A5011970401- Bone Metabolism and Diseases
- Bone health and treatments
- Wnt/β-catenin signaling in development and cancer
- Bone health and osteoporosis research
- Trauma and Emergency Care Studies
- TGF-β signaling in diseases
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Connective tissue disorders research
- Aortic Disease and Treatment Approaches
- Pelvic and Acetabular Injuries
- Cardiac Fibrosis and Remodeling
- Fibroblast Growth Factor Research
- Advanced Chemical Sensor Technologies
- Cancer-related gene regulation
- Hip and Femur Fractures
- Signaling Pathways in Disease
- Inflammatory mediators and NSAID effects
- Fluid Dynamics and Thin Films
- Biopolymer Synthesis and Applications
- Aortic aneurysm repair treatments
- Bioinformatics and Genomic Networks
- Cardiovascular Function and Risk Factors
- Antimicrobial Peptides and Activities
- Photodynamic Therapy Research Studies
- Osteoarthritis Treatment and Mechanisms
Sun Yat-sen Memorial Hospital
2021-2025
Sun Yat-sen University
2021-2025
Beijing University of Technology
2025
Southern Medical University
2021-2024
Inner Mongolia Agricultural University
2021-2024
Key Laboratory of Guangdong Province
2021-2024
Third Affiliated Hospital of Southern Medical University
2023
Guangdong Province Stomatological Hospital
2023
City University of Hong Kong
2023
Shandong University
2022
Maintaining proper mitochondrial respiratory function is crucial for alleviating cardiac metabolic disorders during obesity, and mitophagy critically involved in this process. Long non-coding RNA H19 (H19) regulation, but its roles disorders, function, obesity are largely unknown. In study, palmitic acid (PA)-treated H9c2 cell Lep-/- mice were used to investigate vitro vivo, respectively. The effects of on investigated. Moreover, the regulatory mechanisms PA, H19, mitophagy, examined. models...
ABSTRACT Trabecular bone and cortical have different remodeling levels, the underlying mechanisms are not fully understood. In present study, expression of Wnt/β‐catenin signaling its downstream molecules along with mass in trabecular were compared wild‐type mice, constitutive activation β‐catenin (CA‐β‐catenin) mice deletion mice. It was found that level most examined genes such as Wnt3a, β‐catenin, osteocalcin RANKL/OPG ratio significantly higher than CA‐β‐catenin resulted up‐regulated...
Accumulating evidence demonstrates that the Wnt/β-catenin signaling pathway plays a dominant role in bone repair. However, of remodeling phase during fracture healing is currently unknown. In present study, β-catenin was activated at different levels or deleted mice late stage healing, and effects on quality were investigated. Deletion disturbed remodeling, as confirmed by increased resorption decreased formation, significantly strength compared with wildtype mice. addition, constitutive...
Objective: To explore the role of glycolysis in cardiac fibroblast (CF) activation and fibrosis after myocardial infarction (MI). Method:In vivo: 2-Deoxy-D-glucose (2-DG), a inhibitor, was injected into abdominal cavity MI or sham mice every day. On 28th day, function measured by ultrasonic cardiography, hearts were harvested. Masson staining immunofluorescence (IF) used to evaluate area, western blot identify glycolytic level. In vitro, we isolated CF from sham, with 2-DG treatment mice,...
The prognostic significance of N-terminal pro B-type natriuretic peptide (NT-proBNP) in heart failure with preserved ejection fraction (HFpEF) has been well established. HFpEF and atrial fibrillation (AF) commonly coexist, each contributes to poor outcomes independently. Nevertheless, the ability NT-proBNP predict AF patients remains uncertain.
Cyanobacterial cytochrome c6 (Cyt c6) is crucial for electron transfer between the b6f complex and photosystem I (PSI), playing a key role in photosynthesis enhancing adaptation to extreme environments. This study investigates high-resolution crystal structures of Cyt from Synechococcus elongatus PCC 7942 Synechocystis 6803, focusing on its dimerization mechanisms functional implications photosynthesis. was expressed Escherichia coli using dual-plasmid co-expression system characterized both...
