A5034471208- Genomics and Phylogenetic Studies
- Hematopoietic Stem Cell Transplantation
- Bacteriophages and microbial interactions
- Dietary Effects on Health
- Nutrition and Health in Aging
- Plant Virus Research Studies
- Renal Transplantation Outcomes and Treatments
- Vibrio bacteria research studies
- Platelet Disorders and Treatments
Oregon Health & Science University
2024
Massachusetts Institute of Technology
2021
Wild phage evolution Bacteria possess a diversity of highly specific defense mechanisms that evolve rapidly and account for large proportion bacterial genomes. These dynamics must be understood if therapy is to seriously considered clinical use. Hussain et al . studied set nearly clonal wild-caught Vibrio lentus hosts their found the segregated into two groups infected by different viruses (see Perspective Meaden Fineran). Puzzlingly, both host have same surface receptors. This apparent...
Abstract Although it is generally accepted that viruses (phages) drive bacterial evolution, how these dynamics play out in the wild remains poorly understood. Here we show arms race between phages and their hosts mediated by large highly diverse mobile genetic elements. These phage-defense elements display exceedingly fast evolutionary turnover, resulting differential phage susceptibility among clonal strains while receptors remain invariant. Protection afforded multiple cumulative, a single...