A5029243508- Immune Response and Inflammation
- Extracellular vesicles in disease
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Analytical Chemistry and Chromatography
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Inflammatory mediators and NSAID effects
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Bioactive Compounds and Antitumor Agents
- Respiratory Support and Mechanisms
- Drug Transport and Resistance Mechanisms
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Virus-based gene therapy research
- RNA modifications and cancer
- Plant-based Medicinal Research
- interferon and immune responses
- Ferroptosis and cancer prognosis
- Bioactive Natural Diterpenoids Research
- Cancer, Hypoxia, and Metabolism
Hangzhou Medical College
2020-2024
Yangzhou University
2024
Zhejiang Academy of Medical Sciences
2009-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
National Taiwan University
2010-2011
Background: Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, is potential candidate for cancer chemotherapy. However, Tet has poor aqueous solubility and short half-life, which limits its bioavailability efficacy. Liposomes have been widely utilized to enhance the efficacy of drugs. Methods: In this study, Tet-loaded stealth liposomes (S-LPs@Tet) were prepared by ethanol injection method. Furthermore, physicochemical characterisation, biopharmaceutical behaviour, therapeutic efficacy,...
Naringin is one of the natural flavonoids extracted from many Chinese medicines. It ameliorates endothelial dysfunctions in atherosclerosis, diabetes, and cardiovascular diseases through free radical scavenging antioxidant activities. The aim present study was to investigate protective effects naringin against pulmonary permeability addition airway inflammation lipopolysaccharide/cigarette smoke (LPS/CS)-induced chronic obstructive disease (COPD) mice.The COPD mice were exposed LPS twice...
The enantio-separations of eight 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (2-APA NSAIDs) were established using reversed-phase high-performance liquid chromatography with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) as chiral mobile phase additive for studying the stereoselective skin permeation suprofen, ketoprofen, naproxen, indoprofen, fenoprofen, furbiprofen, ibuprofen and carprofen. effects composition, concentration HP-beta-CD column temperature on retention...
Purpose: Abnormal glycolysis of immune cells contributed to the development inflammatory response. Inhibition this Warburg phenotype could be a promising strategy for preventing various diseases. Iridin (IRD) is natural isoflavone, and exerts anticancer, antioxidant, anti-inflammatory effects. However, underlying mechanism IRD on acute inflammation remains unknown. In study, protective effects against lipopolysaccharide (LPS)-induced were investigated in murine macrophage RAW264.7 mice....
Codonopsis lanceolata is a perennial smelly herbaceous plant and widely employed for the treatment of various lung cancer inflammation. However, anticancer substances in C. their underlying mechanisms had not been well clarified. In this study, six compounds were obtained from water extracts polyacetylenes (CLP) then identified as syringin, codonopilodiynoside A, lobetyol, isolariciresinol, lobetyolin, atractylenolide III. Treatment with CLP remarkably suppressed cell proliferation, colony...
Genistein (Gen), a natural polyphenolic compound, has emerged as promising candidate for lung cancer treatment. However, the potential clinical application of Gen is limited due to its poor solubility, low bioavailability, and toxic side effects. To address these challenges, biomimetic delivery platform with cell membranes derived from cells carrier material was constructed. This innovative approach aims facilitate targeted drug solve problem biocompatibility synthetic materials.
Plant-derived exogenous microRNAs (miRNAs) regulate human physiological functions by blocking the translation of target mRNAs. Although several computational approaches have been developed to elucidate interactions cross-species miRNAs and their targets in mammals, number verified plant is still limited, biological roles most remain unknown.A miRNA mimic library-based phenotypic screening, which contained 8394 mature published official database miRbase, was performed identify more novel...
Platelets are multifunctional effectors of inflammatory responses and inseparable from the occurrence development various diseases. The platelet membrane (PM) is integrated onto surface a nano-drug delivery system to form PM-cloaked nanoparticles (PM@NPs), which can increase biocompatibility mitigate adverse drug reactions. Owing strong affinity immune regulation adhesion-related antigens on PM focal sites diseases, endows PM@NPs with potential actively target lesions improve therapeutic...
Objective: To prepare everolimus nanoformulations and increase their solubility to suit application in the eye. Methods: The micelles was prepared by thin film dispersion method using Tween-80 (P80) polyoxyethylene stearate (P40S) as carriers. In addition, nanosuspension injection poloxamer 407 (P407), hydroxypropyl methylcellulose (HPMC) polyvinyl alcohol (PVA) stabilizers. It characterized terms of particle size, PDI encapsulation efficiency or drug loading. vitro release rabbit scleral...
<i>Prunella vulgaris</i> has been widely used in the folk medicine of Northeastern Asian countries for treatment acute liver injury and infectious hepatitis. In present study, protective effect aqueous extract from <i>P. was investigated on carbon tetrachloride-induced hepatic fibrosis <i>in vivo</i>. Our data showed that administration at doses 50, 100, 200 mg/kg significantly reduced elevated serum levels alanine aminotransferase, aspartate type III precollagen, hyaluronic acid rats with...
The enantioselectivities of eight 2-arylpropionic acid nonsteroidal anti-inflammatory drugs (2-APA NSAIDs) and two β-blockers on an amylose-tris(3,5-dimethylphenylcarbamate)-based Chiralpak AD-RH (150 × 4.6 mm, 5 μm) column were studied in reverse phase (RP) elution mode. influencing factors such as mobile composition, organic modifiers, temperature investigated. For most the selected NSAIDs, baseline enantioseparation was achieved using a composition acetonitrile–0.05% trifluoroacetic...
Aurantiamide acetate (AA) is a dipeptide derivative with complex pharmacological activities and remarkable effects on preventing treating various diseases. In the current study, we aimed to investigate whether AA can exert protective in mouse model of ALI induced by LPS.In this model, mice were given intranasal LPS for 3 days prior receiving (2.5, 5, 10 mg/kg) via oral gavage. An assessment histopathological changes was performed hematoxylin eosin (HE). Proinflammatory cytokines detected...