A5100373022- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 Impact on Reproduction
- DNA and Nucleic Acid Chemistry
- Biological and pharmacological studies of plants
- Pediatric health and respiratory diseases
- Advanced biosensing and bioanalysis techniques
- Allergic Rhinitis and Sensitization
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Osteoarthritis Treatment and Mechanisms
- Seed Germination and Physiology
- Sesame and Sesamin Research
- Circular RNAs in diseases
- Plant-based Medicinal Research
- Glaucoma and retinal disorders
- NF-κB Signaling Pathways
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
- thermodynamics and calorimetric analyses
National Institute of Metrology
2023
Zhejiang Chinese Medical University
2013-2023
Weatherford College
2023
Sichuan University
2021-2022
West China Hospital of Sichuan University
2022
The First Hospital of Kunming
2022
Zhejiang Provincial Hospital of TCM
2020
Soochow University
2020
Wuxi Ninth People's Hospital
2020
Wuzhou University
2020
Oxidative damage plays a critical role in many diseases of the central nervous system. This study was conducted to determine molecular mechanisms involved putative anti-oxidative effects curcumin against experimental stroke. Oxygen and glucose deprivation/reoxygenation (OGD/R) used mimic ischemic insult primary cultured cortical neurons. A rapid increase intracellular expression NAD(P)H: quinone oxidoreductase1 (NQO1) induced by OGD counteracted post-treatment, which paralleled attenuated...
Cytokine immunotherapy represents an attractive strategy to stimulate robust immune responses for renal injury repair in ischemic acute kidney (AKI). However, its clinical application is hindered by nonspecificity kidney, short circulation half-life, and severe side effects. An ideal cytokine AKI requires preferential delivery of cytokines with accurate dosage the sustained-release responses. Herein, we developed a DNA nanoraft precisely arranging interleukin-33 (IL-33) nanoarray on...
Zinc oxide nanoparticles (ZnO NPs) are used widely in consumer and industrial products, however, their influence on gut microbiota metabolism mutual interactions not fully understood. In this study, the effects of ZnO NPs ileal bacterial communities, plasma metabolites, correlations between them were investigated. Hens fed with different concentrations [based Zn; 0 mg/kg (control), 25 mg/kg, 50 100 mg/kg] for 9 weeks. Subsequently, digesta blood collected analysis microflora respectively....
Asthma is a complex inflammatory disorder that plagues large number of people. Schisandrin B an active ingredient the traditional Chinese herbal medicine Schisandra with various proven physiological activities such as anti-inflammatory and antioxidant activities. In this study, we explored effects provided mechanistic insights into activity schisandrin in mouse model ovalbumin- (OVA-) induced allergic asthma. Male BALB/c mice were sensitized challenged OVA to induce asthma treated doses (15...
Background: Although earlier menarche age has been associated with ischemic heart disease in previous observational studies, the relationship's causation not shown. Through two-sample Mendelian randomization (MR), we were able to define causal connection. Methods: We performed Randomization (MR) analysis explore associations between genetically predicted AAM and IHD. Summary-level databases for exposure outcome selected from MR-Base database (https://gwas.mrcieu.ac.uk/). Single-nucleotide...
Guizhi Jia Shaoyao decoction (GSD) is widely used in the clinical treatment of knee osteoarthritis (KOA). However, underlying molecular mechanisms remain unclear. The aim this study was to explore functional GSD treating KOA by utilizing network pharmacology-based approaches.Candidate components and targets were retrieved from Traditional Chinese Medicine Systems Pharmacology database. NCBI, Genecards, Drugbank, Therapeutic Target Database (TTD) establish a target database for KOA. Then, an...
Respiratory syncytial virus (RSV) infection can deteriorate asthma by inducing persistent airway inflammation. Increasing evidence elucidated that pyroptosis plays a pivotal role in asthma. Conciliatory anti-allergic decoction (CAD) exhibits an anti-inflammatory effect ovalbumin (OVA)-induced asthma; however, the effects and mechanisms of CAD RSV-infected asthmatic mice have not yet been elucidated. The model lipopolysaccharide (LPS)-induced 16HBE cell were established, respectively....
Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure established by spectroscopic analysis, including NMR and HR-MS (High Resolution Mass Spectrometry). X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons. Chemical methylation carried out to deduce linkages of O-bridges. The absolute configuration determined calculating ECD (Electronic Circular Dichroism) using TDDFT (Time-Dependent Density...
Danhong injection (DHI) is a traditional Chinese medicine that promotes blood circulation and removes stasis has been widely used in the treatment of stroke. Many studies have focused on mechanism DHI acute ischemic stroke (IS); however, few thoroughly explored its role during recovery. In this study, we aimed to determine effect long-term neurological function recovery after cerebral ischemia related mechanisms. Middle artery occlusion (MCAO) was establish an IS model rats. The efficacy...
Cardio-cerebrovascular disease (CCVD) is a major comorbidity of Coronavirus 2019 (COVID-19). However, the clinical characteristics and outcomes remain unclear. In this study, 102 cases COVID-19 from January 22, 2020 to March 26, in Xixi Hospital Hangzhou were included. Twenty had pre-existing CCVD. Results showed that compared with non-CCVD patients, those CCVD are more likely develop severe (15% versus 1%), proportion pneumonia severity index grade IV was significantly higher (25% 3.6%)....
Abstract The purpose was to induce and treat hemp seeds callus, compare the methods increase germination rate of seed, obtain suitable disinfectant for different hormone ratios promote callus growth. GA 3 , 6-BA, IAA were used seed germination, effects hormones concentrations on studied. Tissue culture select time; induced by using aseptic seedling leaves. with a concentration 20-80mg/L 20-40mg/L can seeds; best disinfection method is: 70% ethanol 1min + 10% NaClO 18min; most combinations...
Using network pharmacology, molecular docking, and microRNA recognition, we have elucidated the mechanisms underlying treatment of asthma by Jinxin oral liquid (JXOL). We began identifying normalizing active compounds in JXOL through searches traditional Chinese medicine systems pharmacology database, SwissADME encyclopedia HERB PubChem. Subsequently, gathered standardized targets these from sources including similarity ensemble approach dataset, UniProt, other databases. Disease were...
The physiological mechanisms which underlie amblyopia are predicted using animal models assess the impact of amblyogenic factors on visual function. This study used monocular-deprived mice as an amblyopic model to function by flash evoked potentials (fVEP), behavioral assessment, and plasticity.A total 294 C57BL/6J (both genders) were in this study. divided into normal control (NC) group monocular deprivation (MD) group. After anesthetized with pentobarbital, fVEP was recorded. Long-term...
Abstract The mechanisms of cytosine and 5‐methylcytosine hydrolytic deamination reactions in the gas phase have been investigated. rate‐determining steps are found by density functional theory (DFT). lower barriers hydrogen hydroxyl radical‐mediated make C‐5 site hot spot for spontaneous mutations. radical inhibits reactions, while clearly leads to an increased risk genetic mutagenesis. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem,
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