A5075460990- Effects and risks of endocrine disrupting chemicals
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Protein Kinase Regulation and GTPase Signaling
- Parathyroid Disorders and Treatments
- Virus-based gene therapy research
- Kidney Stones and Urolithiasis Treatments
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- Neuroendocrine Tumor Research Advances
- Viral Infectious Diseases and Gene Expression in Insects
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Integrated Circuits and Semiconductor Failure Analysis
- Pediatric Urology and Nephrology Studies
- Lung Cancer Research Studies
- Liver Disease Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Health, Environment, Cognitive Aging
Tongji Hospital
2023-2024
Tongji University
2023-2024
Nanjing Medical University
2020-2023
Jiangsu Province Hospital
2022
Intrahepatic cholangiocarcinoma (iCCA) is a lethal hepatobiliary malignancy that arises from the epithelial cells of intrahepatic bile ducts, accounting for approximately 10% (CCA). According to 2019 World Health Organization (WHO) classification tumors digestive system, iCCA divided into small-duct type (SD-type) and large-duct (LD-type). However, it remains unknown which molecular events contribute disparity. To explore proteomic characteristics iCCA, we used an isobaric tag relative...
Abstract Background The present study aimed to evaluate the elimination of three common pollutants (dimethoate, benzo(a)pyrene (BaP) and bisphenol A (BPA) by different physical exercises assess possible factors which could affect elimination. Methods total 200 individuals who chose kinds in accordance their own wish were recruited. levels urinary measured using β-glucuronidase hydrolysis followed a high-performance liquid chromatography tandem mass spectrometry-based method. Results Totally,...
Abstract Background The objective of this study was to detect the urinary levels dimethoate, benzo(a) pyrene (BaP), and bisphenol A (BPA) in first-year Hohai University students with different geographic origins. Methods First-morning urine samples were collected from 540 healthy freshmen aged 17 19 years. Chemical measured using β-glucuronidase hydrolysis followed by a high-performance liquid chromatography-tandem mass spectrometry-based method. Geometric means (GMs) these three chemicals...
The roles of Rho GTPases in various types cancer have been extensively studied, but the research guanine nucleotide exchange factors (GEFs) is not comprehensive. factor 6 (ARHGEF6) an important member GEFs family involved cytoskeletal rearrangement, and it has investigated acute myeloid leukemia (AML). Our showed that expression ARHGEF6 was mainly higher AML cell lines, meanwhile, highest samples from patients with compared to other types. High associated a good prognosis. low cases...
Abstract Background Currently, there is no predictive model for the efficacy of autologous CD19 chimeric antigen receptor T-cell therapy (CAR-T) in relapsed or refractory diffuse large B-cell lymphoma (r/r DLBCL). This study aims to construct a comprehensive that takes into account numerous influencing factors predict CAR-T therapy. Methods A total 80 r/r DLBCL patients receiving from two centers were included study. Multivariable logistic regression analysis was constructed using data...
Abstract Background Parenteral nutrition (PN)-associated liver disease (PNALD) is a common and life-threatening complication in patients receiving PN. However, its definitive etiology not yet clear. Therefore, performed proteomic analyses of human tissue to explore the same. Methods Liver was derived compared across selected with (n = 3) /without 4) PNALD via isobaric Tag for Relative Absolute Quantitation (iTRAQ)-based quantitative proteomics. Bioinformatics analysis using Gene Ontology...
Objective: To compare the clinical features of multiple endocrine adenoma type 1 (MEN-1) associated pancreatic neuroendocrine neoplasms (pNENs) as well sporadic pNENs. Methods: The data 28 pNENs patients and 10 MEN-1-related admitted to First Affiliated Hospital Nanjing Medical University from January 2010 June 2021 were collected. Meanwhile, by searching PubMed database reviewing 20 foreign with which reported at same time.Compare analyze similarities differences between MEN1-associated in...
Abstract Background : The objective of this study was to detect the urinary level dimethoate, benzo(a)pyrene (BaP), and bisphenol A (BPA) in first-year Hohai University students different geographic origins. Methods First-morning urine samples were collected from 540 healthy freshmen aged 17 19. Toxin levels measured using β-glucuronidase hydrolysis followed by a high-performance liquid chromatography-tandem mass spectrometry-based method. Geometric means (GM) are presented BMI (Body Mass...