A5043203800- Influenza Virus Research Studies
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Respiratory viral infections research
- Gestational Diabetes Research and Management
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Hepatitis B Virus Studies
- Protein Interaction Studies and Fluorescence Analysis
- Leptospirosis research and findings
- Cooperative Studies and Economics
- Cardiac, Anesthesia and Surgical Outcomes
- vaccines and immunoinformatics approaches
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Birth, Development, and Health
- Plant Pathogens and Fungal Diseases
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- Liver physiology and pathology
- Customer Service Quality and Loyalty
- thermodynamics and calorimetric analyses
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
Wenzhou Medical University
2021-2024
First People’s Hospital of Jingmen
2024
Huazhong University of Science and Technology
2009-2023
Capital Medical University
2023
Central Hospital of Wuhan
2021-2023
Sichuan University
2022-2023
University of Electronic Science and Technology of China
2023
Qingdao Agricultural University
2009-2022
Guizhou University
2020
China Southern Power Grid (China)
2019
Current hepatocellular carcinoma (HCC) risk scores do not reflect changes in HCC resulting from liver disease progression/regression over time. We aimed to develop and validate two novel prediction models using multivariate longitudinal data, with or without cell-free DNA (cfDNA) signatures.A total of 13,728 patients nationwide multicenter prospective observational cohorts, the majority whom had chronic hepatitis B, were enrolled. aMAP score, as one most promising models, was evaluated for...
Insulin resistance is a powerful risk factor for Type 2 diabetes and constellation of chronic diseases, most commonly associated with obesity. We examined if factors other than obesity are more substantial predictors insulin sensitivity under baseline, nonstimulated conditions.Metabolic assessment was performed in healthy dogs (n = 90). Whole-body from euglycemic clamps (SICLAMP ) the primary outcome variable, measured independently by IVGTT 36). Adiposity MRI 90), glucose-stimulated...
The translocation of photoassimilates is a critical process that links the source and sink in plants, playing an irreplaceable role maintaining source-sink balance, ensuring plant growth development, formation yield. Nevertheless, mechanisms underlying photosynthetic products macroalgae are yet to be fully understood. purpose this study reveal endocytosis marine red alga Gracilariopsis lemaneiformis by investigating uptake impact endocytic activity on cellular ultrastructure, photosynthesis,...
Anaplastic large cell lymphoma (ALCL) is a rare type of peripheral T-cell lymphoma, accounting for small percentage adult and childhood lymphomas. The scarcity reports on relapsed or refractory ALCL in children, especially with complex karyotypes, highlights the need detailed case studies. We report 9-year-old girl diagnosed ALK-positive anaplastic complicated by karyotype abnormalities bone marrow involvement. patient underwent multiple chemotherapy regimens, including P regimen, AV1, BV1,...
Machine learning (ML) shows great promise in protein engineering but has yet to be integrated with ultra-high throughput sorting (ultra-HTS) and NGS for large-scale sequence-function data generation harness its capability explore wider search space more complex mutation events. Here, we introduce PUSDA, a framework that rapidly sorts mutant libraries into multiple performance groups good accuracy generates power ML-driven design. As demonstration, PUSDA generated over five million of an...
Abstract Purpose: Intratumoral hepatitis B virus (HBV) integrations and mutations are related to hepatocellular carcinoma (HCC) progression. Circulating cell-free DNA (cfDNA) has shown itself as a powerful noninvasive biomarker for cancer. However, the HBV integration mutation landscape on cfDNA remains unclear. Experimental Design: A cSMART (Circulating Single-Molecule Amplification Resequencing Technology)-based method (SIM) was developed simultaneously investigate landscapes with...
We selected the conserved sequence in stalk region of influenza virus hemagglutinin (HA) trimmer, long alpha helix (LAH), as vaccine candidate sequence, and inserted it into major immunodominant (MIR) hepatitis B core protein (HBc), and, by using E. coli expression system, we prepared a recombinant LAH-HBc form virus-like particles (VLP). Intranasal immunization mice with this VLP plus cholera toxin subunit 0.2% (CTB * ) adjuvant could effectively elicit humoral cellular immune responses...
Background The relationship between hyperlactatemia and prognosis after cardiopulmonary bypass (CPB) is controversial, some studies ignore the presence of lactic acidosis in patients with severe hyperlactacemia. This study explored association (LA) occurrence multiple organ dysfunction syndrome (MODS) bypass. Methods was a post hoc analysis who underwent cardiac surgery February 2017 August 2018 participated prospective at Taizhou Hospital. data were collected at: ICU admission (H0), 4, 8,...
Adipocyte size plays a key role in the development of insulin resistance. We examined longitudinal changes adipocyte and distribution visceral (VIS) subcutaneous (SQ) fat during obesity-induced resistance after treatment with CB-1 receptor antagonist, rimonabant (RIM) canines. also whether and/or is predictive morphology was assessed by direct microscopy analysis digital images previously studied animals 6 weeks high-fat diet (HFD) 16 HFD + placebo (PL; n = 8) or RIM (1.25 mg/kg/day; 11). At...
Abstract Background We examined the association between metabolically healthy obese (MHO) and diabetes incidence in a middle‐aged elderly population whether differed by presence of nonalcoholic fatty liver disease (NAFLD). Methods 17 801 participants without at study entry (7980 males 9821 females with mean age 63.2 years) derived from Dongfeng‐Tongji cohort (median follow‐up: 4.6 years). Participants were divided into six groups based on BMI (normal weight, overweight, or obese) metabolic...
Hepatic stellate cells (HSCs) play a key role in the development of liver fibrosis caused by schistosomiasis. Chemokines were widely expressed and involved cellular activation, proliferation migration inflammatory infectious diseases. However, little is known about expressions chemokines on HSCs schistosoma infection. In addition, roles pathogenesis are not totally clear. our study, we used microarray to analyze temporal gene primary isolated from mice with both acute chronic Our data showed...
Abstract Background The highly conserved nucleoprotein (NP) is an internal protein of influenza virus and capable inducing cross-protective immunity against different A viruses, making it a main target universal vaccine. In current study, we characterized the immune response induced by DNA prime-intranasal boost strategy based on NP (A/PR/8/34, H1N1) in mouse model, evaluated its protection ability lethal dose challenge virus. Results intranasal with recombinant (rNP) could effectively...
There is an ongoing debate on the declining semen quality, and unfortunately, existing evidence inconclusive inconsistence. We evaluated impact of sociodemographic characteristics, lifestyle, medical history work exposure quality. Univariate multivariate analysis was used to investigate association between different risk factors quality parameters. Total sperm count (p = 0.041), concentration 0.007), normal morphology 0.002), total motility 0.004) progressive 0.009) decreased in men with...