A5101585388- Asthma and respiratory diseases
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Autoimmune Bullous Skin Diseases
- Plant Pathogens and Fungal Diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Infectious Diseases and Mycology
- Immunodeficiency and Autoimmune Disorders
- Nail Diseases and Treatments
- Reproductive tract infections research
- Parvovirus B19 Infection Studies
- Plant Disease Resistance and Genetics
- Inhalation and Respiratory Drug Delivery
- Dermatological diseases and infestations
- Machine Learning in Healthcare
- Syphilis Diagnosis and Treatment
- Urticaria and Related Conditions
- Plant-Microbe Interactions and Immunity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- bioluminescence and chemiluminescence research
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Invertebrate Immune Response Mechanisms
- Photodynamic Therapy Research Studies
Southern Medical University
2018-2025
Mayo Clinic in Florida
2013-2025
The University of Texas Health Science Center at Houston
2025
Shougang (China)
2024
Anhui Medical University
2019-2024
WinnMed
2020-2022
Oil Crops Research Institute
2022
Henan Institute of Science and Technology
2020
Youngstown State University
2019
Mayo Clinic
2016-2018
Difficulty of asthma ascertainment and its associated methodologic heterogeneity have created significant barriers to care research.We evaluated the validity an existing natural language processing (NLP) algorithm for criteria enable automated chart review using electronic medical records (EMRs).The study was designed as a retrospective birth cohort random sample 500 subjects from 1997-2007 Mayo Birth Cohort who were born at Clinic enrolled in primary pediatric Rochester. Performance...
Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is develop and validate a natural language processing (NLP) algorithm identify that API criteria.This cross-sectional study nested in birth cohort Olmsted County, MN. status ascertained by manual chart review based on served as gold standard. NLP-API was training (n = 87) validated test 427). Criterion...
There is a significant delay between symptom onset and diagnosis of childhood asthma, but the impact this on asthma outcomes has not been well understood. We sought to study association delayed with exacerbations (AEs) in children. Using Mayo Clinic birth cohort, we identified children from electronic health records. defined date as when subjects first met predetermined criteria ascertained by an records-based natural language processing algorithm. Delay (DD) was >30 days (vs timely [TD]...
Childhood asthma often continues into adulthood, but some children experience remission. Utilizing electronic health records (EHRs) to predict prognosis can aid care providers and patients in developing effective prioritized plans. We aimed develop artificial intelligence (AI) models using various clinical variables extracted from EHRs childhood (remission vs no remission) different age groups. developed AI utilizing patients' during the first 6, 9, or 12 years of their lives status at ages...
Abstract Background Early diagnosis and treatment of neurosyphilis is great significance for regression. There no gold standard the neurosyphilis. We did this study to explore factors associated with clinical assess their accuracy Methods retrospectively reviewed 100 cases syphilis patients who underwent lumbar puncture at a major dermatology hospital in Guangzhou, China between April 2013 November 2016. Fifty were clinically diagnosed selected as case group. Control group consisted 50...
antifungal susceptibility profiling of 32 clinical and environmental
Abstract Chromoblastomycosis (CBM), a chronic, granulomatous, suppurative mycosis of the skin and subcutaneous tissue, is caused by several dematiaceous fungi. The formation granulomas, tissue proliferation, fibrosis in response to these pathogenic fungi believed be intricately linked host immunity. To understand this complex interaction, we conducted comprehensive analysis immune cell infiltrates, neutrophil extracellular traps (NETs) formation, mechanism 20 CBM lesion biopsies using...
Abstract Antifungal‐resistant dermatophytes (ARD) infection is a hotspot issue in clinical microbiology and the dermatology field. Trichophyton indotineae as dominant species of dermatophyte with terbinafine‐resistance or multidrug resistance, easy to be missed detection clinically, which brings severe challenges diagnosis treatment. ARD cases have emerged China, it predicts risk transmission among human. Based on existing medical evidence research data, Mycology Group Combination...
Chromoblastomycosis (CBM) is a chronic disease caused by several species of dematiaceous fungi. In this study, regional collection 45 CBM cases was conducted in Guangdong, China, hyper-endemic area CBM. Epidemiology findings indicated that the mean age 61.38 ± 11.20 years, long duration ranged from 3 months to 30 and gender ratio male female 4.6:1. Thirteen (29%) declared underlying diseases. Verrucous form most common clinical manifestation ( n = 19, 42%). Forty-five corresponding strains...
Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue. The most common etiologic agent encountered in Southern China from genus Fonsecaea. Fonsecaea species are often misidentified due to indistinct morphology features; furthermore, recent taxonomy revision was done on fungi genus. Herein, comprehensive evaluation with molecular sequencing data based internal transcribed spacer (ITS) ribosomal DNA regions as targets were implemented 37 clinical isolates...
OBJECTIVE: Whereas few adenomas become cancer, most colorectal cancers arise from adenomas. Telomere length is a recognized biomarker in multiple cancers, and telomere maintenance mechanisms (TMM) are exploited by malignant cells. We sought to determine whether TMM distinguish cancer-associated those that cancer-free. METHODS: Tissues were identified as cancer-adjacent polyp (CAP)—residual adenoma contiguous with cancer—and cancer-free (CFP)—adenomas without malignancy. length, TMM,...
Kerion is a severe type of tinea capitis that difficult to treat and remains public health problem.
Fonsecaea monophora has been the predominant pathogen of chromoblastomycosis in Southern China, but its pathogenic mechanism remains unclear. New models are needed to study this infection. In current study, we examined role melanin on pathogenicity F. Galleria mellonella model using and albino strain. Interestingly, mutant strain displayed higher compared stain restoration could reverse pathogenicity. Histopathology showed that inflammatory nodules were bigger than infected with cells, which...
Abstract Background Endophytic bacteria are considered as symbionts living within plants and influenced by abiotic biotic environments. Pathogen cause stress, which may change physiology of affect the endophytic bacterial communiy. Here, we reveal how in tumorous stem mustard ( Brassica juncea var. tumida) affected plant physiological changes caused Plasmodiophora brassicae using 16S rRNA high-throughput sequencing. Results The results showed that Proteobacteria was dominant group both...
Dematiaceous Fonsecaea monophora is one of the major pathogens chromoblastomycosis. It has been well established that melanization catalyzed by type I polyketide synthase (PKS) in F . Multidomain protein Type PKS encoded six genes, which last enzyme thioesterase (TE) catalyzes cyclization and releases polyketide. Two genes AYO21_03016 ( pks1 ) AYO21_10638 have found both loci same gene arrangement but TE domain truncated at 3’- end. may be key to maintain function To test this hypothesis, we...
Chromoblastomycosis (CMB) is a chronic granulomatous fungal infection that affect the skin and subcutaneous tissues. It clinically problematic due to limited treatment options, low cure rates, high rates of relapse. This underscores necessity for innovative approaches. In this study, potassium iodide (KI) combined with Methylene Blue (MB) mediated antimicrobial photodynamic therapy (PDT) were assessed in Fonsecaea monophora (F. monophora) both vitro vivo. And underlying mechanism contributes...