A5101443360- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Kruppel-like factors research
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Underwater Vehicles and Communication Systems
- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- Neuroscience and Neural Engineering
- Leaf Properties and Growth Measurement
- Fatigue and fracture mechanics
- Hedgehog Signaling Pathway Studies
- Environmental DNA in Biodiversity Studies
- T-cell and B-cell Immunology
- Remote Sensing and Land Use
- Water Quality Monitoring Technologies
- Planarian Biology and Electrostimulation
- Electromagnetic Fields and Biological Effects
North University of China
2025
Hangzhou Normal University
2023-2024
Jiangsu University
2023-2024
Zhejiang Provincial Institute of Communications Planning,Design & Research
2024
Affiliated Hospital of Hangzhou Normal University
2023
Beijing Jiaotong University
2023
Guangzhou Medical University
2023
University of Cincinnati Medical Center
2014-2022
Southern Medical University
2015-2022
Tianjin First Center Hospital
2022
Abstract TET2 is a dioxygenase that catalyses multiple steps of 5-methylcytosine oxidation. Although mutations frequently occur in various types haematological malignancies, the mechanism by which they increase risk for these cancers remains poorly understood. Here we show Tet2 −/− mice develop spontaneous myeloid, T- and B-cell malignancies after long latencies. Exome sequencing tumours reveals accumulation numerous mutations, including Apc , Nf1 Flt3 Cbl Notch1 Mll2 are recurrently...
Abstract Large skin wounds are one of the most important health problems in world. Skin wound repair and tissue regeneration complex processes involving many physiological signals, effective healing remains an enormous clinical challenge. Therefore, there is urgent need for a strategy to rapidly kill bacteria, promote cell proliferation accelerate healing. At present, electrical stimulation (ES) often used treatment can simulate endogenous biological current body process wounds. However,...
In addition to neuroprotective strategies, neuroregenerative processes could provide targets for stroke recovery. However, the upregulation of inhibitory chondroitin sulfate proteoglycans (CSPGs) impedes innate regenerative efforts. Here, we examine regulatory role PTPσ (a major proteoglycan receptor) in dampening post-stroke Use a receptor modulatory peptide (ISP) or Ptprs gene deletion leads increased neurite outgrowth and enhanced NSCs migration upon CSPG substrates. Post-stroke ISP...
Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically the CSF1R receptor with its inhibitor (PLX5622). Both widely used in recent years define essential functions of and led high impact studies that moved field forward.Using Cx3cr1-iDTR mice combination Dtx via PLX5622 diet we compared two MRI histology study general anatomy brain CSF/ventricular systems....
The reverse addition process in anti-solvent crystallization is safer and more efficient than sieving when dealing with energetic compounds. A new mathematical model has been developed to understand the crystal size mechanism during of solvent a binary system. This incorporates droplet dynamics, distribution moments, mass balance constraints. It can be used predict appropriate for designing explosive recipes desired particle maximize energy output. was validated by conducting...
The abnormal trafficking of CD34+ cells is a unique characteristic primary myelofibrosis (PMF). We have further studied the behavior PMF by examining their homing to marrow and spleens nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Following infusion normal granulocyte colony-stimulating factor-mobilized peripheral blood (mPB) into NOD/SCID mice, reduced numbers granulocyte-macrophage colony-forming unit (CFU-GM) compared with mPB were detected in these whereas similar...
Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by destruction of synovial joints, abnormal immune responses and chronic inflammatory manifestations, which seriously affects patients’ well-being. We explored this study to ascertain the effect mechanism silent information regulator 6 (SIRT6) on RA. Methods: Genes RA patients normal volunteers were analyzed using Gene Expression Omnibus (GEO), Kyoto-Encyclopedia Genomes (KEGG) Disconet databases. Serum samples...
Natural occurring anthraquinone like chrysophanol has been studied because of its anti-diabetic, anti-tumor, anti-inflammatory, hepatoprotective and neuroprotective properties. Nonetheless, poor water solubility unstable nature are big concerns in achieving efficient delivery associated pharmacokinetic pharmacodynamic effects. Herein, this study sought to solve the above-mentioned problem through development chrysophanol-loaded nanoparticles enhance bioavailability evaluate anti-renal...
Abstract From the point of view systems biology, insight into controlling functioning biological is conducive to understanding their complexness. The development novel devices, instrumentation and approaches facilitates this endeavor. Here, we show a transistor-like device that can be used control kinetics consumption glucose at yeast-immobilised electrode. gating voltage applied an insulated electrode was both rate production ATP ethanol, end-products normal metabolism. Further, correlation...
Rotate vector (RV) reducers are the two-stage deceleration device comprising involute and cycloid-pin gear transmission mechanisms. As typical elements, they widely applied in industrial robots, digitally controlled machine tools automation fields due to their compact structure high precision. However, a reducer may lose precision after long-term operation. Moreover, pitting metal peeling of internal components also occur, leading fatigue failure. Therefore, it is necessary conduct...
This study is designed to assess the protective cardiac effects after myocardial infarction (MI) of (i) cardiovascular progenitor cells (PC) differentiated directly into cardiomyocytes (CM) and endothelial (ECs) at injury site, as separable from (ii) paracrine factors released PC.In vivo: bi-cell patch containing induced pluripotent stem cell (iPSC)-derived CM EC (BIC) was transplanted onto infarcted heart. BIC were transduced with herpes simplex virus thymidine kinase "suicide" gene driven...
In the bone marrow (BM) microenvironment, NG2 + /Nestin mesenchymal stem cells (MSCs) promote hematopoietic cell (HSC) quiescence 1,2 . Importantly, BM can also harbour disseminated tumour (DTCs) from multiple cancers, which, like HSCs, remain dormant 3 The signals are so growth-restrictive that DTCs persist for years to decades only awaken and fuel lethal metastasis 3–10 mechanisms niche components regulating DTC dormancy largely unknown. Here, we reveal periarteriolar BM-resident MSCs...