Esketamine, a newly developed antidepressant, is the subject of this research which seeks to explore its impact on depressive symptoms in neuropathic pain mice and potential molecular mechanisms involved. Through transcriptome sequencing bioinformatics analysis combined with vivo studies, it was identified that esketamine markedly boosts levels m6A methyltransferase METTL3 AMPA receptor GluA1 subunit. Esketamine activates METTL3, allowing bind mRNA, promoting modification, thereby enhancing...

Testosterone deficiency, as a potential risk factor for aging and aging-related neurodegenerative disorders, might induce mitochondrial dysfunction facilitate the declines of nigrostriatal dopaminergic system by exacerbating defects increasing oxidative damage. Thus, how testosterone levels influence function in substantia nigra was investigated study. The present studies showed that deficiency impaired induced damage to well deficits system. Of four respiratory chain complexes, castration...

In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of hyporesponsiveness ANP are complex, but one potential mechanism decreased expression receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent diuresis natriuresis patients with precise unclear. present study, we found dexamethasone (Dex) dramatically increased NPR-A IMCD cells...

Alzheimer's disease (AD) is a common chronic progressive neurodegenerative disorder, and curative treatment has not been developed. The objective of this study was to investigate the potential effects hydralazine (Hyd, hypertension drug) on development process AD its mechanisms. We treated 6-month-old male APP/PS1 mice with Hyd for 5 weeks, measured changes in behavior pathological status, analyzed differences gene expression by RNA sequencing. results demonstrated that improved cognitive...

Atrial natriuretic peptide (ANP) provides a potent defense mechanism against volume overload in mammals. Its primary receptor, receptor-A (NPR-A), is localized mostly the kidney, but also found hypothalamic areas involved body fluid regulation. Acute glucocorticoid administration produces diuresis and natriuresis, possibly by acting renal system. However, chronic attenuates water sodium excretion. The precise underlying this paradoxical phenomenon unclear. We assume that may activate system...

Abstract Androgen plays a pivotal role in the progression of renal fibrosis. However, whether exogenous androgen treatment to aged male rats can improve age-related fibrosis was not explored. In our study, changes morphological structure, fibrosis, ultrastructure and function, expressions extracellular matrix (ECM), metalloproteinases (MMPs) its tissue inhibitors (TIMPs), tumor growth factor β1 (TGF-β1)/Smad signaling oxidative stress parameters as well nuclear erythroid 2-related...

Background Recent studies show testosterone (T) deficiency worsens cognitive impairment in Alzheimer’s disease (AD) patients. Mitochondrial dysfunction, as an early event of AD, is becoming critical hallmark AD pathogenesis. However, currently, whether T exacerbates mitochondrial dysfunction men with remains unclear. Objective The purpose this study to explore the effects on male mouse models and its potential mechanisms. Methods animal model was performed by castration 3-month-old APP/PS1...

Currently, there are no effective therapeutic agents available to treat Alzheimer's disease (AD). However, edaravone dexborneol (EDB), a novel composite agent used acute ischemic stroke, has recently been shown exert efficacious neuroprotective effects. whether EDB can ameliorate cognitive deficits in AD currently remains unclear. To this end, we explored the effects of on and its potential mechanisms using an animal model (male APP/PS1 mice) treated with for 10 weeks starting at 6 months...

Brain mitochondrial dysfunction and reduced testosterone levels are common features of aging in men. Although evidence suggests that the two phenomena interrelated, it is unclear whether supplementation ameliorates male brain. Here, we show significantly alleviates exploratory behavioral deficits oxidative damage substantia nigra hippocampus rats. These effects were consistent with improved function, reflected by testosterone-induced increases membrane potential (MMP), antioxidant enzyme...

