A5100636526- Pancreatic and Hepatic Oncology Research
- Cancer therapeutics and mechanisms
- Ferroptosis and cancer prognosis
- Infection Control and Ventilation
- Phytochemicals and Antioxidant Activities
- Building Energy and Comfort Optimization
- Radiomics and Machine Learning in Medical Imaging
- Wind and Air Flow Studies
- Testicular diseases and treatments
- RNA and protein synthesis mechanisms
- MRI in cancer diagnosis
- RNA regulation and disease
- Peptidase Inhibition and Analysis
- Bone and Dental Protein Studies
- Neuroendocrine Tumor Research Advances
- 14-3-3 protein interactions
- Sodium Intake and Health
- Urinary Bladder and Prostate Research
- Protein Tyrosine Phosphatases
- Renal and Vascular Pathologies
- Tea Polyphenols and Effects
- Peripheral Artery Disease Management
- Cancer Mechanisms and Therapy
- Cardiac Imaging and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
North China University of Science and Technology
2025
China Pharmaceutical University
2021-2024
Beijing Chao-Yang Hospital
2022-2024
Capital Medical University
2022-2024
Ningxia Medical University
2023-2024
Guangdong Medical College
2022-2024
Guangxi Medical University
2024
Peking University
2024
State Key Laboratory of Natural Medicine
2021-2023
Wuhan University
2020-2023
Yellowhorn (Xanthoceras sorbifolium Bunge) is a unique oilseed tree in China with high edible and medicinal value. However, the application potential of yellowhorn has not been adequately explored. In this study, widely targeted metabolomics (HPLC-MS/MS GC-MS) network pharmacology were applied to investigate nutritional leaves flowers. The results suggested that leaf contains 948 non-volatile metabolites 638 volatile metabolites, while flower 976 636, respectively. A metabolite analysis...
At present, there is a lack of research on the correlation between cumFPG and digestive malignancies, previous cohort studies have not considered competitive risk death which may overestimate impact related factors. To explore malignant tumors system. In this study, 53,747 participants who had undergone 3 consecutive physical examinations since 2006 were collected. Finally, total included in study. According to grouping method studies, was divided into 4 groups according quartile. Cox...
In recent years, morbidity and mortality of prostate cancer (PCa) have increased dramatically, while mechanistic understanding its onset progression remains unmet. LncRNA SNHG3 has been proved to stimulate malignant multiple cancers, whereas functional mechanism in PCa needs be deciphered. this study, our analysis the TCGA database revealed high expression tissue. Further starBase, TargetScan, mirDIP databases identified SNHG3/miR-152-3p/SLC7A11 regulatory axis. FISH was conducted assess...
Objectives The incidence of bystander cardiopulmonary resuscitation (CPR) is low in China. CPR training could improve public attitudes and willingness, but at present, the after online are unclear. This study investigated individual towards CPR, willingness to perform it emergencies along with main obstacles overall effects training. Design Questionnaires were distributed investigate performing CPR. Setting accessible course ‘First Aid’. Participants 1888 students who attended Aid’ from...
Epidermal growth factor receptor (EGFR)-activating mutation is an important oncogenic driver of nonsmall cell lung cancer (NSCLC) patients. Osimertinib has been the first-line treatment for EGFR-mutated NSCLC. However, tertiary C797S leads to resistance by blocking covalent binding Cys797 Osimertinib. To date, there are no approved inhibitors resistance. Herein, we identified a novel lead compound S8 targeting EGFRL858R/T790M/C797S structure-based virtual screening and synthesized series...
Abstract In China, according to the ‘Technical Operating Procedures for Blood Stations (2019 Edition),’ blood stations are authorized utilize Chemiluminescence Immunoassay (CLIA) detect pathogen markers linked with transfusion-transmissible infections. However, currently, there is no approved CLIA reagent screening of blood-borne diseases in specifically detection Hepatitis B surface antigen. The objective this research project conduct a comprehensive evaluation performance Wantai...