Thoracic aortic aneurysm (TAA) is a life-threatening peripheral vascular disease with complex pathogenesis. Altered mitochondrial function in smooth muscle cells has been implicated TAA development. However, the link between functional status and immune cell behavior patients remains largely unexplored. In this study, we analyzed several bulk RNA-seq snRNA-seq datasets of from NCBI-GEO Genome Sequence Archive database, identifying differentially expressed mitochondrial-related genes...
Abstract The activation of the canonical Wnt/β-catenin signaling pathway in both mesenchymal stem cells and osteoblasts has been demonstrated to increase bone mass, showing promise for treatment low volume conditions such as osteoporosis. However, possible side effects manipulating this have not fully addressed. Previously, we reported that constitutive ß-catenin impaired vertebral linear growth. In present study, β-catenin was constitutively activated osteocytes by crossing Catnb+/lox(exon...
Abstract Background Maedi-visna virus (MVV) is a lentivirus that infects monocyte/macrophage lineage cells in sheep, goats, and wild ruminants causes pneumonia, mastitis, arthritis, encephalitis. The immune response to MVV infection complex, complete understanding of its pathogenesis lacking. This study investigated the vivo transcriptomic patterns lung tissues sheep exposed using RNA sequencing technology. Result results indicated 2,739 genes were significantly differentially expressed,...
BACKGROUND: The development of aortic dissection (AD) is closely associated with inflammation. Trem2 (triggering receptor expressed on myeloid cells 2)/Tyrobp (TYRO protein tyrosine kinase-binding protein) signaling pathway critically regulates innate immunity and has emerged as an important target in cardiovascular diseases; however, its role AD remains unclear. METHODS: Transcriptome data from human mouse ADs were used to perform differentially gene–based protein-protein interaction...
Type 1 diabetes mellitus (T1DM) is a pathological condition associated with osteopenia. WNT/β-catenin signaling implicated in this process. Trabecular and cortical bone respond differently to healthy mice. We investigated whether has different effects on trabecular T1DM. first established streptozotocin-induced T1DM mouse model then constitutively activated β-catenin osteoblasts the setting of (T1-CA). The extent loss was greater than that mice, difference consistent reduction expression two...
A disintegrin and metalloproteinase 17 (ADAM17) is a transmembrane protein that widely expressed in various tissues; it mediates the shedding of many membrane-bound molecules, involving cell-cell cell-matrix interactions. We investigated role ADAM17 within mouse cardiac fibroblasts (mCFs) heart fibrosis.mCFs were isolated from hearts neonatal mice. Effects on differentiation mCFs towards myofibroblasts their fibrotic behaviors following induction with TGF-β1 examined. The expression levels...
Mongolian cheese is easily contaminated by foodborne microorganisms, causing diseases and endangering public health. This study aimed to fabricate characterize polylactic acid nanofibrous membranes loaded with lemon essential oil (PLNM), estimating their potential be used as a novel antibacterial material for limiting the development of pathogenic microorganisms on surface. Results showed that fibrous diameter, water contact angle, cumulative release PLNM increased incorporation. Meanwhile,...
Posterior iliac crescent fracture-dislocation is generally considered rotationally unstable and vertically stable. The current study (1) investigated whether vertical instability may occur in posterior (2) analyzed the clinical features of as well treatment strategies. Patients with pelvic fracture who were treated authors’ department from June 2009 to 2012 retrospectively reviewed. This features, including incidence, hemodynamic state, associated injuries, injury severity score, methods for...
Osteoarthritis (OA), which involves total joint damage and dysfunction, is a leading cause of disability worldwide. However, its exact pathogenesis remains unclear. Here, we identified TCF12 as an important regulator the progression OA. qRT-PCR, immunoblotting immunohistochemistry (IHC) were used to detect expression level TCF12. The interaction with downstream factor CXCR4 was assessed by Western blotting, immunofluorescence, qRT-PCR luciferase assays. A mouse model generated examine...