A5012803832- Acute Ischemic Stroke Management
- Phosphodiesterase function and regulation
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Cardiovascular Health and Disease Prevention
- Salivary Gland Disorders and Functions
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Renal and Vascular Pathologies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Abdominal vascular conditions and treatments
- Piperaceae Chemical and Biological Studies
- Resilience and Mental Health
- Photoreceptor and optogenetics research
- Autism Spectrum Disorder Research
- Extracellular vesicles in disease
- Neurological Disorders and Treatments
- Amino Acid Enzymes and Metabolism
Nanjing Medical University
2011-2024
Changzhou No.2 People's Hospital
2011-2024
Xian Yang Central Hospital
2016
Second Affiliated Hospital of Nanjing Medical University
2013
Wenzhou Medical University
2013
GluN2A and GluN2B are the major subunits of functional NMDA receptors (NMDAR). Previous studies have suggested that may differentially mediate NMDAR function at synaptic extrasynaptic locations play opposing roles in excitotoxicity, such as neurodegeneration triggered by ischemic stroke brain injury. By using pharmacological molecular approaches to suppress or enhance cultured cortical neurons, we examined NMDAR-mediated, bidirectional regulation prosurvival signaling (i.e. cAMP response...
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative illness, characterized by memory loss and cognitive decline, accounting for 60– 80% of dementia cases. AD senile plaques made up amyloid β (Aβ) protein, intracellular neurofibrillary tangles caused hyperphosphorylation tau protein linked with microtubules, neuronal loss. Currently, therapeutic treatments nanotechnological developments are effective in treating symptoms AD, but a cure illness has not yet been found....
To investigate the psychological distress experienced by healthcare workers (HCWs) at a tertiary hospital in Changzhou, China, outside Wuhan, during early stage of COVID-19 and evaluate moderating effects resilience social support on relationship between stress distress.The study was conducted February 10 15, 2020, non-probabilistic way. The survey included questions regarding risk exposure, sociodemographics, perceived [10-item Perceived Stress Scale (PSS-10)], Connor-Davidson Psychological...
Abstract Beta amyloid peptides (Aβ) are known risk factors involved in cognitive impairment, neuroinflammatory and apoptotic processes Alzheimer’s disease (AD). Phosphodiesterase 2 (PDE2) inhibitors increase the intracellular cAMP and/or cGMP activities, which may ameliorate deficits associated with AD. However, it remains unclear whether PDE2 mediated neuroapoptotic events, as well performance AD related to cAMP/cGMP-dependent pathways. The present study investigated how selective inhibitor...
Abstract Background Non-stenotic carotid plaque is considered an important etiology of embolic stroke undetermined source (ESUS). However, only a few previous studies included negative control group, and the characteristics non-stenotic in ESUS have yet to be investigated. The objective this study explore clinical correlation between ESUS. Methods This single-center, retrospective cross-sectional observational conducted compare differences information among ESUS, CE, large-artery...
Abstract Background Few studies have investigated the influence of white matter lesions (WMLs) on prognosis acute cardioembolic stroke (CES). We aimed to explore role WMLs in predicting 3-month CES without reperfusion therapy. Methods A number 251 patients therapy at a single center were retrospectively recruited. The severity was evaluated by Fazekas scale and divided into mild group (188 cases, ≤ 2 points) moderate severe (63 ≥ 3 accordingly. General data clinical features two groups...
This study was to explore the role of pre-existing small vessel disease (SVD) on 3-month outcomes acute cardioembolic stroke (CES) patients.Data 189 consecutive CES patients at a single center were retrospectively enrolled. SVD imaging markers lacunes, white matter hyperintensities (WMH) and enlarged perivascular spaces (EPVS) evaluated their total burden score (0-3 points) calculated. Patients divided into good functional outcome group (modified Rankin scale, mRS ≤ 2) poor (mRS ≥ 3) 3...
This study was to evaluate the relationship of atherosclerotic renal artery stenosis (ARAS) with extracranial carotid arteries atherosclerosis (ECAS) and intracranial cerebral (ICAS) in ischemic stroke (IS) patients.This a prospective cohort analysis consecutive patients IS who had not history (RAS). Abdominal aortography performed screen for RAS after cerebrovascular diagnostic procedure. Multivariate logistic regression investigate association clinical variables significant ARAS (≥...
PDE2 is the most prevalent of all PDEs expressed in hippocampus and frontal cortex, regions involved cognition especially vulnerable to damage at early stages AD. Studies suggest that beta‐amyloid 1‐42 (Abeta 1‐42) has a detrimental effect on memory performance induces initial major symptom Alzheimer's disease (AD) via inhibition both cAMP/cGMP‐dependent pathway. Microinfusion Abeta animal models leads deposition, inflammation, neuroapoptosis impairment. However, whether phosphodiesterase...
Abstract Background Few studies have investigated the influence of white matter lesions (WMLs) on prognosis acute cardioembolic stroke (CES). We aimed to explore role WMLs in predicting 3-month CES without reperfusion therapy. Methods A number 251 patients therapy at a single center were retrospectively recruited. The severity was evaluated by Fazekas scale and divided into mild group (188 cases, ≤ 2 points) moderate severe (63 ≥ 3 accordingly. General data clinical features two groups...