Receptor Expression-Enhancing Protein 3 (REEP3) serves as a pivotal enzyme crucial for endoplasmic reticulum (ER) clearance during mitosis and is implicated in the advancement of diverse malignancies. Nonetheless, biological role mechanisms REEP3 pancreatic cancer patients, along with its interplay immune infiltration, remain inadequately elucidated. In this study, we initially analyzed differential expression between tissues normal pancreas using Cancer Genome Atlas (TCGA), GTEx Gene...
Abstract Prostate cancer (PCa) is one of the most prevalent cancers in men worldwide, and hormonal therapy plays a key role treatment PCa. However, drug resistance makes it urgent necessary to identify novel targets for PCa treatment. Herein, dual-specificity tyrosine phosphorylation-regulated kinase 2 (DYRK2) found confirmed be highly expressed tissues cells, knock-down DYRK2 remarkably reduces burden vitro vivo. On base acting as promising target, we further discover selective inhibitor...
ST-elevated myocardial infarction (STEMI) is the leading cause of mortality worldwide. The rate heart attacks has decreased due to various preventive factors and development early diagnostic resuscitation measures, but long-term prognosis remains poor. present study aimed identify novel serum biomarkers in STEMI patients explored a possible new mechanism from an immune molecular angle with bioinformatics analysis.Gene expression profiles were obtained Gene Expression Omnibus (GEO) database....
Abstract Background Cysteine‐rich protein 2 (CSRP2) is discovered as oncogene. The study aims to investigate the clinical significance and potential mechanism of CSRP2 in head neck squamous cell carcinoma (HNSCC). Methods expression was explored by immunohistochemistry tissue microarrays Western blotting HNSCC. effect on cancer stemness epithelial‐to‐mesenchymal transition (EMT) HNSCC cells investigated sphere formation, wound healing, transwell assays. vitro vivo experiments revealed that...
The objective of this study was to screen angiotensin converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory peptides from simulated gastrointestinal digestion C-phycocyanin using in silico methods.The molecular interaction complex stability C-phycocyanin-derived with two receptors (ACE DPP-IV) were studied.After digestion, 32 unreported screened by comparing BIOPEP-UWM AHTPDB database, none them exhibited toxicity the body based on ADMET predicted results.Moreover, four...
Nowadays, the simultaneous inhibition of two or more pathways plays an increasingly important role in cancer treatment due to complex and diverse pathogenesis cancer, combination cyclin-dependent kinase 6 (CDK6) inhibitor PIM1 was found generate synergistic effects acute myeloid leukemia (AML) treatment. Therefore, we discovered a novel lead 1 targeting CDK6/PIM1 via pharmacophore-based structure-based virtual screening, synthesized five different series new derivates, obtained potent...
Bladder cancer (BLCA) is one of the most prevalent urinary system malignancies, with high mortality and recurrence. The present study aimed to identify potential tumor antigens for mRNA vaccines in BLCA patient subtypes suitable different immunotherapy. Gene expression profiles, mutation data, methylation corresponding clinical information were obtained from Cancer Genome Atlas (TCGA), Expression Omnibus (GEO), ArrayExpress databases. Immunohistochemical staining microarrays was performed...
Abstract Background There are few studies on cryptorchidism in adults, and its treatment is still controversial. Methods To summarize the surgical strategy clinical efficacy of laparoscopic orchidopexy for 37 adult patients were retrospectively analyzed between September 2017 February 2022. All underwent orchidopexy, whom 33 inguinal hernia repair without tension. The intraoperative procedures techniques recorded detail. Preoperative examination regular postoperative review color Doppler...
Objective: To assess the effectiveness and safety of an IVUS-guided rotational atherectomy (RA) percutaneous coronary intervention (PCI) in chronic renal patients with complex calcification who are at risk for contrast-related acute kidney injury (AKI). Methods: From October 2018 to 2021, 48 disease were receiving PCI RA General Hospital NingXia Medical University informed data collection this research. They randomly assigned group Standard group, which did not use IVUS. According a clinical...