanism underlying colonic symptoms long-term diabetes models rare. Therefore, goal our study was to clarify nature dysfunction a rat model.The characteristics smooth muscle were investigated Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model...