A5076179037- Fluoride Effects and Removal
- Clostridium difficile and Clostridium perfringens research
- Bone and Dental Protein Studies
- Folate and B Vitamins Research
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Bacterial Genetics and Biotechnology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic Associations and Epidemiology
- Bone Tissue Engineering Materials
- Medicinal Plant Pharmacodynamics Research
- Mercury impact and mitigation studies
- Gut microbiota and health
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Ideological and Political Education
- Renin-Angiotensin System Studies
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- MicroRNA in disease regulation
- Oral microbiology and periodontitis research
- Lipoproteins and Cardiovascular Health
Guiyang Medical University
2008-2024
Affiliated Hospital of Guizhou Medical University
2023
Clostridioides difficile is a Gram-positive, spore-forming anaerobic bacteria that one of the leading causes antibiotic-associated diarrhea. The cell wall protein 66 gene (cwp66) encodes protein, which second major surface antigen C. difficile. Although immunological approaches, such as antibodies and purified recombinant proteins, have been implemented to study role Cwp66 in adhesion, no deletion mutant cwp66 has yet characterized. We constructed using Clustered Regularly Interspaced Short...
MicroRNAs (miRNAs/miRs) have been reported to affect ischemia/reperfusion (I/R)‑induced cerebral damage. miRNAs cause post‑transcriptional gene silencing by binding the protein‑coding sequence (CDS) of mRNAs. Seipin has a potential role in regulating autophagic flux. The present study investigated involvement miR‑187‑3p expression, flux and apoptosis vitro, as well underlying mechanism, using PC12 cells exposed oxygen‑glucose deprivation/reoxygenation (OGD/R), which mimicked process I/R. In...
Single-nucleotide polymorphisms (SNPs) and DNA methylation are crucial regulators of essential hypertension (EH). Amyloid precursor protein (APP) mutations implicated in development. Nonetheless, studies on the association APP gene polymorphism promoter with limited. Therefore, this case-control aims to evaluate genetic EH Guizhou populations.We conducted a study 343 patients 335 healthy controls (including Miao, Buyi, Han populations) province China analyze 11 single-nucleotide (rs2040273,...
Coal-burning fluorosis is a chronic poisoning resulting from the prolonged use of locally available high-fluoride coal for heating and cooking. Prolonged fluoride exposure has been demonstrated to decrease PPARGC1A levels. Therefore, this case-control aims evaluate genetic association gene polymorphisms methylation mitochondrial D-loop region with coal-burning fluorosis.
Objective A case-control study was conducted to evaluate the relationship between endothelial nitric oxide synthase ( NOS3 ) gene polymorphism and essential hypertension in Han, Miao, Buyi populations Guizhou China. Methods DNA collected from blood samples of 353 patients 342 healthy controls province Eight polymorphisms were genotyped using Sequenom MassARRAY platform. For genetic analysis, SPSS 26.0, Haploview, SNPStats, SHEsis, MDR utilized. Results All SNPs (rs11771443, rs1808593,...
Objective. To explore the function and mechanism of Sirt-1 in fluorine-induced liver injury. Method. Fluorosis rats were first established. The fluorine content, pathological structure, collagen fibers, fibrosis tissues tested through fluoride ion selective electrode method, H&E, Masson, Sirius red staining; alanine aminotransferase (ALT), aspartate (AST), interleukin 18 (IL-18), tumor necrosis factor-α (TNF-α) levels rat serum also analyzed using ELISA kits. Then, fluorosis cell model...
Abstract Background Clostridium difficile infection (CDI) is the leading cause of nosocomial diarrhea. Co-colonization key bacterial taxa may prevent transition from asymptomatic C. colonization to CDI. However, little known about composition in patients. Methods In present study, culture method was used examine stool microbiota two patients Guizhou, China. Results A total 111 strains were isolated and phylogenetic relationships determined by 16S ribosomal gene sequencing Molecular...
Dental fluorosis, resulting from long-term environmental exposure to fluoride, is prevalent among diverse populations worldwide. Severe fluorosis not only compromises the aesthetic appeal of teeth but also impairs their functionality. This study aims investigate oral microbiome in dental and health individuals adolescents living endemic area Guizhou, China through full-length 16S rDNA sequencing. Fourty-six meet sampling criteria, we divided these samples into following groups: a healthy...
Thermophilic group II intron is one type of retrotransposon composed RNA and intron-encoded protein (IEP), which can be utilized in gene targeting by harnessing their novel ribozyme-based DNA integration mechanism termed "retrohoming." It mediated a ribonucleoprotein (RNP) complex that contains the excised lariat an IEP with reverse transcriptase (RT) activity. The RNP recognizes sites exon-binding sequences 2 (EBS2)/intron-binding (IBS2), EBS1/IBS1, EBS3/IBS3 bases pairing. Previously, we...
Objective To investigate ethnic belonging, family economic status, staple food, dental fluorosis and urinary fluoride level of primary school students in Douqing Minority (Miao Yi) Village, where is a severity area coal-burning type endemic fluorosis, order to provide base for diminishing the disease minorities lived cold plateau regions. Methods We invited directors various classes fill questionnaire tables. According situations annual income student health conditions families, we...
Abstract Background To investigate the correlation between single nucleotide polymorphism (SNP) of human Apolipoprotein E (ApoE) gene and essential hypertension (EH) in Han, Miao, Buyi populations Guizhou. Methods A case–control study was conducted. total 343 patients with EH 335 healthy controls were selected from Leishan Libo Buyi, Guiyang Han The clinical data biochemical indicators including age, gender, height, weight, fasting blood glucose, cholesterol, triglyceride collected. t test...