A5101552195- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- Reconstructive Surgery and Microvascular Techniques
- Sarcoma Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Advanced Photocatalysis Techniques
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Neurogenesis and neuroplasticity mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Shoulder Injury and Treatment
- Pelvic and Acetabular Injuries
- Management of metastatic bone disease
- Nanoparticle-Based Drug Delivery
- Lung Cancer Treatments and Mutations
- 3D Printing in Biomedical Research
- Orthopedic Surgery and Rehabilitation
- Mesenchymal stem cell research
- Proteoglycans and glycosaminoglycans research
- Liver physiology and pathology
Soochow University
2014-2024
First Affiliated Hospital of Soochow University
2016-2024
Shanghai Jiao Tong University
2004-2023
International Peace Maternity & Child Health Hospital
2019-2023
Shanghai Pulmonary Hospital
2023
Tongji University
2023
Cancer Institute (WIA)
2023
Women's Hospital, School of Medicine, Zhejiang University
2023
The University of Texas Southwestern Medical Center
2023
Shanghai Ninth People's Hospital
2019-2022
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate resulting protection chondrocytes attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized M1/M2 subtypes then administered with different concentrations Kin. polarization transitions evaluated quantitative real-time polymerase chain reaction (qRT-PCR), confocal observation flow cytometry analysis. mechanism Kin repolarizing M1 by Western blot. Further,...
Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal diseases among elderly population. In this study, macrophage-derived exosomes were isolated and identified. Exosomes subjected to microRNA (miRNA) sequencing bioinformatic analysis, differentially expressed miRNAs verified. miR-26b-5p target genes confirmed through target-site mutation combined with a dual-luciferase reporter assay. The effects on macrophage polarization chondrocyte hypertrophy assessed in vitro. agomir...
Reduced graphene oxide (RGO)-porphyrin (TPP) nanohybrids (RGO-TPP 1 and RGO-TPP 2) were prepared by two synthetic routes that involve functionalization of the RGO using diazonium salts. The microscopic structures, morphology, photophysical properties nonlinear optical performance resultant investigated. covalent bonding porphyrin-functionalized-RGO nanohybrid materials was confirmed Fourier transform infrared spectroscopy, Raman X-ray photoelectron transmission electron microscopy,...
Accumulating evidence suggests that activation of proinflammatory M1-type macrophages in the synovium plays a vital role progression osteoarthritis (OA). Redundant nitric oxide (NO) and hydrogen peroxide (H2O2) are key factors drive to polarize M1 type. Herein, modified zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (NPs) have been synthesized. By regulating intracellular gases reprogramming metabolism phenotype, NPs transformed macrophage polarization from anti-inflammatory M2...
Large bone defects face a high risk of pathogen exposure due to open wounds, which leads infection rates and delayed union. To promote successful repair infectious defects, fabrication scaffold with dual functions osteo-induction bacterial inhibition is required. This study describes creation an engineered progenitor cell line (C3H10T1/2) capable doxycycline (DOX)-mediated release morphogenetic protein-2 (BMP2). Three-dimensional bioprinting technology enabled scaffolds, comprising...
Accumulating evidence suggests that osteoclastogenesis and angiogenesis in subchondral bone are critical destructive factors the initiation progression of osteoarthritis (OA). Herein, methoxypolyethylene glycol amine (mPEG-NH2) modified polydopamine nanoparticles (PDA-PEG NPs) were synthesized for treating early OA. The cytotoxicity reactive oxygen species (ROS) scavenging ability PDA-PEG NPs evaluated. effects on osteoclast differentiation vessel formation then Further, administrated to...
In this work, a new multifunctional nanoplatform (Fe3O4@mSiO2-FA-CuS-PEG nanocomposite) for magnetic resonance imaging (MRI) and targeted chemo-photothermal therapy, was firstly fabricated on the basis of mesoporous silica nanoparticles (Fe3O4@mSiO2), which folic acid (FA) grafted as targeting reagent, CuS nanocrystals were attached photothermal agent, polyethylene glycol (PEG) coupled to improve biocompatibility. The characterization results demonstrated that Fe3O4@mSiO2-FA-CuS-PEG...
