A5082064802- Cervical Cancer and HPV Research
- Gut microbiota and health
- Renal Diseases and Glomerulopathies
- Neurological Disease Mechanisms and Treatments
- Prenatal Screening and Diagnostics
- Analytical Chemistry and Sensors
- Medicinal Plants and Bioactive Compounds
- Folate and B Vitamins Research
- Genomic variations and chromosomal abnormalities
- Microtubule and mitosis dynamics
- S100 Proteins and Annexins
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Forensic and Genetic Research
- Extracellular vesicles in disease
- Metabolism and Genetic Disorders
- Therapeutic Uses of Natural Elements
- Fetal and Pediatric Neurological Disorders
- Microbial Metabolism and Applications
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- Phytochemistry and Biological Activities
- Iron Metabolism and Disorders
- Analytical Methods in Pharmaceuticals
- Genetic Neurodegenerative Diseases
Guizhou Provincial People's Hospital
2021-2025
Third People's Hospital of Huzhou
2019-2024
Guizhou University
2019-2024
Huzhou University
2019-2024
Chongqing University of Science and Technology
2008-2023
Guiyang Medical University
2013-2022
Henan Cancer Hospital
2019-2020
Zhengzhou University
2019-2020
Shanxi Medical University
2004-2011
Shanxi Fenyang Hospital
2004-2011
Gut microbiota make up the largest microecosystem in human body and are closely related to chronic metabolic diseases. Herein, 520 fecal samples collected from different regions of China, gut microbiome kidney disease (CKD) is characterized, CKD classifiers based on microbial markers constructed. Compared with healthy controls (HC, n = 210), diversity significantly decreased (n 110), community remarkably distinguished HC. Genera Klebsiella Enterobacteriaceae enriched, while Blautia Roseburia...
Bone loss is a hallmark of inflammatory bone diseases caused by aberrantly activated osteoclasts (OCLs). Studies have shown that OCLs exhibit various phenotypes and functions due to variations in the source(s) precursor cells, cytokine expressions, microenvironment-dependent factors. During these conditions, (iOCLs) lose their immune-suppressive effect relative under physiological conditions. This induces TNF α-producing CD4+ T cells an antigen-dependent manner finally leads cascade...
ABSTRACT This study aimed to comprehensively characterize the molecular spectrum of thalassemia by retrospectively analyzing genetic screening results from a large cohort individuals. Peripheral blood samples were collected 26 047 individuals seeking care at Departments Obstetrics and Gynecology, Pediatrics, Reproductive Medicine, Hematology across multiple regional hospitals in Guizhou Province, China. Thalassemia gene mutations analyzed using targeted third‐generation sequencing (TGS)...
Background Abnormal gut microbiota and blood trimethylamine-N-oxide (TMAO) metabolome have been reported in patients with type 2 diabetes mellitus (T2DM) advanced diabetic nephropathy. This study aimed to investigate the profiles a group of targeted urine metabolic characteristics T2DM or without microalbuminuria, determine correlation between composition, trimethylamine (TMA) metabolism, clinical features during progression kidney disease (DKD) Methods included 26 microalbuminuria (Micro),...
Abstract NOD-like receptor family CARD domain containing 3 (NLRC3) is the intracellular protein belonging to NLR (NOD-like receptor) family. NLRC3 can negatively regulate inflammatory signal transduction pathways within adaptive and innate immunocytes. However, studies need elucidate biological role of in bone remodeling. Herein, our study proved that prevents loss by inhibiting TNFα + Th17 cell responses. In osteoporosis, attenuated accumulation marrow. osteoporosis (OP) development was...
Morbidity of chronic kidney disease (CKD) is increased, with many complications and high mortality rates. The characteristics oral microbiome in CKD patients have not been reported. This study aims to analyze the microbiome, demonstrate potential as noninvasive biomarkers for patients.The collected 253 samples from different regions China (Central East China) prospectively finally 235 completed Miseq sequencing, including 103 132 healthy controls (HCs).Compared HCs (n=88), microbial...