Abstract The present study aimed to evaluate the protective efficacy of testosterone propionate (TP) on age-related liver changes via activation nuclear factor erythroid 2-related 2-antioxidant response element (Nrf2-ARE) pathway in aged rats. Aged rats received subcutaneous injections TP (2 mg/kg/d, 84 days). Oxidative stress parameters and expression levels signal transducer activator transcription 5b (STAT5b), Kelch-like ECH associating protein-1 (Keap1), Nrf2, haem oxygenase-1 (HO-1)...

There is a controversy over the effects of testosterone supplements on dopaminergic function. Both neuroprotective and toxic are reported. The status oxidative stress seems to explain or properties testosterone. To determine efficacy in different stress, present studies analyzed dopamine (DA)-related behaviors neurochemical indices, as well markers nigrostriatal (NSDA) system reserpine-treated aged male rats followed by propionate (TP) supplements. experimental animals was evaluated...

Deficits in coordinated motor behavior and mitochondrial complex V activity have been observed aged males.Testosterone supplementation can improve males.We investigated the effects of testosterone on function substantia nigra (a brain region that regulates activity) male rats.These rats exhibited diminished ATP levels, attenuated activity, reduced expression 3 17 subunits (ATP6, ATP8 ATP5C1) nigra.Testosterone increased ATP6, ATP5C1 rats.Conversely, orchiectomy downregulated ATP6 expression,...

Pentoxifylline (PTX) is a non-specific phosphodiesterase inhibitor with pleiotropic effects that routinely used to treat peripheral vascular disease. In this study, we tested whether PTX could also counteract the detrimental of aging in brain. To accomplish that, treated aged rats and measured resulting behavioral alterations as well changes dopaminergic neurochemical levels, oxidative balance markers, mitochondrial function, nuclear factor erythroid 2-related 2 (Nrf2), peroxisome...

Aging is a complex phenomenon associated with oxidative stress and mitochondrial dysfunction. The objective of this study was to investigate the potential ameliorative effects phosphodiesterase inhibitor pentoxifylline (PTX) on aging process its underlying mechanisms. We treated D-galactose- (D-gal-) induced mice PTX measured changes in behavior, degree damage, ultrastructure content as well expression nuclear factor erythroid 2-related 2- (Nrf2-) mediated antioxidant genes peroxisome...

The current studies were aimed at evaluating the efficacy of intranasal pentoxifylline (Ptx) pretreatment in protecting mesodopaminergic system and hippocampus from oxidative damage lithium‐pilocarpine induced status epilepticus (SE) involvement nuclear factor erythroid 2‐related 2‐ (Nrf2‐) antioxidant response elements pathway. Pentoxifylline was administered to rats intranasally or intraperitoneally 30 minutes before inducing SE. Our results showed impaired visuospatial memory, defected...

Abstract Nuclear factor erythroid 2 like (Nrf2) functions as a neuroprotective agent in Parkinson's disease ( PD ). This study aimed to investigate the key long non‐coding RNA s (lnc s) correlated with Nrf2, which might provide valuable information for exploration of pathogenesis . The lnc and mRNA expression profiling substantia nigra corpus striatum Nrf2 (−/−) mice model was obtained from microarray analysis. animal experiments conducted this were approved by ethics committee Hebei Medical...

Mitochondrial dysfunction manifests as an early event in the substantia nigra (SN) aging and Parkinson disease. Cyclooxygenase 2 (COX-2), rate-limiting enzyme prostaglandin E2 (PGE2) synthesis pathway, is implicated age-related neurodegenerative diseases; moreover, inhibition of COX-2 expression has been shown to be neuroprotective for nigrostriatal dopaminergic neurons. However, it not known whether effect related improved mitochondrial function during process. To this end, we explored...

Reduced testosterone level is a common feature of aging in men. Aging, as risk factor for several neurodegenerative disorders, shows declined mitochondrial function and downregulated biogenesis dynamics. Mitochondrial dynamics are crucial maintaining proper function. Supplementation with conducive to improving males during aging. Nuclear erythroid 2-related 2 (Nrf2), regulator redox homeostasis, involved the ameliorative effects supplementation upon To explore Nrf2 role on aging, we studied...