A5100616496- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Biofuel production and bioconversion
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Enzyme Catalysis and Immobilization
- NF-κB Signaling Pathways
- Ginseng Biological Effects and Applications
- Memory and Neural Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- Beetle Biology and Toxicology Studies
- Plant tissue culture and regeneration
- Crystallography and molecular interactions
- Insect Resistance and Genetics
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- RNA modifications and cancer
- Extracellular vesicles in disease
- Inflammasome and immune disorders
Tibet Academy of Agricultural and Animal Husbandry Sciences
2024-2025
Affiliated Hospital of Jining Medical University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northwest A&F University
2023-2024
Tianjin Medical University General Hospital
2019-2024
Tianjin Medical University
2018-2024
First Affiliated Hospital of Henan University
2024
University of Science and Technology of China
2024
South China University of Technology
2024
Xiangnan University
2024
Salinity is a major abiotic stress factor that seriously affects plant growth. Many genes are involved in the response to salt with various metabolism pathways. A number of transcription family have been found be response, and NAM, ATAF CUC (NAC) factors thought act as active regulators during stress, especially stress. In this study, we detected rice NAC coding gene, OsNAC041, confirmed it influenced germination seeds under tolerance plants. OsNAC041 was primarily expressed leaves located...
Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel therapeutic tool for preventing human diseases. However, the number of well-verified plant ELNs remains limited. In this study, microRNAs in derived from fresh Rehmanniae Radix, well-known traditional Chinese herb treating inflammatory and metabolic diseases, were determined by using microRNA sequencing to investigate active components protection against lipopolysaccharide (LPS)-induced acute lung inflammation vivo...
Abstract Background Bone or brain metastases may develop in 20–40% of individuals with late‐stage non‐small‐cell lung cancer (NSCLC), resulting a median overall survival only 4–6 months. However, the primary tissue's distinctions between bone, and intrapulmonary NSCLC at single‐cell level have not been underexplored. Methods We conducted comprehensive analysis 14 tissue biopsy samples obtained from treatment‐naïve advanced patients bone ( n = 4), 6) 4) metastasis using sequencing originating...
Studies on maize evolution and domestication are largely limited to the nuclear genomes, contribution of cytoplasmic genomes selection modern remains elusive. Maize have been classified into fertile (NA NB) cytoplasmic-nuclear male-sterility (CMS-S, CMS-C, CMS-T) groups, but their contributions breeding not systematically investigated.
Understanding the genetic makeup of local sheep breeds is essential for their scientific conservation and sustainable utilization. The Liangshan semi-fine-wool (LSS), a Chinese breed renowned its soft wool, was analyzed using whole-genome sequencing data including 35 LSS, 84 from other domestic breeds, 20 Asiatic mouflons. We investigated composition LSS by conducting analyses population structure, runs homozygosity, genomic inbreeding coefficients, selection signature. Our findings...
Heat shock proteins (Hsps) are common molecular chaperones present in all plants that accumulate response to abiotic stress. Small heat (sHsps) play important roles alleviating diverse stresses, especially However, very little is known about the MsHsp20 gene family wild apple Malus sieversii, a precious germplasm resource with excellent resistance characteristics. In this study, 12 putative M. sieversii Hsp20 genes were identified from RNA-Seq data and analyzed terms of structure...
Posttraumatic stress disorder (PTSD) is an anxiety characterized by intrusive recollections of a severe traumatic event and hyperarousal following exposure to the event. Human animal studies have shown that change amygdala activity after may contribute occurrences some symptoms or behaviors patients animals with PTSD. However, it still unknown how neuronal activation different sub-regions in changes during development In present study, we used single prolonged (SPS) procedure obtain model...
Abstract Low‐coverage whole genome sequencing (lcWGS) has great potential to effectively genotype large‐scale population and provide solid data for imputation; however, the time imputation needs be optimized. There is also no publicly available reference panel selection in cattle. Here, we proposed a combination of Beagle v5.4 phasing GLIMPSE2 imputation, which fast accurate cattle lcWGS data. Furthermore, established multi‐breed with 61.8 million SNPs based on 2976 worldwide cattle, 1766...
Our previous study has reported that mitogen-activated protein kinase 4 (MAP4K4) regulates the growth and survival of hepatocellular carcinoma (HCC) cells. This was undertaken to explore roles MAP4K4 in epithelial-mesenchymal transition (EMT) metastasis HCC. Effects overexpression knockdown on migration, invasion, EMT HCC cells were examined. The vivo role lung determined nude mice. relationship between expression human specimens by immunohistochemistry. significantly enhanced migration...
Acute traumatic event exposure is a direct cause of post-traumatic stress disorder (PTSD). Amygdala suggested to be associated with the development PTSD. In our previous findings, different activation patterns GABAergic neurons and glutamatergic in early or late stages after were found. However, neural plastic mechanism underlying role basolateral amygdala (BLA) remains unclear. Therefore, this study mainly aimed at investigating time-dependent morphologic electrophysiological changes BLA...
Abstract Background Pathological studies have shown an association between psoriasis and renal podocyte injury, the specific mechanism of injury in remains unclear, with no effective treatments currently available. This study aimed to investigate underlying mechanisms epidermal cell evaluate therapeutic effect Cosentyx. Materials methods A psoriasis‐like mouse model was established using BALB/C mice, Cosentyx treatment administered via intraperitoneal injection. Various parameters, including...