A5101762209- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
Center for Life Sciences
2023
Tsinghua University
2023
Huazhong University of Science and Technology
2014-2019
Tongji Hospital
2019
Glioblastoma (GBM) is one of the most aggressive and malignant tumor types. Despite treatment advances, GBM pathogenesis still remains largely unknown. MATN1-AS1, an intron-retained long non-coding RNA (lncRNA), has been implicated in development. However, underlying mechanism not identified. This study aimed to examine MATN1-AS1 expression uncover its role GBM.LncRNAs with low levels were selected by analyzing brain glioma-related genes. The relative mRNA level was quantified using RT-qPCR...
Radioresistance remains a significant therapeutic obstacle in glioblastoma. Reactive oxygen species (ROS) are associated with multiple cellular functions such as cell proliferation and apoptosis. Nox4 NADPH oxidase is abundantly expressed has proven to be major source of ROS production Here we investigated the effects on GBM tumor invasion, angiogenesis, radiosensitivity. A lentiviral shRNA vector was utilized stably knockdown U87MG U251 glioblastoma cells. measured by flow cytometry using...
As an important part of the stomach, gastric antrum secretes gastrin which can regulate acid secretion and emptying. Although most cell types in are identified, comparison composition gene expression among different species not explored. In this study, we collected epithelial tissues from human, pig, rat mouse for scRNA-seq compared species. pig antral epithelium, identified a novel cluster, is marked by high AQP5, F3, CLCA1 RRAD. We also discovered that porcine epithelium has stronger...