A5102002240- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ginseng Biological Effects and Applications
- Cancer Genomics and Diagnostics
- Signaling Pathways in Disease
- Cancer Research and Treatments
- Microtubule and mitosis dynamics
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Inflammation biomarkers and pathways
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Traditional Chinese Medicine Analysis
- Microbial Applications in Construction Materials
- Helicobacter pylori-related gastroenterology studies
- Sepsis Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Protein Degradation and Inhibitors
- Cardiac Arrhythmias and Treatments
UPMC Hillman Cancer Center
2025
University of Pittsburgh
2025
South China Agricultural University
2023
Second Affiliated Hospital of Jilin University
2019-2022
Nanjing Medical University
2017-2021
Second Hospital of Shandong University
2021
Jiangsu Province Hospital
2017-2021
Shanghai Jiao Tong University
2019
The First People’s Hospital of Lianyungang
2019
Shanghai Sixth People's Hospital
2019
Immune checkpoint inhibitors (ICIs), such as anti-PD-1 and anti-CTLA-4, have significantly advanced melanoma treatment by reactivating the immune system to target cancer cells. However, a substantial portion of patients do not respond or develop resistance, highlighting need for more effective predictive biomarkers. Dysregulation transcriptional programs has been implicated in progression evasion, with transcription factors (TFs) playing crucial role. In this study, we investigated gene...
Litter size is an important indicator to measure the reproductive performance of goats, which affected by function animals. The hypothalamus, as regulatory center endocrine system, plays role in reproduction female Here, we performed high-throughput RNA sequencing using hypothalamic tissue from high-fecundity and low-fecundity Leizhou goats explore critical functional genes associated with litter size. Differentially expressed mRNA, lncRNA, circRNAs were screened DESeq enriched, then...
Ginsenoside Rb1 (GS‑Rb1) is one of the most important active pharmacological extracts traditional Chinese medicine, ginseng, and there extensive evidence its cardioprotective properties. However, microRNA (miR) targets GS‑Rb1 underlying mechanisms miR‑21 in progression cardiomyocyte apoptosis have not been clearly elucidated. The aim current study was to investigate impact target gene, programmed cell death protein 4 (PDCD4), on protective effect cardiomyocytes injured by oxygen‑glucose...
Coronary atherosclerosis (AS) is characterized by the formation of plaque in vessel wall. The structural and functional changes vascular smooth muscle cells (VSMCs) can promote induce instability.To investigate functions mechanism miR-222-5p VSMCs under treatment oxidized low-density lipoprotein (ox-LDL).miR-222-5p expression ox-LDL-treated serum Apolipoprotein E (ApoE) knockout mice was detected reverse transcription quantitative polymerase chain reaction. viability migration were Cell...
The aim of the present study was to investigate effects Beclin 1 knockdown on spontaneous and vitamin K3 (VK3)-regulated autophagy, survival apoptosis in human hepatocarcinoma SMMC-7721 cells, explore potential mechanisms underlying action processes autophagy apoptosis. A recombinant plasmid-expressing small interfering RNA (siRNA) targeting mRNA constructed introduced into cells. expression determined by reverse transcription-polymerase chain reaction Western blotting. Subsequently, impact...
This paper aims to explore the role of circRNA expression profiles and circRNA-associated ceRNA networks in regulation myogenesis longissimus dorsi cattle breeds surviving under subtropical conditions southern China by RNA sequencing bioinformatics analysis. It also provide comprehensive understanding differences muscle fibers expand knowledge molecular that regulate myogenesis. With regard meat quality indicators, results showed LQC had lower pH (P < 0.0001), redness 0.01), shear force...
Doxorubicin-induced cardiomyopathy (DCM) is a life-threatening event. The long noncoding RNAs (lncRNAs) have been reported with close associations DCM, which may provide novel insight into pathophysiological mechanisms of DCM. DCM rat model and cell models were established using doxorubicin. Echocardiography analyses performed to assess cardiac function. We found that testis developmental-related gene 1 (TDRG1) expression was upregulated in rats doxorubicin-treated human umbilical vein...
Abstract Background This study sought to investigate the predictive value and regulatory mechanism of serum miR-499a-5p in sepsis-induced myocardial dysfunction (SIMD). Methods A total 60 patients with sepsis healthy volunteers were enrolled this study. The levels miRNAs (miR-451, miR-378 miR-499a-5p) detected. Receiver operating characteristic curve logistic regression analysis used evaluate diagnostic prognostic SIMD patients. AC16 cells establish model vitro using lipopolysaccharide...
Abstract Considering the significance of lncRNA/miRNA axis in explaining atherosclerosis (AS) progression, this investigation was intended to clarify whether lncRNAs XIST/SNHG5 would regulate AS aetiology by sponging miR‐155, an AS‐promoting molecule. We altogether recruited 367 patients who were examined coronary angiography, and meanwhile, human artery endothelial cells (HCAECs) purchased establish models via ox‐LDL treatment. The study results indicated that lowly expressed highly miR‐155...
Abstract Objectives: Male breast cancer (MBC) is a rare aggressive malignant tumor that accounts for only 1% of all cancers and has worse prognosis compared with female (FBC). However, little unveiled regarding the mechanisms MBC occurrence development, there lack relevant basic research clinical studies at global scale. The rapid development single-cell transcriptomic technologies helped uncover heterogeneity within cell populations microenvironment, as well clonal evolution cells. This...
Objective To evaluate the effect of Weisu granule combined with conventional therapy in treatment chronic atrophic gastritis (CAG). Methods A total 99 CAG patients who met inclusion criteria were randomly divided into control group (49 cases) and observation (50 according to random number table method. The was treated quadruple therapy, while on basis group. Both groups for 90 days. Interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α)...
Objective To establish a stable fluorescent neutrophil-Escherichia coli (E.coli)-metals binary fluorescence dynamic model, and to evaluate the practicability application value of this model. Methods pUC57-mCherry plasmid was isolated transferred clinical E. isolates (ST131) through electroporation, ST131-mCherry then constructed. screened using in-vivo imaging (IVIS) system. Dilution plate method utilized compare growth curve ST131, crystal violet staining used biofilms in 96-well...
Abstract Background Class III anti-arrhythmic drugs (AADs) are used to control heart rhythm or rate in the management of atrial fibrillation (AF). In this study, we evaluated most effective and safe class AADs treat patients with AF. Methods We searched PubMed, Cochrane Library, Web Science, Embase, WanFang databases, as well China National Knowledge Infrastructure from 2014 2019 identify studies that reported use ADDs Results identified 31 articles (24 Chinese 7 English), included 2,894 AF...
Abstract Background: Recently, studies have shown that kinesins(KIF) play an important role in the occurrence and development of many tumors. However, there is no complete understanding KIF family Pan cancer, its immunity tumor microenvironment (TME) unclear.Methods: Based on TCGA database integrated several R packages, we explored relationship between expression genes patient survival, immune subtypes, TME, stem cell correlation, drug sensitivity cancer.Results: We use nine highly expressed...