A5019350688- Cancer Immunotherapy and Biomarkers
- Hydrogen embrittlement and corrosion behaviors in metals
- Microstructure and Mechanical Properties of Steels
- Esophageal Cancer Research and Treatment
- Welding Techniques and Residual Stresses
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Chinese history and philosophy
- RNA modifications and cancer
- Immune cells in cancer
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Macrophage Migration Inhibitory Factor
- Pancreatic and Hepatic Oncology Research
- Machine Learning in Healthcare
- COVID-19 diagnosis using AI
- Advanced Computational Techniques and Applications
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Educational Reforms and Innovations
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Cloud Computing and Resource Management
- Cancer Genomics and Diagnostics
Soochow University
2023-2025
Jiangsu Cancer Hospital
2021-2024
Nanjing Medical University
2021-2024
First Affiliated Hospital of Soochow University
2024
Ningbo Polytechnic
2005-2022
Zhengzhou University
2011-2022
Second Affiliated Hospital of Nanjing Medical University
2022
Zhejiang University
2009
Zhejiang Academy of Social Sciences
2007
Abstract Tertiary lymphoid structures (TLSs) are considered to have a good prognosis in multiple solid tumors. However, the prognostic value of TLS esophageal squamous cell carcinoma (ESCC) is unknown. In this study, we retrospectively enrolled 185 ESCC patients who underwent surgical resection. Hematoxylin and eosin staining was performed investigate presence, abundance, maturation, location TLSs. We explored cellular composition TLSs using traditional immunohistochemistry serial sections....
Background It has been reported that smoking history as a predictor of immunotherapy efficacy in patients with advanced lung cancer, however, the underlying mechanisms this phenomenon remain largely unknown. Methods The adenocarcinoma’s (LUAD) cohort and orthotopical transplanted mouse model were used to explore correlation between status tertiary lymphoid structure (TLS) chemokine CCL21, respectively. Cell adhesion co-immunoprecipitation assays performed interaction CD4+T cells CD20+B under...
Osimertinib (Osi) is a widely used epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). However, the emergence of resistance inevitable, partly due to gradual evolution adaptive resistant cells during initial treatment. Here, we find that Osi treatment rapidly triggers in tumor cells. Metabolomics analysis reveals significant enhancement oxidative phosphorylation (OXPHOS) adaptive-resistant Mechanically, induces an elevation NCOA4, key protein ferritinophagy, which...
Understanding the stepwise progression of esophageal squamous cell carcinoma (ESCC) is crucial for developing customized strategies early detection and optimal clinical management. Herein, we aimed to unravel transcriptional immunologic alterations occurring during malignant transformation identify clinically significant biomarkers ESCC. Digital spatial profiling (DSP) was performed on 11 patients with early-stage ESCC (pT1) explore in epithelial, immune cell, non-immune stromal compartments...
By applying ferrite–martensite microstructural control, high‐deformability linepipes of grade X70 have been developed. The steel with an acicular ferrite microstructure was intercritically heat‐treated at 820°C for 10 min, followed by rapidly water cooling, in order to get a ferrite/martensite dual‐phase microstructure. After aging 200–250°C 5–15 the and mechanical properties were studied. pipe exhibited superior strain resistance min. yield ratios below 0.77 still continuous yielding...
The microstructure and mechanical properties of X70 pipeline steel with a ferrite/martensite dual-phase produced by thermo-mechanical controlled processing were investigated tensile tests, Charpy V-notched (CVN) impact drop-weight tear guided-bend scanning electron microscopy transmission combined thermodynamic simulation analysis. All the met strength, ductility, toughness deformability requirements grade strain-based design. shear fracture area absorbed energy CVN at −10 °C >97% >205...
BackgroundMalignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due their prevalence and lethality. Treatment methods for NSCLC vary greatly among individuals, making it crucial identify predictive markers. Moreover, during tumour initiation progression, cells can release signaling molecules induce polarization of macrophages towards more friendly M2 phenotype, which promote growth, metastasis, drug resistance.MethodsWe employed...
Despite being the leading cause of lung cancer-related deaths, underlying molecular mechanisms driving metastasis progression are still not fully understood. Transfer RNA-derived fragments (tRFs) have been implicated in various biological processes cancer. However, role tRFs adenocarcinoma (LUAD) remains unclear. Our study identified a tRF, tRF-Val-CAC-024, associated with high-risk component LUAD, through validation using 3 cohorts. findings demonstrated that tRF-Val-CAC-024 acts as an...
This study aims to investigate the effect of initial microstructures on properties ferrite-martensite dual-phase pipeline steels with strain-based design. For this purpose, as-received acicular ferrite were first austenitized at 920 ºC for 15 minutes followed by air cooling and water quenching produce ferrite-pearlite microstructure, respectively. Subsequently, ferrite-pearlite, microstructure intercritically annealed 820 10 three different microstructures. Tensile tests, Vickers hardness...
Objective: To investigate the genetic mutation characteristics of non-small cell lung cancers (NSCLC) with and without lymph node metastasis. Methods: Primary lesions metastatic 36 Chinese NSCLC patients were tested for somatic mutations, tumor burden, phylogenetic clonal evolutional analysis using a 1021-gene panel by next-generation sequencing (NGS) an average depth 671X. Results: In this study, eighteen adenocarcinoma (LUAD) 18 squamous carcinoma (LUSC) included. Different groups had...
Abstract Previous studies revealed that MIR155HG possessed an oncogenic role in many types of tumors including lung adenocarcinoma (LUAD), along with higher expression tumors. However, our study, we observed a positive correlation between and overall survival across different cohorts. The transferred PBMC on the NCG mouse model abrogated tumor intrinsic LUAD. Upregulation positively correlated CD8 + T cell infiltration both vitro vivo, as well LUAD tissues. Mechanistically, increased...
The era of big data (BD) has arrived. How to train models find correlations in and help people make decisions become a major research topic direction. As an elastic scalable distributed computing mode (refers whole consisting multiple interconnected computers that cooperate perform common or different task set system software environments, with minimal reliance on centralized control processes, data, hardware), cloud can provide powerful storage capabilities been widely used BD query...