A5103065776- Ferroptosis and cancer prognosis
- Allergic Rhinitis and Sensitization
- Liver physiology and pathology
- Glioma Diagnosis and Treatment
- Dermatology and Skin Diseases
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Hair Growth and Disorders
- Liver Disease Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Asthma and respiratory diseases
- Viral-associated cancers and disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Autophagy in Disease and Therapy
- Bioinformatics and Genomic Networks
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Platelet Disorders and Treatments
- Food Allergy and Anaphylaxis Research
- Sarcoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- Blood Coagulation and Thrombosis Mechanisms
- Mycobacterium research and diagnosis
- Assisted Reproductive Technology and Twin Pregnancy
Pfizer (China)
2023-2024
Central South University
2012-2023
Third Xiangya Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Tongji Hospital
2019-2020
Huazhong University of Science and Technology
2019-2020
Second Xiangya Hospital of Central South University
2012
Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding mechanisms of glioblastoma at molecular level essential for clinical treatment. In present study, we used bioinformatics analysis to identify potential biomarkers associated prognosis and elucidate underlying mechanisms. The result revealed that 552 genes were differentially expressed between normal tissues based on TCGA, GSE4290, GSE 50161 datasets. Gene Oncology (GO) Kyoto...
Glioblastoma (GBM) is one of the most aggressive and malignant tumor types. Despite treatment advances, GBM pathogenesis still remains largely unknown. MATN1-AS1, an intron-retained long non-coding RNA (lncRNA), has been implicated in development. However, underlying mechanism not identified. This study aimed to examine MATN1-AS1 expression uncover its role GBM.LncRNAs with low levels were selected by analyzing brain glioma-related genes. The relative mRNA level was quantified using RT-qPCR...
Abstract Atopic dermatitis is a chronic inflammatory skin disease with significant impact on the overall wellbeing of patients and their families. Crisaborole ointment, 2%, nonsteroidal phosphodiesterase 4 inhibitor approved for treatment mild‐to‐moderate atopic in multiple countries. However, key pivotal trials, low proportion patient population was Asian, therefore safety efficacy crisaborole Asian remains unclear. CrisADe CLEAR multicenter, randomized, double‐blind, vehicle‐controlled,...
Atopic dermatitis (AD) is a chronic immuno-inflammatory skin disease. Crisaborole ointment, 2%, nonsteroidal phosphodiesterase 4 inhibitor approved for the treatment of mild to moderate AD. This post hoc analysis assesses efficacy and safety crisaborole in Chinese patients aged ≥ 2 years with We evaluated from vehicle-controlled, phase 3 CrisADe CLEAR study. Patients were randomly assigned 2:1 receive or vehicle twice daily, respectively, 28 days. The primary endpoint was percent change...
Glioblastoma (GBM) is the most common primary intracranial malignancy. GBM still exhibits high recurrence and mortality rates even following combined treatment with surgery, radiotherapy chemotherapy, Therefore, identification of novel therapeutic targets urgent. Previous research has shown that nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in cell metabolism closely related to occurrence development many tumor types; yet, little known concerning its relationship GBM....
Glioblastoma (GBM) is the most aggressive primary intracranial tumor in adults. Chemoradiotherapy resistance and recurrence after surgery are main malignant progression factors, leading to a high mortality rate. Therefore, exploration of novel biomarkers molecular mechanisms GBM urgent. Differentially expressed genes (DEGs) were screened TCGA dataset. Homo sapiens ZW10 interacting kinetochore protein (ZWINT) was found be upregulated GBM, which confirmed by immunohistochemical staining tissue...
Abstract The role of Gli-similar 2 (Glis2) in hepatic fibrosis (HF) is controversial. In this study, we focused on the functional and molecular mechanisms involved Glis2-mediated activation stellate cells (HSCs)—a milestone event leading to HF. expression levels Glis2 mRNA protein were significantly decreased liver tissues patients with severe HF mouse fibrotic as well HSCs activated by TGFβ1. Functional studies indicated that upregulated inhibited HSC alleviated BDL-induced mice....
The complete physiological process of hair follicles consists two basic phases,i.e.,embryo follicle morphogenesis and mature cycling.Hair come from ectoderm cells.Besides,the location morphological characteristics have been determined during the embryonic development.Once is formed,it goes into cycling following external stimuli.Hair includes anagen,catagen telogen.Generally,the maintenance are regulated by a series complicated signaling pathways,including Wnt,transforming growth...