A5110351752- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Neurological disorders and treatments
- Cardiac Structural Anomalies and Repair
- Signaling Pathways in Disease
- MicroRNA in disease regulation
- Cardiac Arrhythmias and Treatments
- Blood Pressure and Hypertension Studies
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Medical Imaging Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Mesenchymal stem cell research
- Muscle and Compartmental Disorders
- Sodium Intake and Health
- Immune Cell Function and Interaction
- Hippo pathway signaling and YAP/TAZ
- Eicosanoids and Hypertension Pharmacology
- Eosinophilic Esophagitis
- Cardiovascular Issues in Pregnancy
- Wnt/β-catenin signaling in development and cancer
- IL-33, ST2, and ILC Pathways
Sun Yat-sen Memorial Hospital
2015-2025
Sun Yat-sen University
2015-2025
Key Laboratory of Guangdong Province
2014-2020
Memorial Hospital
2016
The People's Hospital of Guangxi Zhuang Autonomous Region
2016
The disruption of the balance between fatty acid (FA) uptake and oxidation (FAO) leads to cardiac lipotoxicity, serving as driving force behind diabetic cardiomyopathy (DbCM). Sirtuin 5 (Sirt5), a lysine de-succinylase, could impact diverse metabolic pathways, including FA metabolism. Nevertheless, precise roles Sirt5 in lipotoxicity DbCM remain unknown. This study aims elucidate role underlying mechanism context DbCM. expression myocardial was found be modestly elevated heart failure...
Abstract Prolonged endoplasmic reticulum (ER) stress is the key driving force behind diabetic cardiomyopathy (DCM). Autophagy extensively implicated in adaptive mechanisms for cell survival. Interleukin‐33 (IL‐33) known to be a potent cardiac protector, but its roles DCM, ER stress, and autophagy are currently unknown. We aimed explore effects of IL‐33 on DCM characterize that play DCM. The were characterized both db/db mice palmitic acid (PA)‐treated cardiomyocytes. manipulators used...
Abstract Background Low‐dose single photon emission computed tomography (SPECT) sinograms often suffer from noise due to attenuation during the imaging process. As a result, developing effective denoising methods for low‐dose SPECT images has become an essential research topic. Traditional image struggle balance reduction with preservation of important details, especially in medical applications where accurate structures are critical. Purpose This paper proposes diffusion probabilistic model...
It was found that C‐reactive protein (CRP) could significantly increase the expression and activity of tissue factor (TF), but decrease pathway inhibitor (TFPI) in human umbilical vein endothelial cells (HUVECs) dose‐ time‐dependent manners, which be antagonized by PDTC U0126. CRP also phosphorylated nuclear factor‐kappaB (NF‐κB), IκB‐α ERK1/2 manner. In addition, neutralizing antibody to CD32 (FcgammaR II) attenuate TF TFPI induced CRP. These results suggest may promote coagulation...
Abstract Objectives Yes‐associated protein ( YAP ) has been reported to regulate cell proliferation and differentiation. We aimed characterize the role of in angiotensin II (Ang )‐induced hypertensive vascular remodelling HVR smooth muscle cells VSMC s) phenotypic modulation explore underlying mechanisms. Materials methods An rat model was established by continuous Ang infusion for 2 weeks. Western blotting, qRT ‐ PCR , confocal microscopy were conducted assess expression. ‐sh RNA...
BACKGROUND: The development of aortic dissection (AD) is closely associated with inflammation. Trem2 (triggering receptor expressed on myeloid cells 2)/Tyrobp (TYRO protein tyrosine kinase-binding protein) signaling pathway critically regulates innate immunity and has emerged as an important target in cardiovascular diseases; however, its role AD remains unclear. METHODS: Transcriptome data from human mouse ADs were used to perform differentially gene–based protein-protein interaction...
Endothelial-mesenchymal transition (EndMT) plays a pivotal role in cardiac fibrosis. However, it is unclear whether EndMT involved dyssynchronous heart failure (DHF).Twelve dogs received 3-week rapid right ventricular pacing (RVP) to develop DHF and then were randomly divided into RVP group (n=6; for another 3 weeks) biventricular (BiVP) BiVP weeks), 6 the control group. Contractile function was little better than that (P<0.05), but significant remained 2 groups. induced more fibrosis higher...
Abstract The present study investigated the role of long non‐coding RNA (lncRNA) small nucleolar host gene 16 (SNHG16) in human aortic smooth muscle cell (HASMC) proliferation and migration explored potential link between SNHG16 atherosclerosis. Our results showed that platelet‐derived growth factor (PDGF)‐bb treatment promoted with concurrent up‐regulation HASMCs. Small overexpression HASMC migration, while knockdown suppressed PDGF‐bb‐stimulated bioinformatic analyses possessed...
Abstract Background Single Photon Emission Computed Tomography (SPECT) sinogram restoration for low‐dose imaging is a critical challenge in medical imaging. Existing methods often overlook the characteristics of sinograms, necessitating innovative approaches. Purpose In this study, we introduce Sinogram‐characteristic‐informed network (SCI‐Net) to address SPECT sinograms. Our aim build and train model based on including continuity, periodicity, multi‐scale properties lines others, enhance...
Thyroid dysfunction is prevalent in patients with heart failure (HF) and hypothyroidism related to the adverse prognosis of HF subjects receiving cardiac resynchronization therapy (CRT). We aim investigate whether low-normal free triiodothyronine (fT3) level CRT response euthyroid after implantation.One hundred thirteen who received without previous thyroid disease any treatment affecting hormones were enrolled. All evaluated for function (serum levels fT3, thyroxine [fT4]...
The interactions of sodium balance and response renin–angiotensin–aldosterone system are important for maintaining the hemodynamic stability in physiological conditions. However, influence short-term intake intervention renin–angiotensin (RAS) on hypertensive patients is still unclear. Thus, we conducted a clinical trial to investigate effects RAS patients. One hundred twenty-five primary Chinese were divided into high, moderate, low groups by 24-hour urinary excretion (UNa+). All received...
Numerous previous studies have found that C‑reactive protein (CRP) is associated with cardiac arrhythmia and remodeling. However, the underlying mechanisms of this association remain unclear. Sodium‑calcium exchanger 1 (NCX1) serves an important role in regulation intracellular calcium concentration, which closely related The present study aimed to evaluate effects CRP on NCX1 concentration cardiomyocytes. Primary neonatal mouse ventricular cardiomyocytes were cultured treated varying...
Sepsis-induced cardiomyopathy (SIC) represents a severe complication of systemic infection, characterized by significant cardiac dysfunction.This study examines the role DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Inverted Formin 2 (INF2) in pathogenesis SIC, focusing on their impact mitochondrial homeostasis dynamics.Our research demonstrates that silencing DNA-PKcs alleviates lipopolysaccharide (LPS)-induced cardiomyocyte death dysfunction.Using HL-1 cardiomyocytes...