A5005160921- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Reproductive tract infections research
- Phytochemical compounds biological activities
- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Advanced Breast Cancer Therapies
- Extracellular vesicles in disease
- Gut microbiota and health
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Peptidase Inhibition and Analysis
- Synthetic Organic Chemistry Methods
- Advanced biosensing and bioanalysis techniques
- Protein Degradation and Inhibitors
Chinese Academy of Sciences
2021-2025
University of Chinese Academy of Sciences
2023-2024
Zhejiang Cancer Hospital
2023-2024
University of Science and Technology of China
2023-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2023
Shanghai Institute of Materia Medica
2021
Targeted protein degradation (TPD) is an emerging technique for regulation. Currently, all TPD developed in eukaryotic cells relies on either ubiquitin-proteasome or lysosomal systems, thus are powerless against target proteins membrane organelles lacking proteasomes and lysosomes, such as mitochondria. Here, we a mitochondrial protease targeting chimera (MtPTAC) to address this issue. MtPTAC bifunctional small molecule that can bind caseinolytic P (ClpP) at one end the other....
Abstract Kinase inhibitors against Cyclin Dependent 4 and 6 (CDK4/6i) are promising cancer therapeutic drugs. However, their effects limited by primary or acquired resistance in virtually all tumor types. Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response lung forming a feedback loop with CDK6. LRPPRC binds to CDK6 -mRNA, increasing the stability expression of its downstream E2F Transcription Factor 1 (E2F1), bind promoter elevate...
Triple-negative breast cancer (TNBC) is a highly malignant tumor that requires effective therapeutic targets and drugs. Oxidative phosphorylation (OXPHOS) metabolic vulnerability of TNBC, but the molecular mechanism responsible for enhanced OXPHOS remains unclear. The current strategies target electronic transfer function cannot distinguish cells from normal cells. Investigating underlying regulation developing corresponding therapy TNBC great significance. Immunohistochemistry sequencing...
Abstract Extracellular vesicles (EVs) have emerged as promising biomaterials for the treatment of different disease. However, only handful types EVs with clinical transformation potential been reported to date, and their preparation on a large scale under biosafety‐controlled conditions is limited. In this study, we characterize novel type EV application potential: dehydration‐induced extracellular (DIMVs). DIMV micron‐diameter cell vesicle that contains more bioactive molecules, such...
In order to improve the fluorescence quantum yield (QY) of NIR-II-emitting nanoparticles, D-A-D fluorophores are typically linked intramolecular rotatable units reduce aggregation-induced quenching. However, incorporating such often leads a twisted molecular backbone, which affects coupling within unit and, as result, lowers absorption. Here, we overcome this limitation by cross-linking NIR-II form 2D polymer network, simultaneously achieves high QY well-controlled fluorophore separation and...
Abstract Ovarian cancers, especially high‐grade serous ovarian cancer (HGSOC), are one of the most lethal age‐independent gynecologic malignancies. Although pathogenic microorganisms have been demonstrated to participate in pathogenesis multiple types tumors, their potential roles development remain unclear. To gain an insight into microbiome‐associated and identify diagnostic biomarkers, we applied different techniques analyse microbiome serum metabolome resources. We found that vaginal...
Abstract Bacterial conjugation, a commonly used method to horizontally transfer functional genes from donor recipient strains, plays an important role in the genetic manipulation of bacteria for basic research and industrial production. Successful conjugation depends on donor‐recipient cell recognition tight mating junction formation. However, efficiency conjugative is usually very low. In this work, we developed new technique that employed DNA molecule “glue” increase match frequency...