A5100371821- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cerebrovascular and Carotid Artery Diseases
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Acute Myeloid Leukemia Research
- Prostate Cancer Treatment and Research
- Single-cell and spatial transcriptomics
- Retinoids in leukemia and cellular processes
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Functional Brain Connectivity Studies
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Hematopoietic Stem Cell Transplantation
- Genomics and Chromatin Dynamics
- Airway Management and Intubation Techniques
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Cardiovascular Health and Disease Prevention
- Herpesvirus Infections and Treatments
- Meta-analysis and systematic reviews
Sun Yat-sen Memorial Hospital
2025
Sun Yat-sen University
2025
Nanjing Medical University
2019-2025
Wenzhou Medical University
2020-2025
Capital Medical University
2021-2024
Oregon Health & Science University
2021-2024
Zhongda Hospital Southeast University
2023-2024
Second Affiliated Hospital of Nanchang University
2020-2024
Nanchang University
2020-2024
Beijing Tian Tan Hospital
2021-2024
Gene tree topologies have proven a powerful data source for various tasks, including species inference and delimitation. Consequently, methods computing probabilities of gene trees within been developed widely used in probabilistic frameworks. All these assume an underlying multispecies coalescent model. However, when reticulate evolutionary events such as hybridization occur, are inadequate, they do not account events. Methods that both deep coalescence the probability topology currently...
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung (NSCLC) accounts for over 80% cases. The RNA binding protein, QKI, belongs to STAR family plays tumor-suppressive functions in NSCLC. QKI-5 a major isoform QKIs predominantly expressed However, underlying mechanisms NSCLC progression remain unclear. We found that regulated microRNA (miRNA), miR-196b-5p, its expression was significantly up-regulated tissues. Up-regulated miR-196b-5p promotes migration,...
Abstract Neovascular age-related macular degeneration and diabetic retinopathy are prevalent causes of vision loss requiring frequent intravitreous injections VEGF-neutralizing proteins, under-treatment is common problematic. Here we report incorporation sunitinib, a tyrosine kinase inhibitor that blocks VEGF receptors, into non-inflammatory biodegradable polymer to generate sunitinib microparticles specially formulated self-aggregate depot. A single injection potently suppresses choroidal...
Abstract: Automated electrocardiogram (ECG) diagnosis could be a useful aid for clinical use. We applied deep learning method to build system automated detection and classification of ECG signals. first trained convolutional neural network (CNN) detect cardiovascular disease in signals using training data set 259,789 collected from the cardiac function rooms tertiary care hospital. The CNN was validated an independent test 18,018 labels used covered >90% diagnoses. grouped ECGs into 18...
Abstract The von Hippel-Lindau (VHL) is deficient in ∼70% of clear-cell renal cell carcinomas (ccRCC), which contributes to the carcinogenesis and drug resistance ccRCC. Here we show that VHL-deficient ccRCC cells present enhanced cytotoxicity anthracyclines a hypoxia-inducible factor-independent manner. By subtractive proteomic analysis coupling with RNAi or overexpression verification, aldehyde dehydrogenase 2 (ALDH2) found be transcriptionally regulated by VHL cells. Furthermore,...
Hinokitiol, alternatively known as β-thujaplicin, is a tropolone-associated natural compound with antimicrobial, anti-inflammatory and antitumor activity. Breast cancer stem/progenitor cells (BCSCs) are subpopulation of breast associated tumor initiation, chemoresistance metastatic behavior, may be enriched by mammosphere cultivation. Previous studies have demonstrated that BCSCs exhibit vasculogenic mimicry (VM) activity via the epidermal growth factor receptor (EGFR) signaling pathway. The...
Osteosarcoma is the most frequent malignant bone cancer in teenagers. In this study, cell division cycle 6 (Cdc6) was upregulated tumor tissues from patients with osteosarcoma according to results of RNA sequencing. Cdc6 has been considered as a candidate prognostic marker, which associated apoptosis and cycle. However, mechanisms by regulates arrest remain unclear.Firstly, 3 pairs adjacent normal were subjected addition, levels 30 patients' lines detected western blotting RT-qPCR. Moreover,...
Sepsis-induced myocardial dysfunction (SIMD) is ubiquitous in septic shock patients and associated with high morbidity mortality rates. Heat protein 22 (Hsp22), which belongs to the small HSP family of proteins, involved several biological functions. However, function Hsp22 lipopolysaccharide (LPS)-induced injury not yet established. This study was aimed at investigating underlying mechanistic aspects induced by LPS. In this study, following random assignment male C57BL/6 mice into control,...
Purpose: The study aimed to investigate the relationship between average daily steps (ADS) and optic disc angioflow vessel density (VD) in patients with primary open angle glaucoma (POAG). Materials Methods: This is a cross-sectional study. Forty-one POAG (74 eyes) were recruited from Wenzhou Glaucoma Progression Study (WGPS) who divided into two groups based on international physical activity guidelines: 21 subjects (38 ADS>10,000 group 20 (36 ADS≤10,000 group. ADS was monitored using...