Multifunctional nanomaterials open an avenue for the integration of cancer treatment and diagnosis, trending towards clinical application nanomedicines in future. Herein, we synthesized biocompatible CuCo2S4 nanocrystals (NCs) via a simple reflux method unitized them as new theranostic platform, where intense near-infrared (NIR) absorption offers NCs perfect photothermal performance photoacoustic (PA) imaging ability; magnetic characteristic Co allows to serve enhanced resonance (MR)...
Abstract Increasing evidence indicates that osteoarthritis (OA) is a musculoskeletal disease affecting the whole joint, including both cartilage and subchondral bone. Reactive oxygen species (ROS) have been demonstrated to be one of important destructive factors during early‐stage OA development. The objective this study was investigate isorhamnetin (Iso) treatment on osteoclast formation chondrocyte protection attenuate by modulating ROS. Receptor activator nuclear factor‐kappa B ligand...
Background: Cerium oxide nanoparticles (CeO 2 NPs) are potent scavengers of cellular reactive oxygen species (ROS). Their antioxidant properties make CeO NPs promising therapeutic agents for bone diseases and tissue engineering. However, the effects on intracellular ROS production in osteoclasts (OCs) still unclear. Numerous studies have reported that essential osteoclastogenesis. The aim this study was to explore osteoclast differentiation potential underlying mechanisms. Methods:...
A dual-functional 3D printed scaffold with both anti-infection and bone homeostasis-regulating properties for infected defect treatment.
Osteoarthritis (OA) management remains challenging because of its intricate pathogenesis. Intra-articular injections drugs, such as glucocorticoids and hyaluronic acid (HA), have certain limitations, including the risk joint infection, pain, swelling. Hydrogel-based therapeutic strategies attracted considerable attention their enormous potential. Herein, a supramolecular nanofiber hydrogel is developed using dexamethasone sodium phosphate (DexP) vector to deliver lentivirus-encoding...
Subchondral bone marrow lesions (BMLs) are common magnetic resonance imaging (MRI) features in joints affected by osteoarthritis (OA), however, their clinical impacts and mechanisms remain controversial. Thus, we aimed to investigate subchondral BMLs knee OA patients who underwent total arthroplasty (TKA), then evaluate the associations of osteoclastogenesis nerve growth with symptoms.Total 70 primary symptomatic were involved, separated into three groups based on MRI (without group, n =...
Fe<sub>3</sub>O<sub>4</sub>@chitosan nanospheres were fabricated by a facile one-step method for MRI and fluorescence imaging guided chemo-photothermal combinational cancer therapy.
Abstract Metastasis and chemotherapy resistance are the key factors affecting effectiveness of osteosarcoma (OS) treatments. CXCR1 overexpression is found to be closely related anoikis in OS cell subtypes with high metastasis potential. Further study demonstrates that highly expressed on circulating tumor (CTC)‐derived cells cancer stem characteristics. Then, a targeting peptide designed synthesized competitively inhibit IL‐8/CXCR1 pathway improve cisplatin sensitivity CTCs....
In this study, a multifunctional nano-drug (PTX-loaded Cys-Fe3O4/CuS@BSA nanocomposite), which performs well in hydrophobic drug delivery, magnetic resonance imaging (MRI) and chemo-photothermal combination therapy, has been successfully synthesized via facile method with several biocompatible agents. The characterization verified that our as-obtained nanocarrier preferable average diameter of about 300 nm for cancer shows great MRI ability magnetism performance, exhibits favorable vitro...
To evaluate the interbody fusion efficacy and biocompatibility of a graft-free cage made polyetheretherketone/calcium silicate composite/porous tantalum (PEEK/CS/pTa cage) compared with PEEK/CS an autogenous bone graft in goat model. PEEK/CS/pTa cages were prepared through injection-moulding method. The composites porous characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron (XPS), diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive (EDS)...