A5087856092- Pharmacological Receptor Mechanisms and Effects
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neurological disorders and treatments
- Pain Mechanisms and Treatments
- Treatment of Major Depression
- Axial and Atropisomeric Chirality Synthesis
- Innovations in Medical Education
- Ion channel regulation and function
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemical synthesis and alkaloids
- Glycogen Storage Diseases and Myoclonus
- Marine Sponges and Natural Products
- Epilepsy research and treatment
- Computational Drug Discovery Methods
- Innovative Teaching Methods
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer therapeutics and mechanisms
- Traumatic Brain Injury Research
University of Hawaii at Hilo
2024
University of the Pacific
2024
West Virginia University
2011-2020
Touro University California
2014-2020
Chicago State University
2012
West Virginia University Hospitals
2012
University of South Florida
2012
Florida College
2012
University of Mississippi
2005-2011
University of Oklahoma Health Sciences Center
2000-2011
Haloperidol exhibits a high affinity for subclass of σ-"opiate" binding sites which have unique anatomic distribution and drug selectivity pattern. These differ from phencyclidine-sensitive σ-receptors are found in many brain areas involved the control movement. 1,3-Di-o-tolylguanidine (DTG), highly selective ligand haloperidol-sensitive σ-receptor, produced marked dystonia rats after micro injection into red nucleus, motor area rich this receptor. another σ-ligand [(+)-SKF 10,047] similar...
σ-1 receptor (S1R) radioligands have the potential to detect and monitor various neurological diseases. Herein we report synthesis, radiofluorination, evaluation of a new S1R ligand 6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ([(18)F]FTC-146, [(18)F]13). [(18)F]13 was synthesized by nucleophilic fluorination, affording product with >99% radiochemical purity (RCP) specific activity (SA) 2.6 ± 1.2 Ci/μmol (n = 13) at end synthesis (EOS). Positron emission tomography...
Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition binding NMDA receptors, dextromethorphan binds sigma-1 (σ1) which are believed be protein targets for potential new class medications. The purpose this study was determine whether elicits antidepressant-like effects and involvement σ1 receptors...
To determine if Grit-S scores correlate with academic success in a doctor of pharmacy (PharmD) program, as well the pursuit and attainment postgraduate (residency or fellowship) training.