A5100665955- MicroRNA in disease regulation
- Chronic Kidney Disease and Diabetes
- Electrospun Nanofibers in Biomedical Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- interferon and immune responses
- Cardiovascular Syncope and Autonomic Disorders
- NF-κB Signaling Pathways
- Cardiovascular Function and Risk Factors
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Diabetes Management and Research
- Heart Rate Variability and Autonomic Control
- Congenital heart defects research
- Kruppel-like factors research
- Cardiac Imaging and Diagnostics
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Reproductive System and Pregnancy
- Apelin-related biomedical research
Shandong University
2009-2025
First Affiliated Hospital of Bengbu Medical College
2023-2024
Sun Yat-sen University
2010-2023
Sun Yat-sen Memorial Hospital
2011-2023
Key Laboratory of Guangdong Province
2013-2021
Shandong Provincial Hospital
2009
Abstract Background A growing body of evidence suggests that stem cell-derived exosomal microRNAs (miRNAs) could be a promising cardioprotective therapy in the context hypoxic conditions. The present study aims to explore how miRNA-144 (miR-144), miRNA contained bone marrow mesenchymal cell (MSC)-derived exosomes, exerts effect on cardiomyocyte apoptosis conditions and identify underlying mechanisms. Methods MSCs were cultured using whole adherent method. MSC-derived exosomes isolated total...
As China’s urban development enters the era of stock optimization, practice transforming and utilizing spaces under overpasses is rapidly gaining momentum. Converting these underpass into sports areas has emerged as a new form creating public space. Understanding perceptions users from different age groups towards holds significant guiding value for optimizing design such improving quality service. Taking Yanshan Interchange Lowline Park in Jinan an example, this research applied methods...
In normal endometrium, stromal factors regulate the growth of epithelial cells. However, cells in endometriotic lesions display increased proliferation and decreased apoptosis. This work tested hypothesis that endometriosis lose ability to survival signaling cell Primary normal, eutopic ectopic were cultured presence medium conditioned by endometrial Endometriotic showed higher Survivin expression than Conditioned (CM) from or significantly inhibited AKt phosphorylation CM did not have an...
Atherosclerosis (AS) is a chronic metabolic disease in arterial walls, characterized by lipid deposition and persistent aseptic inflammation. AS regarded as the basis of variety cardiovascular cerebrovascular diseases. It widely acknowledged that macrophages would become foam cells after internalizing lipoprotein particles, which an initial factor atherogenesis. Here, we showed influences Bruton's tyrosine kinase (BTK) macrophage-mediated how BTK regulates inflammatory responses AS. Our...
The mechanisms and mediators underlying common renal impairment after myocardial infarction (MI) are still poorly understood. present study aimed to test the hypothesis that angiotensin II type 1 receptor blockers (ARBs) provides renoprotective effects MI by preventing augmented intrarenal renin-angiotensin-system (RAS)-induced podocyte injury. Sprague–Dawley rats underwent ligation of their coronary arteries were treated with losartan (20 mg/kg/d) or vehicle for 3 9 weeks. Renal function,...
Renal impairment is a frequent accompaniment post-myocardial infarction (MI) heart failure. However, the mechanisms and predictors are yet poorly understood. The present study aimed to explore early markers for renal test hypothesis that angiotensin II type 1 receptor (AT1R) blocker exerted renoprotection by regulating local receptors post-MI Sprague-Dawley rats underwent ligation of left descending coronary artery were treated with losartan (20 mg/kg/day) or vehicle 3 9 weeks. Samples...
Activation of cardiac fibroblasts (CF) is crucial to fibrosis. We constructed a fibroblast-related competing endogenous RNA (ceRNA) network. Potential functions related fibrosis "hub genes" in this ceRNA network were explored. The Gene Expression Omnibus database was searched for eligible datasets. Differentially expressed messenger (m)RNA (DE-mRNA) and long non-coding (lnc)RNA (DE-lncRNA) identified. microRNA predicted validated. A visualized by Cytoscape, crosstalk Single Set Enrichment...
With the progress of shock therapy and establishment promotion methods such as thrombolytic percutaneous coronary intervention (PCI), many tissues organs have been reperfused after ischemia which may cause even worse disorder called ischemia-reperfusion injury (IRI). mRNAs found to significant impacts on through various mechanisms. In view accessibility from blood, we aimed find association between mRNA ischemia-reperfusion. We used GSE83472 dataset Gene Expression Omnibus (GEO) database...
To investigate renal expression level of STING in mice with ischemia-reperfusion injury (IRI) and its regulatory role IRI.
This study aimed to compare the renal impairments in post-myocardial infarction (MI) rats with normal biochemical parameters at baseline versus without cardiac dysfunction and explore potential mechanisms involved these differences. Sprague–Dawley permanent ligation of coronary artery were used as MI models. Renal function, histological molecular changes compared between reduced ejection fraction (EF) (EF < 40%) group preserved EF ≥ 3 or 9 weeks post-MI. The results revealed that blood...
Background: Little is known about characteristics of dynamic electrocardiogram (DCG), heart rate (HR) variability (HRV), and invasive electrophysiological study (EPS) in the presence, pattern, stage vasovagal syncope (VVS) during head-up tilt test (HUTT). The present aims to explore predictive value these tests for HUTT outcomes with underlying mechanisms. Subjects Methods: This retrospective consecutively enrolled 519 patients VVS from January 2007 December 2017. Parameters DCG, HRV, EPS...
Objective: The head-up tilt test (HUTT) is widely used but time-consuming and not cost-effective to evaluate patients with vasovagal syncope (VVS). present study aims verify the hypothesis that ambulatory blood pressure (BP) monitoring (ABPM) simplistic may be potential alternatives HUTT. Methods: consecutively enrolled 360 who underwent HUTT VVS. BP), heart rate (HR), BP/HR ratios derived from ABPM were evaluated predict presence, pattern, stage of during Results: Mixed response was...
As peri-prosthetic aseptic loosening is one of the main causes implant failure, inhibiting wear particles induced macrophages inflammation considered as a promising therapy for AL to expand lifespan implant. Here, we aim at exploring role p110δ, member class IA PI3K family, and Krüppel-like factor 4 (KLF4) in titanium (TiPs) macrophages-inflammation osteolysis. Firstly, IC87114, inhibitor p110δ siRNA targeting were applied experiments including ELISA immunofluorescence assay conducted...
Osteoarthritis, the most common degenerative joint disease, significantly impairs life quality and labor capability of patients. Synovial inflammation, initiated by HMGB1 (High mobility group box 1)-induced activation macrophage, precedes other pathological changes. As an upstream regulator NF-κB (nuclear factor-kappa B) MAPK (mitogen-activated protein kinase) signaling pathway, TAK1 (TGF-β activated kinase 1) participates in macrophage activation, while its function osteoarthritis remains...
Aseptic inflammation is the main factor causing aseptic loosening of artificial joints. Studies have shown that inflammatory cells can activate STING (stimulator interferon genes, STING) after being stressed. This study aims to explore specific mechanism in joints, and provide new strategies for disease prevention. Titanium particles with a diameter 1.2-10 μm were prepared stimulate macrophages (RAW 264.7) simulate periprosthetic microenvironment. A lentiviral vector targeting gene was...