A5100625145- Aortic aneurysm repair treatments
- Chronic Myeloid Leukemia Treatments
- Aortic Disease and Treatment Approaches
- Central Venous Catheters and Hemodialysis
- Bone Tumor Diagnosis and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Cancer Cells and Metastasis
- Vascular Procedures and Complications
- Infectious Aortic and Vascular Conditions
- Cardiac Arrhythmias and Treatments
- Sarcoma Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Hemodynamic Monitoring and Therapy
- Lymphoma Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Advanced Breast Cancer Therapies
- Cutaneous lymphoproliferative disorders research
- Rabies epidemiology and control
- Circadian rhythm and melatonin
- Anorectal Disease Treatments and Outcomes
- Diagnosis and Treatment of Venous Diseases
- Cancer-related molecular mechanisms research
Chengdu University of Traditional Chinese Medicine
2023-2024
Quest Diagnostics (United States)
2023
Shanghai Jiao Tong University
2012-2022
Shanghai Ninth People's Hospital
2012-2022
Zhejiang University
2022
Cyclerion (United States)
2021
National Engineering Research Center for Compounding and Modification of Polymer Materials
2018-2021
Baoding People's Hospital
2019
China National GeneBank
2018
BGI Group (China)
2018
Reconstruction of the aortic major branches during thoracic endovascular repair is complicated because complex anatomic configuration and variation arch. In situ laser fenestration has shown great potential for revascularization branches. This study aims to evaluate feasibility, effectiveness, safety in on three arch repair.Before clinical application, polytetrafluoroethylene Dacron grafts were fenestrated by an 810-nm system ex vivo, which did not damage bare metal portion endografts...
Juvenile amyotrophic lateral sclerosis (JALS) occurs at an age of onset below 25 years with a heterogeneous disease location, variable progression and survival time. To investigate whether ALS gene profile could resolve any aspects clinical symptom heterogeneity, we have used targeted sequencing technology in cohort 12 JALS patients Chinese descent. We detected 5 likely pathogenic mutations, 2 familial probands 3 sporadic patients. One was known TARDBP mutation (p.G348V) 4 were FUS...
The growth hormone secretagogue receptor (GHSR) plays an important role in regulating food intake and energy homeostasis. In this study, we compared the pharmacological properties of four reported variants human GHSR (I134T, V160M, A204E, F279L) with those wild-type receptor. Corresponding recombinant receptors were transiently expressed either embryonic kidney 293 or COS-7 cells. Basal as well ligand-induced signaling was assessed by luciferase reporter gene assays measurement inositol...
Inflammation in the central nervous system (CNS) is observed many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling plays an essential role modulating neuroinflammation. CYR119 a CNS-penetrant sGC stimulator that amplifies endogenous NO-sGC-cGMP signaling. We evaluated target engagement and effects of on markers neuroinflammation vitro mouse microglial cells vivo quinolinic acid (QA)-induced high-fat diet-induced rodent...
Objective Shunt infection is a common complication while treating hydrocephalus. The antibiotic-impregnated shunt catheter (AISC) was designed to reduce rate. A meta-analysis conducted study the effectiveness of AISCs in reduction terms age, follow-up time and high-risk patient population. Methods This reviewed literature from three databases including PubMed, EMBASE, Cochrane Library (from 2000 March 2019). Clinical studies controlled trials for operation were included this analysis....
Triple-negative breast cancer (TNBC) is extremely aggressive and associated with poor prognosis. There are no known predictive or prognostic markers for TNBC. Inhibition of tumor protein P53 (TP53) has been demonstrated to increase the levels cluster differentiation 117 (CD117) in human colorectal cells. However, function TP53 regulation CD117 TNBC has, best our knowledge, not reported. In present study, association between expression mutations was investigated, their value patients...
Abstract Background To assess the efficacy and safety of preoperative embolization (PE) in patients with carotid body tumor (CBTs). Methods In a single‐center retrospective cohort study, 127 underwent surgical resection CBTs from January 2003 to December 2019. One‐to‐one propensity score matching was conducted between or without PE. Results Thirty‐two (25.2%) received After matching, no statistically significant differences were found baseline characteristics 28 each group. Compared NPE...
In January 2016, two patients died of rabies after receiving kidney transplants from a common organ donor at hospital in Changsha, Hunan, China. The medical records, epidemiological data the donor, and liver recipients were reviewed. Intravitam saliva samples tested for virus (RABV) using real-time RT-PCR, nucleoprotein (N) gene was amplified sequenced by Sanger sequencing. Whole genome sequences analyzed next-generation N genes showed 100% nucleic acid identity. Phylogenetic analysis...
The aim of this study was to develop a temperature-induced polyethylene glycol (PEG) water phase/polysaccharide water-phase emulsion approach for preparing interferon alpha-2b (IFNα-2b)-loaded polysaccharide nanoparticles.IFNα-2b first added mixture an aqueous solution PEG and polysaccharide.The stirred in magnetic stirrer at rate 2000 rpm 45 seconds 0°C ± 0.5°C.The then prefrozen different temperatures.The IFNα-2b partitioned the phase were preferentially separated out as dispersed from...
The aim of this paper was to retrospectively evaluate the procedural and clinical outcomes after staged angioplasty in high-risk, chronic, critical limb ischemia (CLI) patients.Between 2013 2015, 29 patients (29 limbs) (mean age 77 years) were treated by revascularization procedures 1) iliac artery-DFA alone or with femoropopliteal artery followed 2) a below-the-knee artery. All had long-segment iliofemoral (TASCII D) occlusions abnormal serum myoglobin ischemic lesions. Clinical outcome...
Abstract The Cordimax stent has proved non-inferior to the Cypher Select durable polymer sirolimus-eluting for primary endpoint of angiographic in-stent late luminal loss and mean diameter stenosis at 9 months. trial was designed compare efficacy safety with Xience V in patients undergoing coronary revascularization. This randomized, multicenter enrolled 3697 treated (2460 patients) (1237 patients). a target-lesion failure (TLF) 1 year composite death or myocardial infarction (MI) 3 years....
The study of hemodynamics regarding thoracic endovascular aortic repair (TEVAR) is helpful to improve the surgical efficacy. Correlations between hemodynamic changes and branch stent extension length interference factors for in situ fenestration TEVAR (ISF-TEVAR) involving left subclavian artery (LSA) were evaluated. This retrospectively analyzed 196 patients with Stanford type B dissection who received laser fenestrated LSA from April 2014 March 2021. Branch main graft was evaluated by...