A5018319496- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Sperm and Testicular Function
- COVID-19 Clinical Research Studies
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- interferon and immune responses
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Long-Term Effects of COVID-19
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Marine and coastal plant biology
- Advanced Optical Network Technologies
- Viral gastroenteritis research and epidemiology
- Advanced Photonic Communication Systems
- Delphi Technique in Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Effects and risks of endocrine disrupting chemicals
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Consumer Attitudes and Food Labeling
Guangzhou University of Chinese Medicine
2023-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021-2024
Wenzhou Medical University
2021-2024
University of Science and Technology of China
2020-2024
Beijing University of Posts and Telecommunications
2024
State Key Laboratory of Information Photonics and Optical Communications
2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2023
Anhui Provincial Center for Disease Control and Prevention
2021-2023
Guangdong Provincial People's Hospital
2020-2022
Tianjin Medical University General Hospital
2021
Coronavirus disease (COVID-19), caused by a novel betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly developed into pandemic since it was first reported in December 2019. Nucleic acid testing is the standard method for diagnosis of viral infections. However, this reportedly low positivity rate. To increase sensitivity COVID-19 diagnoses, we an IgM-IgG combined assay and tested patients with suspected SARS-CoV-2 infection. In total, 56 were enrolled...
Abstract Background The pandemic of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing great loss. Detecting viral RNAs standard approach for SARS-CoV-2 diagnosis with variable success. Currently, studies describing serological diagnostic methods are emerging, while most them just involve detection SARS-CoV-2-specific IgM and IgG by ELISA or “flow immunoassay” limited accuracy. Methods Diagnostic depends on chemiluminescence immunoanalysis (CLIA) detecting IgA,...
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has been confirmed altering viral antigenicity resulting immune escape. To identify crucial mutations that escape humoral response, we evaluated cross-neutralization convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various protein-based pseudoviruses. Three 24 pseudoviruses containing different protein, including...
Despite substantial evidence that visceral obesity is an epidemiological risk factor for hyperuricemia (HUA), studies on the connection between Metabolic Score Visceral Fat (METS-VF) and HUA remain insufficient. This research focused METS-VF's potential role as a HUA. Notably, 8,659 participants from National Health Nutrition Examination Survey (NHANES) 1999 to 2018 were enrolled in this study. Propensity score matching (PSM), multivariate logistic regression analysis, subgroup interaction...
Interleukin (IL)-32 has been recognized as a proinflammatory cytokine that participates in responses to viral infection. However, little is known about how IL-32 induced response infection and the mechanisms of IL-32-mediated antiviral activities. We discovered elevated by hepatitis B virus (HBV) both vitro vivo HBV expression at level transcription post-transcription. Furthermore, microRNA-29b was found be key factor HBV-regulated directly targeting mRNA 3'-untranslated region IL-32....
Abstract The outbreak of the novel coronavirus disease 2019 (COVID-19) infection began in December Wuhan, and rapidly spread to many provinces China. number cases has increased markedly Anhui, but information on clinical characteristics patients is limited. We reported 75 with COVID-19 First Affiliated Hospital USTC from Jan 21 Feb 16, 2020, Hefei, Anhui Province, was confirmed by real-time RT-PCR respiratory nasopharyngeal swab samples. Epidemiological, laboratory data were collected...
Stem Leydig cells (SLCs) play a critical role in the development and maintenance of adult cell (ALC) population. SLCs also are present testis. Their identification, characteristics, regulation testis remain uncertain. Using single-cell RNA-seq, we found that mesenchymal stromal population may be involved ALC regeneration. Upon elimination, fraction begins to proliferate while different differentiate ALCs. Transcriptomic analysis identified five clusters can classified into two major groups...
Acute myocardial infarction (AMI) is a ubiquitous cardiovascular disease ensuing adverse prognosis caused by necrosis. Effective and rapid diagnosis of AMI essential to following treatment in clinical practice while the existed biomarkers have inherent limitations. Consequently, exploration novel needed. Long noncoding RNA (lncRNA) emerges as upcoming adopted use, we aim at investigating diagnostic power lncRNA TTTY15 HULC patients.We measured level 80 patients 36 healthy volunteers...
