A5100710782- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- RNA regulation and disease
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ultrasound and Hyperthermia Applications
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Caveolin-1 and cellular processes
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Advanced Algorithms and Applications
- Bladder and Urothelial Cancer Treatments
- Biopolymer Synthesis and Applications
- interferon and immune responses
- Fault Detection and Control Systems
- Cancer-related gene regulation
- Machine Fault Diagnosis Techniques
- Mycobacterium research and diagnosis
- Chemical Synthesis and Analysis
- Ubiquitin and proteasome pathways
- Hydrogen's biological and therapeutic effects
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2015-2025
Lanzhou University
2016
Lanzhou University Second Hospital
2016
Sichuan University
2013
West China Hospital of Sichuan University
2013
National Center for Tumor Diseases
2012
University Hospital Heidelberg
2012
Heidelberg University
2012
Tsinghua University
2012
Glioblastoma is highly aggressive and resistant to treatment, making it crucial understand the regulatory mechanisms underlying its invasion. LIN7A, a polar protein, has been implicated in tumor cell migration invasion, but role glioblastoma remains unclear. This study aimed manipulate LIN7A gene expression U87 cells, analyze impact on explore potential through which regulates Lentiviral vectors were used silence selecting most effective vector. transcription, protein localization analyzed...
// Dieter Lemke 1, 2, 3 , Hans-Werner Pledl Markus Zorn 4 Manfred Jugold 5 Ed Green 6 Jonas Blaes 2 Sarah Löw Anne Hertenstein Martina Ott Felix Sahm 7, 8 Ann-Catherine Steffen Weiler Frank Winkler Michael Platten 3, Zhen Dong 9, * Wolfgang Wick 1 German Cancer Consortium (DKTK), Research Center (DKFZ), Heidelberg, Germany Clinical Cooperation Unit Neurooncology, Neurology Clinic and National for Tumor Diseases, University of Central Laboratory Heidelberg Hospital, Core Facility Small...
Glioblastoma (GBM) is one of the most aggressive and malignant tumor types. Despite treatment advances, GBM pathogenesis still remains largely unknown. MATN1-AS1, an intron-retained long non-coding RNA (lncRNA), has been implicated in development. However, underlying mechanism not identified. This study aimed to examine MATN1-AS1 expression uncover its role GBM.LncRNAs with low levels were selected by analyzing brain glioma-related genes. The relative mRNA level was quantified using RT-qPCR...
// Na Han 1 , Guangyuan Hu Lei Shi Guoxian Long Lin Yang Qingsong Xi Qiuyun Guo Jianhua Wang Zhen Dong and Mengxian Zhang Department of Oncology, Tongji Hospital, Medical College, Huazhong University Science & Technology, Wuhan, China Correspondence to: Zhang, email: zhangmx0904@163.com Keywords: glioblastoma, Notch1, CRISPR/Cas9, radiosensitivity, angiogenesis Received: July 14, 2017 Accepted: September 04, Published: 30, ABSTRACT Broad specific Notch1 inhibitors suppress glioblastoma...
Though the overall incidence of gastric cancer was decreasing in developed countries past decades, it is still a serious threat to human health throughout world.The molecular mechanisms underlying development remains unclear.Though accumulating evidences shed light on implications mitochondrial tumor suppressor (MTUS1) carcinogenesis, functional role MTUS1 regulation proliferation and metastasis cell poorly understood.In this study, we showed that level expression relatively low lines...
Background Glioma therapy is challenged by diffuse and invasive growth of glioma. Lysosomal protein transmembrane 5 (LAPTM5) was identified as an invasion inhibitor in vivo screen for invasion-associated genes. The aim this study to decipher the function LAPTM5 glioblastoma its interaction with CD40 receptor which intensively evaluated a target diverse cancers including Methods Knockdown performed different glioma cell lines analyze impact on clonogenicity, invasiveness, sensitivity...
<title>Abstract</title> <bold>Background</bold> Glioblastoma is highly aggressive and resistant to treatment, making it crucial understand the regulatory mechanisms underlying its invasion. LIN7A, a polar protein, has been implicated in tumor cell migration invasion, but role glioblastoma remains unclear. This study aimed manipulate <italic>LIN7A</italic> gene expression U87 cells, analyze impact on explore potential through which LIN7A regulates invasion.<bold>Methods</bold> Lentiviral...
Failure detection and diagnosis system of permanent magnet brushless DC motor (BLDCM) takes an important role in improvement the reliability for BLDCM system. But external dynamic load may affect validity fault location. In this paper, normal models as well five are developed performance under conditions studied simulation. Based on above discussion, effect failure presented. And using Artificial Neural Network (ANN), with is well. Finally simulation results given to verify effectiveness...
Objective To evaluate the efficacy and safety of transurethral bladder tumor prostate resection simultaneously. Methods A total 167 cases bladdr complicated with benign hyperplasia ( BPH) were treated from June 2003 to February 2009 in our hospital. The patients test group (n=108) underwent TURBt TURP at same time, those control received only. There was no significant difference between two groups age, size, location, stage grade, internationl symtoms score (IPSS). Results All operations...
Hashimoto's encephalopathy is a rare brain disease. Its etiology still unknown. In this paper, we reported 15-year-old female patient underwent total thyroidectomy and lymph node dissection, due to multifocal papilliferous carcinoma of the right lobus. Forty-two days after surgery, was treated by ¹³¹I radiotherapy in another hospital begun have headache 48 hours. At last, diagnosed HE on basis all considerations. She recovered from i.v. Immunoglobulin. Till now, has not relapsed for more...
Abstract BACKGROUND Glioma therapy is challenged by the invasive nature of glioma resulting in tumor recurrence and treatment resistance. Lysosomal protein transmembrane 5 (LAPTM5) was identified to inhibit invasion screening for invasion-associated genes glioma. The aim this study decipher function LAPTM5 glioblastoma its interaction with CD40 receptor which shown be highly expressed up 40% glioblastoma. METHODS expression correlated clinical outcome patients. Knockdown performed different...