A5101981272- Blood Pressure and Hypertension Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Acute Kidney Injury Research
- Lipoproteins and Cardiovascular Health
- Congenital heart defects research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coronary Interventions and Diagnostics
- Hormonal Regulation and Hypertension
- Caveolin-1 and cellular processes
- Heart Rate Variability and Autonomic Control
- Cancer, Lipids, and Metabolism
- Receptor Mechanisms and Signaling
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrhythmias and Treatments
- Metabolism, Diabetes, and Cancer
- Cardiovascular Health and Disease Prevention
- Renin-Angiotensin System Studies
- Parathyroid Disorders and Treatments
Sun Yat-sen University
2013-2024
Sun Yat-sen Memorial Hospital
2013-2024
Key Laboratory of Guangdong Province
2013-2023
Institute of Cardiology
2012
Abstract Background A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context hypoxic conditions. The present study aims to explore how miRNA-144 (miR-144), miRNA contained bone marrow mesenchymal cell (MSC)-derived exosomes, exerts effect on cardiomyocyte apoptosis conditions and identify underlying mechanisms. Methods MSCs were cultured using whole adherent method. MSC-derived exosomes isolated total...
BACKGROUND The role of nicotinic acetylcholine receptor alpha7 subunit (a7nAchR) in the treatment acute cerebral ischemia by VNS has not been thoroughly clarified to date. Therefore, this study aimed investigate specific a7nAchR and explore whether process is involved mechanisms VNS-induced neuroprotection rats undergoing permanent middle artery occlusion (PMCAO) surgery. MATERIAL AND METHODS Rats received a7nAChR antagonist (A) or placebo injection for control (AC), followed PMCAO...
SGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay progression atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE-/- mice were fed with western diet empagliflozin was added drinking water for 24 weeks. Empagliflozin treatment significantly alleviated arterial assessed by alizarin red von kossa staining aortic roots reduced lipid levels, while had little effect on body...
It was found that C‐reactive protein (CRP) could significantly increase the expression and activity of tissue factor (TF), but decrease pathway inhibitor (TFPI) in human umbilical vein endothelial cells (HUVECs) dose‐ time‐dependent manners, which be antagonized by PDTC U0126. CRP also phosphorylated nuclear factor‐kappaB (NF‐κB), IκB‐α ERK1/2 manner. In addition, neutralizing antibody to CD32 (FcgammaR II) attenuate TF TFPI induced CRP. These results suggest may promote coagulation...
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective effects MI by preventing augmented intrarenal renin-angiotensin-system (RAS)-induced podocyte injury. Sprague–Dawley rats underwent ligation of their coronary arteries were treated with losartan (20 mg/kg/d) or vehicle for 3 9 weeks. Renal function,...
Percutaneous coronary intervention has been widely used in the treatment of ischemic heart disease, but vascular restenosis is a main limitation percutaneous intervention. Our previous work reported that caveolin-1 had key functional role intimal hyperplasia, whereas whether Cavin-1 (another important caveolae-related protein) was involved still unknown. Therefore, we will investigate effect on neointimal formation.
Background Whether an addition of OAC to double antiplatelet therapy for patients with indication chronic oral anticoagulation undergoing PCI-S may improve clinical outcomes is still debated. This meta-analysis aimed update and re-compare the benefits risks triple antithrombotic (TT) anti-platelet (DAPT) after in who requiring percutaneous coronary interventions stenting (PCI-s). Methods Ten reports observational retrospective or prospective studies were retrieved, including a total 6296...
Renal impairment is a frequent accompaniment post-myocardial infarction (MI) heart failure. However, the mechanisms and predictors are yet poorly understood. The present study aimed to explore early markers for renal test hypothesis that angiotensin II type 1 receptor (AT1R) blocker exerted renoprotection by regulating local receptors post-MI Sprague-Dawley rats underwent ligation of left descending coronary artery were treated with losartan (20 mg/kg/day) or vehicle 3 9 weeks. Samples...
Amiodarone-associated torsade de pointes (Tdp) has been reported increasingly in China recent years. In this study, we made clinical analysis of amiodarone-associated Tdp Chinese people.Two major medical databases were searched to identify articles published during the last 26 years that presented data on proarrhythmic events. The divided into two categories: case reports and observational studies.Fifty-two Chinese-language with 98 patients 2 registered our hospital, total 100 about Tdp,...