A5022308259- RNA modifications and cancer
- Cancer-related gene regulation
- HVDC Systems and Fault Protection
- Probiotics and Fermented Foods
- Cancer-related molecular mechanisms research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced biosensing and bioanalysis techniques
- Inflammasome and immune disorders
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Quinazolinone synthesis and applications
- Advanced Breast Cancer Therapies
- Ubiquitin and proteasome pathways
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Microwave-Assisted Synthesis and Applications
- Luminescence and Fluorescent Materials
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
Hangzhou Medical College
2021-2024
Chinese Academy of Sciences
2022-2024
Zhejiang Academy of Medical Sciences
2022-2023
Zhejiang Cancer Hospital
2022-2023
University of Chinese Academy of Sciences
2022-2023
Southern Medical University
2018-2021
Plant-derived exosome-like nanoparticles (ELNs) have been proposed as a novel therapeutic tool for preventing human diseases. However, the number of well-verified plant ELNs remains limited. In this study, microRNAs in derived from fresh Rehmanniae Radix, well-known traditional Chinese herb treating inflammatory and metabolic diseases, were determined by using microRNA sequencing to investigate active components protection against lipopolysaccharide (LPS)-induced acute lung inflammation vivo...
Abstract Kinase inhibitors against Cyclin Dependent 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response lung forming a feedback loop with CDK6. LRPPRC binds to CDK6 -mRNA, increasing the stability expression of its downstream E2F Transcription Factor 1 (E2F1), bind promoter elevate...
In order to improve the fluorescence quantum yield (QY) of NIR-II-emitting nanoparticles, D-A-D fluorophores are typically linked intramolecular rotatable units reduce aggregation-induced quenching. However, incorporating such often leads a twisted molecular backbone, which affects coupling within unit and, as result, lowers absorption. Here, we overcome this limitation by cross-linking NIR-II form 2D polymer network, simultaneously achieves high QY well-controlled fluorophore separation and...
A versatile and practical “on-water” protocol was newly developed to synthesize quinazolinones using o-bromobenzonitrile as a novel starting material. Studies have found that air well water plays an important role in synthesis of quinazolinones. Further investigation indicated dihydroquinazolinones can be prepared with this under the protection N2. The extended other substrates various were obtained. o-Bromobenzamide, o-aminobenzonitrile, o-aminobenzamide also evaluated materials, results...
Long noncoding RNAs (lncRNAs) have been reported to participate in regulating many biological processes, including immune response influenza A virus (IAV). However, the association between lncRNA expression profiles and infection susceptibility has not well elucidated. Here, we analyzed of lncRNAs, miRNAs, mRNAs among IAV-infected adult rat (IAR), normal (AR), junior (IJR), (JR) by RNA sequencing. Compared with differently expressed lncRNAs (DElncRNAs) AR IAR, 24 specific DElncRNAs were...
To characterize the bacterial strain LGV03 isolated from reproductive tract of healthy women and evaluate its safety.The strains were purified using MRS agar by dilution plating streak plate method. Gram staining was used to observe morphology identify Gram-negative -positive strains. The physiological biochemical properties bacteria assessed VITEK ANC card. Strain identified molecular biology phylogenetic analysis tested for hemolysis on blood plates. E-test method performed examine...