A5100355028- Bone Metabolism and Diseases
- Microbial Natural Products and Biosynthesis
- Extracellular vesicles in disease
- Bone health and treatments
- Radiomics and Machine Learning in Medical Imaging
- Marine Sponges and Natural Products
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- S100 Proteins and Annexins
- Microbial Metabolism and Applications
- Fungal Biology and Applications
- Bone and Joint Diseases
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Supramolecular Chemistry and Complexes
- Photoacoustic and Ultrasonic Imaging
- Immune Response and Inflammation
- Sensory Analysis and Statistical Methods
Sichuan University
2022-2025
State Key Laboratory of Oral Diseases
2023-2025
Fujian Institute of Oceanography
2023-2024
Ministry of Natural Resources
2023-2024
Shanghai Jiao Tong University
2017-2024
Tongren Hospital
2024
Hebei Medical University
2024
Fourth Hospital of Hebei Medical University
2024
Hebei General Hospital
2024
Henan Cancer Hospital
2023-2024
Cobalt nickel bimetallic oxides (NiCo2O4) have received numerous attentions in terms of their controllable morphology, high temperature, corrosion resistance and strong electromagnetic wave (EMW) absorption capability. However, broadening the bandwidth is still a huge challenge for NiCo2O4-based absorbers. Herein, unique NiCo2O4@C core-shell microcubes with hollow structures were fabricated via facile sacrificial template strategy. The concentration oxygen vacancies morphologies...
Two novel meroterpenoids, alliisativins A and B (1, 2) were discovered through a genome-based exploration of the biosynthetic gene clusters deep-sea-derived fungus Penicillium allii-sativi MCCC entry 3A00580. Extensive spectroscopic analysis, quantum calculations, chemical derivatization, biogenetic considerations utilized to establish their structures. Alliisativins possess unique carbon skeleton featuring drimane sesquiterpene with highly oxidized polyketide. Noteworthily, alliisativin (1)...
The healthy skeleton requires a perfect coordination of the formation and degradation bone. Metabolic bone disease like osteoporosis is resulted from imbalance and/or resorption. Osteoporosis also reflects lower level matrix, which contributed by up-regulated osteoclast-mediated It reported that monocytes/macrophage progenitor cells or either hematopoietic stem (HSCs) gave rise to multinucleated osteoclasts. Thus, inhibition osteoclastic resorption generally seems be predominant therapy for...
Bone infection is a common and serious complication in the orthopedics field, which often leads to excessive bone destruction non‐union. Osteoclast only type of cells have function resorption. Its over activation closely related loss. Staphylococcus aureus (S. aureus) major pathogen causing infection, can produce large number strong pathogenic substances staphylococcal protein A (SPA). However, few studies were reported about effects SPA on osteoclastogenesis. In our study, we observed that...
Abstract Objective This study aimed to develop a prediction model for esophageal fistula (EF) in cancer (EC) patients treated with intensity-modulated radiation therapy (IMRT), by integrating multi-omics features from multiple volumes of interest (VOIs). Methods We retrospectively analyzed pretreatment planning computed tomographic (CT) images, three-dimensional dose distributions, and clinical factors 287 EC patients. Nine groups different combination omics [Radiomics (R), Dosiomics (D), RD...
Abstract NOD-like receptor family CARD domain containing 3 (NLRC3) is the intracellular protein belonging to NLR (NOD-like receptor) family. NLRC3 can negatively regulate inflammatory signal transduction pathways within adaptive and innate immunocytes. However, studies need elucidate biological role of in bone remodeling. Herein, our study proved that prevents loss by inhibiting TNFα + Th17 cell responses. In osteoporosis, attenuated accumulation marrow. osteoporosis (OP) development was...
Abstract Effects of oxygen vacancies on the optical and electrical properties silicon-based Er doped Ga 2 O 3 films are investigated. The content can be tuned by changing Ar:O flow ratios during sputtering, sputtered in pure Ar proved to possess most calculations energy band structure carrier concentration. It is found that involved process indirect 3+ ions related emission. With more introduced, conductivity transfer efficiency enhanced simultaneously, leading increasing electroluminescence...
Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures elucidated by comprehensive analyses of 1D 2D NMR, HRESIMS, ECD calculations. Compounds 1–17 evaluated for their anti-inflammatory anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on LPS-stimulated nitric oxide production in murine brain microglial BV-2 cells a dose-response manner....