Single-nucleotide polymorphisms (SNPs) and DNA methylation are crucial regulators of essential hypertension (EH). Amyloid precursor protein (APP) mutations implicated in development. Nonetheless, studies on the association APP gene polymorphism promoter with limited. Therefore, this case-control aims to evaluate genetic EH Guizhou populations.We conducted a study 343 patients 335 healthy controls (including Miao, Buyi, Han populations) province China analyze 11 single-nucleotide (rs2040273,...
Autosomal Recurrent Primary Microscopic (MCPH, OMIM: 251200) is a neurodevelopmental disorder that characterized by noticeable decrease in brain size, particularly the cerebral cortex, but with normal structure and non-progressive intellectual disability.
Objective: The purpose of this study was to evaluate the effect different combination models high-risk human papilloma viruses (HPV) genotyping in triaging Chinese women with atypical squamous cells undetermined significance (ASCUS). Methods: We established a screening cohort 3997 who underwent cervical cytology and HPV test. Women ASCUS punch biopsy under colposcopy/endocervical curettage. sensitivity, specificity, positive predictive value (PPV), negative (NPV) HR-HPV were calculated that...
To characterize the genetic profiles and relationships between ancient ethnic populations, we analyzed polymorphisms in mitochondrial DNA (mtDNA) isolated from blood of 753 members 12 groups (Buyi, Dong, Gelao, Hui, Man, Miao, Menggu, Mulao, Maonan, Qiang, She Zhuang) living Guizhou Province China. The 9-bp deletion mtDNA was detected by polymerase chain reaction (PCR) PCR-PAGE, 11 SNPs restriction fragment length polymorphism mini-sequencing. Thereafter, these genotyping results were...
More than 50% of prostate cancer (PCa) patients have bone metastasis with osteoblastic lesions. MiR-18a-5p is associated the development and PCa, but it remains unclear whether involved in We first found that miR-18a-5p was highly expressed microenvironment PCa metastases. To address how affects lesions, antagonizing cells or pre-osteoblasts inhibited osteoblast differentiation vitro. Moreover, injection inhibition improved biomechanical properties mineral mass vivo. Furthermore, transferred...
To explore the application of third-generation sequencing (TGS) for genetic diagnosis and prenatal screening thalassemia genes.Two groups subjects were enrolled in this study. The first group included 176 with positive hematological phenotypes thalassemia. Thalassemia-associated genes detected simultaneously each sample using both PacBio TGS platform based on single-molecule real-time (SMRT) technology conventional PCR-reverse dot blot (PCR-RDB). Sanger was used validation when results...
Overview: The treatment of chronic renal failure (CRF) with traditional Chinese medicine has attracted much attention, but its mechanism is not clear. Network pharmacology an effective strategy for exploring the interaction mechanisms between herbs and diseases, however, it still needs to be validated in cell and/or animal experiments due virtual screening characteristics. Herein, anti-CRF Fushengong decoction (FSGD) was investigated using a dual - dimension network pharmacological combined...
The S100 family contains more than 20 Ca2+-binding proteins that participate in numerous cellular biological processes. However, the prognostic value of individual S100s hepatocellular carcinoma (HCC) remains unclear. Therefore, we comprehensively assessed HCC.
Deafness autosomal dominant 2A (DFNA2A) is related to non-syndromic genetic hearing impairment. The KCNQ4 (Potassium Voltage-Gated Channel Subfamily Q Member 4) can lead DFNA2A. In this study, we report a case of loss with six family members as caused by novel variant in the gene.
Carotid-femoral pulse wave velocity (Cf-PWV) can well predict the prognosis of general population. However, whether Cf-PWV be used as a prognostic indicator in maintenance hemodialysis (MHD) patients remains mysterious. The present study endeavored to explore value among MHD Patients who received and underwent examination at center Zhejiang Provincial People's Hospital between March 1, 2017 October 15, 2019 were enrolled. Relevant clinical data collected from these patients, subsequently...