A5101434575- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bone health and osteoporosis research
- Periodontal Regeneration and Treatments
- Bone and Dental Protein Studies
- Bone health and treatments
- dental development and anomalies
- Dental Implant Techniques and Outcomes
- TGF-β signaling in diseases
- Dental materials and restorations
- Connective tissue disorders research
- Cervical Cancer and HPV Research
- Parathyroid Disorders and Treatments
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- 3D Printing in Biomedical Research
- Precipitation Measurement and Analysis
- Silk-based biomaterials and applications
- interferon and immune responses
- Satellite Communication Systems
- Hydrocarbon exploration and reservoir analysis
- Telecommunications and Broadcasting Technologies
- Cytokine Signaling Pathways and Interactions
Tongji University
2019-2025
Shanghai Stomatological Hospital
2024
Central South University
2021-2024
Guangzhou University of Chinese Medicine
2022
Texas A&M University
2014-2021
Shanghai Ninth People's Hospital
2016-2018
Shanghai Jiao Tong University
2016-2018
National Clinical Research Center for Digestive Diseases
2018
Indiana University School of Medicine
2017
Texas A&M Health Science Center
2015
Abstract: Nanotopography modification is a major focus of interest in current titanium surface design; however, the influence nanostructured on human cell/bacterium behavior has rarely been systematically evaluated. In this study, homogeneous nanofiber structure was prepared (Nano) by alkali-hydrothermal treatment, and effects Nano behaviors MG-63 osteoblasts, gingival epithelial cells (HGECs) fibroblasts (HGFs) were evaluated comparison with smooth (Smooth) polishing micro-rough (Micro)...
It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in stress-induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype is mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which normally highly...
Abstract The activation of the canonical Wnt/β-catenin signaling pathway in both mesenchymal stem cells and osteoblasts has been demonstrated to increase bone mass, showing promise for treatment low volume conditions such as osteoporosis. However, possible side effects manipulating this have not fully addressed. Previously, we reported that constitutive ß-catenin impaired vertebral linear growth. In present study, β-catenin was constitutively activated osteocytes by crossing Catnb+/lox(exon...
The effective transportation of oxygen, nutrients, and metabolic wastes through new blood vessel networks is key to the survival engineered constructs in large bone defects. Adipose-derived mesenchymal stem cells (ADSCs), which are regarded as excellent candidates for both engineering, preferred option restoration massive Therefore, we propose induce ADSCs into osteogenic endothelial differently. A modified hierarchical mesoporous bioactive glass (MBG) scaffold with an enhanced compressive...
Bone-forming osteoblasts have been a cornerstone of bone biology for more than century.Most research toward and diseases center on osteoblasts.Overlooked are the 90% cells, called osteocytes.This study aims to test hypothesis that osteocytes but not directly build mineralized structures, defects in lead onset hypophosphatemia rickets.The was tested by developing modifying multiple imaging techniques, including both vivo vitro models plus two types rickets (Dmp1-null Hyp, Phex mutation mice),...
Abstract The low in vivo survival rate of scaffold-seeded cells is still a challenge stem cell-based bone regeneration. This study seeks to use silk hydrogel deliver more into defect area and prolong the viability these after implantation. Rat marrow were mingled with hydrogels at concentrations 1.0 × 10 5 /mL, 6 /mL 7 before gelation, added dropwise scaffold applied rat calvarial defect. A cell tracing experiment was included observe preservation function. results show that exhibited best...
A promising strategy to accelerate bone generation is deliver a combination of certain growth factors the integration site via controlled spatial and temporal delivery mode. Here, composite hydrogel incorporating poly(lactide-co-glycolide) (PLGA) microspheres was accordingly prepared load osteogenic rhBMP-2 angiogenic rhVEGF165 in required manner. In addition, 2-N,6-O-sulphated chitosan (26SCS), which synergetic factor factors, incorporated as well. The system showed similar release...
Patients with hypophosphatemia rickets (including DMP1 mutations) develop severe osteoarthritis (OA), although the mechanism is largely unknown. In this study, we first identified expression of in hypertrophic chondrocytes using immunohistochemistry (IHC) and X-gal analysis Dmp1-knockout-lacZ-knockin heterozygous mice. Next, characterized OA-like phenotype Dmp1 null mice from 7-week-old to one-year-old multiple techniques, including X-ray, micro-CT, H&E staining, Goldner scanning electronic...
Searching for effective osteoinduction factors with higher specificity and biosafety the preparation of biomimetic materials, which mimic natural bone extracellular matrix (ECM), seems to be an optimum strategy achieving ideal regeneration.
In satellite communication system, rain attenuation is one of the most important reasons for signal fading transmitted at Ka band (30/20GHz). this paper, based on ITU recommendation rainfall prediction model, we obtain value specific area in systems band, premise knowing that a certain follows lognormal distribution, then statistical distribution parameters are derived detail by method least squares curve fitting. After QPSK modulation, polluted additive noise AWGN channel. We analyze and...
Dentin matrix protein 1 (DMP1) is essential to odontogenesis. Its mutations in human subjects lead dental problems such as deformities, hypomineralization and periodontal impairment. Primarily, DMP1 considered an extracellular that promotes hydroxyapatite formation activates intracellular signaling pathway via interacting with αvβ3 integrin. Recent vitro studies suggested might also act a transcription factor. In this study, we examined whether full-length could function factor the nucleus...
Abstract It has been well-validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which is normally highly...
It has been well validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in stress-induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype is mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which normally highly...
It has been well-validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in stress-induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which is normally highly...
Objective: This study compares human papillomavirus (HPV) vaccination intentions and associated factors among female undergraduate students in Changsha, a resource-rich region, Jishou, resource-limited area China. Methods: An online cross-sectional survey conducted between March May 2018 assessed HPV intentions, awareness, vaccine cervical screening knowledge, perceived efficacy safety of vaccine, risk perceptions about cancer, worries concerns, emotional impacts gynecological lesions linked...
It has been well-validated that chronic psychological stress leads to bone loss, but the underlying mechanism remains unclarified. In this study, we established and analyzed unpredictable mild (CUMS) mice investigate miRNA-related pathogenic involved in induced osteoporosis. Our result found these CUMS exhibited osteoporosis phenotype mainly attributed abnormal activities of osteoclasts. Subsequently, miRNA sequencing other analysis showed miR-335-3p, which is normally highly expressed...
Objective This study aimed to examine the previous uptake of cervical cancer screening and intention be screened its associated factors among women living with HIV in China. Methods We conducted a cross-sectional survey 213 collect information about behaviour, demographics, knowledge screening, perception symptom severity. Results Seventy-eight (36.6%) had undergone 83 (61.5%) nonscreened future. Using multivariate analysis, who more (OR = 2.373, 95% CI 1.593–3.534, p 0.000) at least one...