A5101904034- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Autophagy in Disease and Therapy
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Protist diversity and phylogeny
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Nitrogen and Sulfur Effects on Brassica
First Affiliated Hospital of Soochow University
2014-2024
Soochow University
2013-2024
Circular RNAs (circRNAs) act as microRNA (miRNA) sponges that regulate gene expression and are involved in physiological pathological processes. In this study, we evaluated the roles of circRNAs chemoresistance non-small cell lung cancer (NSCLC) to taxol.High-throughput circRNA microarrays were employed investigate profiles parental A549 taxol-resistant A549/Taxol cells. We predicted miRNA targets differentially expressed via prediction software then constructed a circRNA/miRNA network using...
Abstract In cancer, extrachromosomal circular DNA (ecDNA), or megabase-pair amplified DNA, plays an essential role in intercellular heterogeneity and tumor cell revolution because of its non-Mendelian inheritance. We developed circlehunter ( https://github.com/suda-huanglab/circlehunter ), a tool for identifying ecDNA from ATAC-Seq data using the enhanced chromatin accessibility ecDNA. Using simulated data, we showed that has F1 score 0.93 at 30× local depth read lengths as short 35 bp....
RMP has been shown to function in the transcription regulation through association with RNA polymerase (RNAP) II subunit RPB5. It also be required for proliferation of hepatocellular carcinoma (HCC) cells an antiapoptotic property. In this article, we further demonstrate that displays distinct features HCC compared normal hepatic cells. expression is remarkably increased various cancer cell lines including when Depletion could inhibit cells, but not significantly prevented apoptosis...
Aims: The purpose of this study was to explore the value long noncoding RNA-HOXA transcript antisense RNA myeloid-specific 1 (LncRNA-HOTAIRM1) as a prognostic candidate for detecting non-small cell lung cancer (NSCLC). Materials and Methods: line encyclopedia online database utilized analyze HOTAIRM1 expression in different tumor lines estimate relationship between clinicopathologic parameters based on chi-square test. We compared LncRNA-HOTAIRM1 levels cancerous paracancerous tissues NSCLC...
Objective: To analyze the impact of expression miR-504-3p on proliferation, migration, cell cycle transit and rate apoptosis NSCLC cells explore underlying mechanisms. Methods: The Cancer Genome Atlas (TCGA) database was used to compare levels miR-504 between tissues normal lung tissues. were transfected with lentiviral vectors that either overexpressed or knocked down evaluate its effects biological behavior. Quantitative Real Time Polymerase Chain Reaction measure Interferon-Induced...