Comprehensive Summary A chemical investigation of the deep‐sea‐derived fungus Penicillium allii‐sativi MCCC 3A00580 resulted in discovery four new meroterpenoids ( 1 — 4 ) and one related known co‐metabolite 5 ). These showcase unique carbon skeletons featuring a common drimane sesquiterpene part with highly diverse polyketide units. Particularly, compound incorporates salicylic acid moiety while 2 possesses rare peroxide bridge part. The structures compounds were assigned by extensive...
This study sought to explore the effect of staphylococcal lipoteichoic acid (LTA) on autophagy in mouse mesenchymal stem cells (MSCs), and then influence osteogenesis through change autophagy. C3H10T1/2 were induced by osteogenic medium with treatment LTA at different concentrations (1, 5, 10 μg/mL); 3-methyladenine (3-MA) used as inhibitor, rapamycin (rapamycin, Rap) activate autophagy; effects detected alkaline phosphatase staining, alizarin red real-time quantitative PCR, western...
Three new polyketides (penidihydrocitrinins A–C, 1–3) and 14 known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures elucidated by comprehensive analyses of 1D 2D NMR, HRESIMS, ECD calculations. Compounds 1–17 evaluated for their anti-inflammatory anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on microglial activation in LPS-stimulated BV-2 cells a dose-response manner. Notably, compound displayed...
Supramolecular macrocycles with intrinsic cavities have been widely explored as containers to fabricate versatile functional materials via specific host–guest recognitions. However, relatively few studies focused on the modulation of guest reactivity within a macrocyclic cavity. Here, we demonstrate confinement effect pillar[5]arene an electron-rich and precise cavity that can dramatically enhance photoactivity nitric oxide (NO) generation upon visible light irradiation. Mechanism reveal it...
Objective: To develop an intervention based on Notch-1 signalling pathway blockade by investigating the potential application of neurogenic locus notch homologue protein 1(Notch-1) as a key regulator chronic inflammation and adipogenesis in treatment hepatic insulin resistance (HIR).
Abstract Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic fractures; however, underlying mechanisms remain unclear. Sensory neuronal signaling plays a crucial role in bone repair. In this study, we aimed investigate pathological hindering fractures, particularly focusing on sensory signaling. We demonstrate that ovariectomized (OVX) mice, loss CGRP + TrkA during correlates with increased Cx3cr1 iOCs expression within callus. Conditional knockout...
Osteogenic differentiation refers to the process of bone formation and remodeling, which is controlled by complex molecular mechanisms. Activin A receptor type I (ACVR1) reported be associated with osteogenic differentiation. However, underlying mechanism remains elusive. Therefore, this study evaluates function ACVR1 in through Wnt signaling pathway. The expression osteocalcin (Oc) osterix together mineralization was examined ACVR1-knockout (KO) mouse. Furthermore, pathway inhibited marrow...
The polarization holographic gratings recorded in Au nanoparticles-doped methyl orange/polyvinylpyrrolidone (MO/PVP) composite films were investigated. state of diffraction beams was controlled by a probe light and together. first-order efficiency the MO/PVP film doped with nanoparticles measured to be 3.2 times larger than that pure film. Meanwhile, an obvious enhancement photoinduced birefringence MO molecules also demonstrated. This discussed terms localized field effect via surface...
To determine whether the peak serum estradiol (E2) level during ovarian stimulation affects cumulative live birth rate (CLBR) and obstetric outcomes in freeze-all cycles. This retrospective cohort study involved patients who underwent their first cycle of vitro fertilization followed by a strategy frozen embryo transfer cycles between January 2014 June 2019 at tertiary care center. Patients were categorized into four groups according to quartiles E2 levels (Q1-Q4). The primary outcome was...
To investigate the prognostic value of bone marrow uptake pattern in
Abstract Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic fractures; however, underlying mechanisms remain unclear. Sensory neuronal signaling plays a crucial role in bone repair. In this study, we demonstrate that ovariectomized (OVX) mice, loss CGRP + TrkA sensory during correlates with increased Cx3cr1 iOCs expression within callus. Conditional knockout restored neuronal, enabling normal progression. Mechanistically, further secrete seme3A...