Background Midazolam is a neurological drug with diverse functions, including sedation, hypnosis, decreased anxiety, anterograde amnesia, brain-mediated muscle relaxation, and anticonvulsant activity. Since it frequently used in children adolescents for extended periods of time, there risk that may affect their pubertal development. Here, we report potential effect the on development Leydig cells (LCs), testosterone (T)-producing testis. Methods Stem LCs (SLCs), isolated from adult rat...
The natural flavonoid compound chrysin has promising anti-tumor effects. In this study, we aimed to investigate the mechanism by which inhibits growth of non-small cell lung cancer (NSCLC). Through in vitro culture and animal models, explored impact on NSCLC cells pro-cancer effects tumor-associated macrophages (TAMs) their mechanisms. We observed that M2-TAMs significantly promoted migration cells, while also markedly activating autophagy level these cells. Chrysin displayed a significant...
The mutants resulted from the ongoing SARS-CoV-2 epidemic have showed resistance to antibody neutralization and vaccine-induced immune response. present study isolated identified two novel neutralizing antibodies (nAbs) convalescent COVID-19 patients. These nAbs (XG81 XG83) were then systemically compared with nine that reconstructed by using published data, revealed that, even though these shared targeting epitopes on spike protein, they different any of nAbs. Compared XG81, XG83 exhibited...
Spermatogenesis is an efficient, complex, and highly organized proliferation differentiation process that relies on multiple factors including testosterone produced by the Leydig cells. Although critical role played in spermatogenesis well recognized, mechanism which it works still not completely understood, partially due to inability specifically precisely monitor testosterone-dependent changes within developing germ Here we present single-cell RNA sequencing data from10,983 adult rat...
The spike trimer of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an effective target for inducing neutralizing antibodies by disease 2019 (COVID-19) vaccines. However, the diversity protein from emerging SASR-CoV-2 variants has become major challenge development a universal vaccine. To investigate immunogenicity proteins various circulating strains including wild type, Delta, and Omicron variants, we produced natural trimers designed three vaccination strategies, that is,...
Background Testosterone plays a critical role in maintaining reproductive functions and well-beings of the males. Adult testicular Leydig cells (LCs) produce testosterone are generated from stem (SLCs) during puberty through adulthood. In addition, macrophages SLC regulatory niche for normal function. Age-related reduction serum contributes to number metabolic quality-of-life changes males, as well age-related immunological functions. How aging may affect function is still unclear. Methods...
Buckwheat is one of the five main allergenic foods (eggs, milk, wheat, buckwheat, and peanuts). Oleosin an important type allergen in some allergic foods. However, although most diagnostic nut seed extracts are defatted, patients with food allergies may have false negative results oleosin vitro. Recently, we found that serum buckwheat responded strongly to 18 kDa protein. Mass spectrometry analysis showed it protein family. We further purified evaluated allergenicity this oleosin-type...
Progenitor cells with ovulation-related tissue repair activity were identified defined markers (LGR5, EPCR, LY6A, and PDGFRA), but their potentials to form steroidogenic not known. This study shows that the can generate progenies different activities.
Background The oxidative balance score (OBS) is a composite indicator that evaluates the between pro-oxidants and antioxidants in one’s diet lifestyle. However, relationship OBS circadian syndrome (CircS) has remained unexplored. This investigation aimed to determine correlation CircS. Methods population-based study examined 7,202 participants from 2005 2018 National Health Nutrition Examination Survey (NHANES), 1,433 of whom had We utilized weighted multivariate logistic regression, trend...
Varicella and herpes zoster are mild symptoms-associated diseases caused by varicella-zoster virus (VZV). They often cause severe complications (disseminated zoster), leading to death when diagnoses treatment delayed. However, most commercial VZV diagnostic tests have low sensitivity, the sensitive unevenly available worldwide. Here, we developed validated a highly kit based on chemiluminescent immunoassay (CLIA) approach. VZV-glycoprotein E (gE) was used develop CLIA approach for detecting...