A5103198332- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Nerve injury and regeneration
- RNA modifications and cancer
- Analytical chemistry methods development
- RNA Research and Splicing
- Pain Mechanisms and Treatments
- Plant Reproductive Biology
- Pregnancy and preeclampsia studies
- Eosinophilic Esophagitis
- Signaling Pathways in Disease
- Reconstructive Surgery and Microvascular Techniques
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
- Genomics and Chromatin Dynamics
- Electrochemical sensors and biosensors
- Pregnancy-related medical research
- Infrared Target Detection Methodologies
- Cancer, Stress, Anesthesia, and Immune Response
- Photosynthetic Processes and Mechanisms
- Hydrogen's biological and therapeutic effects
- Autophagy in Disease and Therapy
- Ectopic Pregnancy Diagnosis and Management
Foshan Maternity and Child Health Care Hospital
2020-2025
Southern Medical University
2020-2024
Sichuan Academy of Agricultural Sciences
2024
Rice Research Institute
2021-2024
Southwest University
2021-2024
Guangdong Medical College
2024
Union Hospital
2015-2022
Jilin University
2015-2022
Maternity and Children's Hospital
2022
Union Hospital
2019-2021
Ketamine is widely used for cancer pain treatment in clinic, and has been shown to inhibit various tumor cells growth. However, the effect of ketamine on ovarian growth downstream molecules not defined. In present study, we found that significantly inhibited proliferation survival six cell lines. Moreover, induced cycle arrest, apoptosis, colony formation capacity. Since lncRNAs have identified as key regulators development, performed bioinformatics analysis a GEO dataset fourteen altered...
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. ) have been reported to play an important role various diseases inflammation response processes.However, whether miR-15a/16 participates regulation neuroinflammation pain remains unknown.In this study, we established a mouse model by chronic constriction injury (CCI) sciatic nerves.Our results showed both miR-15a miR-16 expression was significantly...
Colorectal carcinoma (CRC) is a malignant solid tumor arising from the large intestine and associated with an increasing incidence poor prognosis. Further understanding of molecular mechanisms underlying CRC may contribute to development novel effective therapeutic strategies. MicroRNAs (miRs), including miR‑155, have been reported be etiology biology CRC; however, by which miR‑155 affect remain fully elucidated. The present study used multidisciplinary approach, involving reverse...
Abstract The biological roles of intravenous anaesthetic propofol in cancer have been shown by various studies using cell lines that represent differentiated cells. However, the activities stem cells not elucidated. In this work, we examined effects and mechanisms on acute myeloid leukaemia ( AML ) CD 34 + 38 − We found inhibited growth, differentiation self‐renewal capabilities regardless cellular origin genetic profiling. addition, growth Propofol significantly induced apoptosis but...
This study aimed to investigate the effect of miR-206 on apoptosis and autophagy cardiomyocytes in ischaemia/reperfusion (I/R) injured rats treated with sevoflurane post-conditioning (SP) through AMPK/Nampt signalling pathway. Rat models myocardial I/R injury were established. The combination SP, inhibitor, AMPK activator AICAR inhibitor Compound C was induced rats, their effects determined detection malondialdehyde (MDA), hydroxyproline (HYP) superoxide dismutase (SOD) levels...
The aim of the present study was to identify differentially expressed microRNAs (DEMs) between Lynch syndrome (LS) and normal colonic (N-C) control samples, predict target genes (TGs) analyze potential functions DEMs TGs. miRNA expression dataset GSE30454, which included data 13 LS 20 N-C tissue downloaded from Gene Expression Omnibus. classical t-test in Linear Models for Microarray Data package used DEM identification. TG prediction performed using 5 databases. regulatory network their TGs...
To compare the maternal and neonatal outcomes of placenta previa (PP) with without coverage a uterine scar in Foshan, China.A retrospective cohort study comparing all singleton pregnancies PP was conducted at tertiary, university-affiliated medical center from 1 January 2012 to 31 April 2017 China. Demographic, clinical laboratory data were extracted electronic records (EMRs). Maternal compared by statistical method.There 58,062 deliveries during period, which 726 (1.25%) complicated further...
The effect of histone deacetylase (HDAC)2/Inositol polyphosphate‑5‑phosphatase F (Inpp5f) on neuropathic pain and cognitive dysfunction through regulating PI3K/Akt/GSK‑3β signal pathway in rats with was investigated. A total 80 SPF mature male SD were averagely randomized into the sham operation group, model HDAC2 intervention group (group A) Inpp5f B). rat models established groups B. At 15th day after modeling, transfected interference vector HDAC2, B overexpression Inpp5f. Rats four...
Objective: To explore the size and shape association of OGTT values with adverse pregnancy complications among women gestational diabetes mellitus (GDM) in Southern Han Chinese population further analyze their mediating effects maternal age outcomes. Methods: 6861 GDM were included study. Logistic regression was used to identify correlations between outcomes GDM. Restricted cubic spline nested logistic conducted investigate potential non-linear linear associations. Mediating effect age,...
Previous evidence suggests that higher blood uric acid (UA) levels are associated with adverse cardiovascular outcomes during pregnancy and subsequent birth outcomes. However, it has been relatively unclear whether these associations persist in normotensive pregnant women.The study was based on a retrospective analysis of 18,250 mother-infant pairs large obstetric center China. Serum UA concentrations early (median: 17.6, IQR: 16.3, 18.6 gestational weeks) were assessed. Hyperuricemia...
Abstract Background Mitochondria are vital regulators of plant growth and development, constitute the predominant source ATP, participate in multiple anabolic catabolic metabolic pathways. But mechanism by which dysfunctional mitochondria affect remains unknown, more mitochondria-defective mutants need to be identified. Results A mutant decreased vascular bundle 1 ( dvb1 ) was isolated from rice library mutagenized EMS (ethylmethane sulfonate), shows dwarfism, narrow leaves, short branches,...
Objective: Serum response factor (SRF), a sequence-specific transcription factor, is closely related to metastasis of gastric cancer, digestive tract cancer.Herein, we probed the effect SRF on and progression colon cancer (CC), another disorder, detailed mechanism.Methods: Microarray analysis was conducted tumor adjacent tissues filter differentially expressed miRNA, followed by RT-qPCR validation in CC cell lines.The target gene microRNA-214 (miR-214) were predicted, their binding...
Gene expression profiles of CD133-positive cells from patients with coronary artery disease (CAD) were analyzed to identify key genes associated cardiac therapy. Furthermore, the effect exercise on gene was also investigated. data set (accession number: GSE18608) downloaded Expression Omnibus, including blood samples four healthy subjects (H), and 10 at baseline (B) after 3 months (3M) exercise. Differential analysis performed for H vs. B 3M using limma package R. Two‑way cluster levels...
The infection of Helicobacter pylori (H. pylori) is one the most important causes gastric ulcer disease. role hydrogen sulfide (H2S) production in H. pylori-induced disease.The expression cystathionine-γ-lyase (CSE) was determined, and correlated with severity disease.One hundred eight patients were selected based on determination pylori), including 36 normal control, Pylori-negative ulcer, Pylori-positive ulcer. RT-PCR performed to determine CSE, NF-κB IL-8.The IL-8 higher group than...
Objective: To investigate the effects of exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC) on proliferation and invasion capacities uterine fibroblast cells. Methods: Exosomes were isolated hUC-MSC culture medium via ultracentrifugation. The morphology, particle size, surface markers hUC-MSC-derived (hUC-MSC-exo) characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Western blotting. impact was assessed CCK-8 assay...