A5100778170- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Pulmonary Hypertension Research and Treatments
- Peripheral Artery Disease Management
- Cytokine Signaling Pathways and Interactions
- Vascular Procedures and Complications
- Cell Adhesion Molecules Research
- Retinoids in leukemia and cellular processes
- Central Venous Catheters and Hemodialysis
- Kruppel-like factors research
- RNA modifications and cancer
- Biomedical Research and Pathophysiology
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Bladder and Urothelial Cancer Treatments
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- Corneal Surgery and Treatments
- Genetic and Kidney Cyst Diseases
Foshan Maternity and Child Health Care Hospital
2025
Jiading District Central Hospital
2025
Ruijin Hospital
2024
Shanghai Jiao Tong University
2011-2024
Icahn School of Medicine at Mount Sinai
2013-2024
New York Consortium in Evolutionary Primatology
2024
China Pharmaceutical University
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2011-2024
Anhui Provincial Children's Hospital
2024
Renji Hospital
2024
ABSTRACT The vitamin E analog α‐tocopheryl succinate (α‐TOS) can induce apoptosis. We show that the proapoptotic activity of α‐TOS in hematopoietic and cancer cell lines involves inhibition protein kinase C (PKC), since phorbol myristyl acetate prevented α‐TOS‐triggered More selective effectors indicated reduced PKCα isotype by increasing phosphatase 2A (PP2A) activity. role α‐TOS‐induced apoptosis was confirmed using antisense oligonucleotides or overexpression. Gain‐ loss‐of‐function bcl‐2...
Reconstruction of the aortic major branches during thoracic endovascular repair is complicated because complex anatomic configuration and variation arch. In situ laser fenestration has shown great potential for revascularization branches. This study aims to evaluate feasibility, effectiveness, safety in on three arch repair.Before clinical application, polytetrafluoroethylene Dacron grafts were fenestrated by an 810-nm system ex vivo, which did not damage bare metal portion endografts...
Acetyl-keto-beta-boswellic acid (AKBA), a triterpenoid isolated from Boswellia carterri Birdw and serrata, has been found to inhibit tumor cell growth induce apoptosis. The apoptotic effects the mechanisms of action AKBA were studied in LNCaP PC-3 human prostate cancer cells. induced apoptosis both lines at concentrations above 10 microg/mL. AKBA-induced was correlated with activation caspase-3 caspase-8 as well poly(ADP)ribose polymerase (PARP) cleavage. increased levels death receptor (DR)...
Cancer stem cell behavior is thought to be largely determined by intrinsic properties and regulatory signals provided the microenvironment. Myelofibrosis (MF) characterized hematopoiesis occurring not only in marrow but also extramedullary sites such as spleen. In order study effects of these different microenvironments on primitive malignant hematopoietic cells, we phenotypically functionally splenic peripheral blood (PB) MF CD34+ cells from patients with MF. spleens contained greater...
Summary Panobinostat ( LBH 589), a novel histone deacetylase inhibitor HDAC i), was evaluated in phase I study of patients with primary myelofibrosis PMF ) and post‐essential thrombocythaemia/polycythaemia vera‐related (Post‐ ET / PV MF ). Eighteen 56%; Post‐ 28%; 17%) were treated three cohorts at oral doses (i) 20, (ii) 30, (iii) 25 mg times weekly consecutively. Reversible thrombocytopenia the dose‐limiting toxicity. Five (two Dose Cohort 1, one 2 two 3) received six or more cycles...
Abstract The Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and the prefibrotic form of primary myelofibrosis (PMF), frequently progress to more overt forms MF a type acute leukemia termed MPN-accelerated phase/blast phase (MPN-AP/BP). Recent evidence indicates that dysregulation tumor suppressor protein p53 (TP53) commonly occurs in MPNs. proteins MDM2 MDM4 alter cellular levels TP53. We investigated...
Efforts to unravel the mechanisms underlying taste sensation (gustation) have largely focused on rodents. Here we present first comprehensive characterization of gene expression in primate buds. Our findings reveal unique new insights into biology We generated a bud database using laser capture microdissection (LCM) procured fungiform (FG) and circumvallate (CV) buds from primates. also used LCM collect top bottom portions CV Affymetrix genome wide arrays were analyze all samples. Known...
Taste bud cells transmit information regarding the contents of food from taste receptors embedded in apical microvilli to gustatory nerve fibers innervating basolateral membranes. In particular, depolarize, activate voltage-gated sodium channels, and fire action potentials response tastants. Initial cell depolarization is attributable influx through TRPM5 sweet, bitter, umami an undetermined cation ion channel sour expressing PKD2L1, a candidate receptor. The molecular identity channels that...
Abstract Primary myelofibrosis (PMF) and polycythemia vera (PV) are chronic myeloproliferative neoplasms. PMF and, to a lesser degree, PV characterized by constitutive mobilization of hematopoietic stem cells (HSC) progenitor (HPC) into the peripheral blood (PB). The interaction between chemokine CXCL12 its receptor CXCR4 plays pivotal role in determining trafficking CD34+ bone marrow (BM) PB. PMF, but not PV, is associated with downregulation due epigenetic events. Both patients have...
β-glucans have been considered the major bioactive components in Qingke (Tibetan hulless barley). However, structure–function relationships of from seldom investigated. Whether bioactivities are closely correlated to their molecular weights remains unknown. Therefore, order explore as functional/healthy food ingredients for industrial applications, and better understand relationships, correlations vitro binding properties, inhibitory activities on digestive enzymes (α-amylase pancreatic...