A5101762210- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Autophagy in Disease and Therapy
- Head and Neck Cancer Studies
- Renal cell carcinoma treatment
- Soft tissue tumor case studies
- Viral-associated cancers and disorders
- Bioinformatics and Genomic Networks
- Renal and related cancers
- PARP inhibition in cancer therapy
- Corneal Surgery and Treatments
- Single-cell and spatial transcriptomics
- Inflammasome and immune disorders
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- 3D Printing in Biomedical Research
- Inflammatory Bowel Disease
Tongji Hospital
2007-2024
Huazhong University of Science and Technology
2007-2024
Center for Life Sciences
2020-2023
Tsinghua University
2020-2023
Shanxi Academy of Medical Sciences
2020-2023
Hubei Provincial Center for Disease Control and Prevention
2023
German Cancer Research Center
2011-2012
Heidelberg University
2011
University Hospital Heidelberg
2011
Here we investigate the effects of novel transforming growth factor-β receptor I (TGF-βRI) serine/threonine kinase inhibitor LY2109761 on glioblastoma when combined with present clinical standard combination regimen radiotherapy and temozolomide (TMZ). Human GBM U87 (methylated MGMT promoter), T98 (unmethylated endothelial cells (HUVECs) were treated combinations LY2109761, TMZ, radiation. We found that reduced clonogenic survival further enhanced radiation-induced anticlonogenicity. In...
Glioblastoma is a common malignant tumor in the central nervous system with an extremely poor outcome; understanding mechanisms of glioblastoma at molecular level essential for clinical treatment. In present study, we used bioinformatics analysis to identify potential biomarkers associated prognosis and elucidate underlying mechanisms. The result revealed that 552 genes were differentially expressed between normal tissues based on TCGA, GSE4290, GSE 50161 datasets. Gene Oncology (GO) Kyoto...
Pulmonary tuberculosis (PTB) is an infectious disease of major public health problem, China one the PTB high burden counties in word. Hubei provinces having highest notification rate China. This study analyzed temporal and spatial distribution characteristics province for targeted intervention on TB epidemics.The data cases were extracted from National Tuberculosis Information Management System correspond to population 103 Province 2011 2021. The effect control was measured by variation...
// Na Han 1 , Guangyuan Hu Lei Shi Guoxian Long Lin Yang Qingsong Xi Qiuyun Guo Jianhua Wang Zhen Dong and Mengxian Zhang Department of Oncology, Tongji Hospital, Medical College, Huazhong University Science & Technology, Wuhan, China Correspondence to: Zhang, email: zhangmx0904@163.com Keywords: glioblastoma, Notch1, CRISPR/Cas9, radiosensitivity, angiogenesis Received: July 14, 2017 Accepted: September 04, Published: 30, ABSTRACT Broad specific Notch1 inhibitors suppress glioblastoma...
Glioblastoma (GBM) is the most common primary intracranial malignancy. GBM still exhibits high recurrence and mortality rates even following combined treatment with surgery, radiotherapy chemotherapy, Therefore, identification of novel therapeutic targets urgent. Previous research has shown that nicotinamide phosphoribosyltransferase (NAMPT) plays a key role in cell metabolism closely related to occurrence development many tumor types; yet, little known concerning its relationship GBM....
Glioblastoma (GBM) is the most aggressive primary intracranial tumor in adults. Chemoradiotherapy resistance and recurrence after surgery are main malignant progression factors, leading to a high mortality rate. Therefore, exploration of novel biomarkers molecular mechanisms GBM urgent. Differentially expressed genes (DEGs) were screened TCGA dataset. Homo sapiens ZW10 interacting kinetochore protein (ZWINT) was found be upregulated GBM, which confirmed by immunohistochemical staining tissue...
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by multiple genetic and environmental factors. Numerous genes are implicated in the etiology of IBD, but diagnosis IBD challenging. Here, XGBoost, machine learning prediction model, has been used to distinguish from healthy cases following elaborative feature selection. Using combined unsupervised clustering analysis XGBoost selection method, we successfully identified 32-gene signature that can predict occurrence...
To explore the epidemiological characteristics of patients with lymphoepithelial carcinoma (LEC) head and neck prognostic factors.We conducted a retrospective cohort study cases LEC retrieved from Surveillance, Epidemiology End Results database. Kaplan-Meier survival analysis log-rank test were employed to assess overall (OS) cancer-specific (CSS). Univariate multivariate analyses used construct Cox regression models. We established nomograms predict OS CSS among nasopharyngeal LEC, who...
To improve multimodal glioblastoma treatment strategies, it appears useful to integrate a selective inhibitor of the TβR-I kinase, which may be able potentiate radiation responses by increasing apoptosis and cancer-stem-like cell targeting while blocking DNA damage repair, invasion, mesenchymal transition angiogenesis.1
Background: Clear cell renal carcinoma (ccRCC) is the most common malignant tumor of kidney with high mortality. The pathogenesis ccRCC complicated and effective prognostic predictors for clinical practice are still limited. This study aimed to identify significant genes influence in via bioinformatics analysis. Methods: Four gene expression profiles were acquired from Gene Expression Omnibus (GEO) database, including 168 tissues 143 normal tissues. Common differentially expressed (DEGs)...
Paracrine signals play pivotal roles in organ homeostasis. Mesenchymal stromal cells (MSCs) a key role regulating epithelium homeostasis the intestine while their paracrine effects are poorly characterized. Here, we identified prostaglandin E2 (PGE2) secreted by cyclooxygenase (COX)-expressing MSCs as vital factor to maintain intestinal mucosal barrier. We found that MSCs-induced organoid swelling through effect vitro, process due enhanced water adsorption and is mediated COX-PGE2-EP4 axis....
Treatment of gliomas, the most prevalent primary malignant neoplasm central nervous system, is challenging. Arachidonate 5-lipoxygenase activating protein (ALOX5AP) crucial for converting arachidonic acid into leukotrienes and associated with poor prognosis in multiple cancers. Nevertheless, its relationship immune microenvironment gliomas remains incompletely understood.
Objective To investigate the current status of health care-seeking delay and treatment tuberculosis (TB) patients influencing factors in two counties Hubei Province, provide evidence for early detection TB patients. Methods Cross-sectional survey was conducted through face to interview collection patient's medical record information, outpatient inpatient records hospitals univariate analysis logistic regression identify independently associated with delay. Results The median care seeking...
Abstract Objective This study aimed to determine the prognostic factors for disease-specific survival (DSS) of glioblastoma (GBM) and establish a corresponding effective nomogram clinical prediction. Methods was based on Surveillance, Epidemiology, End Results database between 2004 2015 . Kaplan-Meier analysis used evaluate effect various DSS. Lasso regression independent DSS multivariate cox performed correspondingly. Additional restricted cubic spline analyze trend risk (hazard ratio)...