A5054764279- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Antimicrobial Peptides and Activities
- SARS-CoV-2 and COVID-19 Research
- Vector-Borne Animal Diseases
- Mosquito-borne diseases and control
- Influenza Virus Research Studies
- Insect Resistance and Genetics
- Vector-borne infectious diseases
- Immune Response and Inflammation
- Synthesis and biological activity
- Animal Virus Infections Studies
- Insect and Pesticide Research
- Animal Disease Management and Epidemiology
- Biochemical and Structural Characterization
- Computational Drug Discovery Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Venomous Animal Envenomation and Studies
- interferon and immune responses
- Research on Leishmaniasis Studies
- Respiratory Support and Mechanisms
- Infection Control and Ventilation
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
Shanxi Agricultural University
2022-2025
Guangdong Medical College
2025
Fujian Agriculture and Forestry University
2024
Chinese Academy of Sciences
2018-2023
Kunming Institute of Zoology
2018-2023
Chengdu Medical College
2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
University of Hong Kong
2020-2021
University of Chinese Academy of Sciences
2021
Google (United States)
2020
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death. However, origin excessive damages caused by SARS-CoV-2 remains largely unknown. Here we show that envelope (2-E) protein alone is able to cause acute respiratory distress syndrome (ARDS)-like in vitro vivo. 2-E proteins were found form a type pH-sensitive cation channels bilayer lipid membranes. As observed SARS-CoV-2-infected cells, heterologous expression induced rapid cell death various susceptible...
Abstract COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic, which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli causes severe lung infection damage. To better understand the molecular basis of this disease, we sought characterize responses alveolar epithelium its adjacent microvascular endothelium viral under co-culture system. massive virus replication dramatic organelles remodeling in epithelial cells, alone. While, affected...
New therapeutic agents for Candida albicans vaginitis are urgently awaiting to be developed because of the increasing antibiotic resistance C. albicans. Antimicrobial peptides (AMPs) one most promising choices next-generation antibiotics. In this study, novel were designed based on snake venom antimicrobial peptide cathelicidin-BF promote anti-C. activity and decrease side-effects. The designing strategies include substitutions charged or hydrophobic amino acid residues noncharged polar...
Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic worldwide. Currently, however, no effective drug or vaccine is available to treat prevent the resulting disease 2019 (COVID-19). Here, we report our discovery of promising anti-COVID-19 candidate, lipoglycopeptide antibiotic dalbavancin, based on virtual screening FDA-approved peptide library combined in vitro and vivo functional antiviral assays. Our results showed that dalbavancin...
Coronavirus disease 2019 (COVID-19)2 has emerged as a global pandemic. However, effective treatments for this are still unclear, safe and efficient therapies urgently needed. Qingfei Paidu decoction (QPD)3 is strongly recommended in the Chinese Novel Pneumonia Diagnosis Treatment Plan (Provisional 6th Edition). clinical research data on effects of QPD COVID-19 scarce. Our study aimed to explore combined treatment with Western medicine COVID-19. In study, 63 patients confirmed were analyzed....
As of June 2020, Coronavirus Disease 2019 (COVID-19) has killed an estimated 440 000 people worldwide, 74% whom were aged ≥65 years, making age the most significant risk factor for death caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To examine effect on death, we established a SARS-CoV-2 infection model in Chinese rhesus macaques ( Macaca mulatta) varied ages. Results indicated that infected young manifested impaired function, active viral replication,...
Abstract Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and high-risk factor for severe illness death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, NET component, can perturb the interaction between SARS-CoV-2 spike protein its ACE2 receptor, which mediates viral entry into cells. At present, however, levels cathelicidin antimicrobial...
Wild birds and waterfowl serve as the natural reservoirs of avian influenza viruses (AIVs). When AIVs originating from wild cross species barriers to infect mammals or humans, they pose a significant threat public health. The H12 subtype primarily circulates in birds, with relatively few isolates reported worldwide, evolutionary biological characteristics remain largely unknown. In this study, we analyzed spatiotemporal distribution worldwide conducted comprehensive investigation into an...
Background Osteoporotic vertebral compression fracture (OVCF) has been extensively treated clinically using percutaneous augmentation (PVA), which includes kyphoplasty and vertebroplasty. Postoperative refracture is a common complication after PVA, but the associated factors specific mechanisms behind these fractures are not entirely clear. Questions/purposes In systematic review meta-analysis, we asked: What were with increased or decreased odds of PVA for OVCF? Methods Following Preferred...
Flaviviruses are single-stranded RNA viruses predominantly transmitted by the widely distributed Aedes mosquitoes in nature. As important human pathogens, geographic reach of and their threats to public health increasing, but there is currently no approved specific drug for treatment. In recent years, development peptide antivirals has gained much attention. Natural host defense peptides which uniquely evolved protect hosts have been shown antiviral properties. this study, we firstly...
Zika virus (ZIKV) is a mosquito-borne belonging to the genus Flavivirus and has reemerged in recent years with epidemic potential. ZIKV infection may results severe syndromes such as neurological complications microcephaly newborns. Therefore, become global public health threat currently there no approved specific drug for its treatment. Animal venoms are important resources of novel drugs. Cathelicidin-BF (BF-30) defensive peptide identified from Bungarus fasciatus snake venom been shown be...
The Asian elephant (
African swine fever virus (ASFV) is a large double-stranded DNA and causes high mortality in swine. ASFV can be transmitted by biological vectors, including soft ticks genus Ornithodoros but not hard ticks. However, the underlying mechanisms evolved vectorial capacity of are well-understood. Here, we found that defensin-like peptide toxin OPTX-1 identified from papillipes inhibits enzyme activity pS273R protease with K i =0.821±0.526μM shows inhibitory on replication ASFV. The analogs show...
As an important source of air pollutant, airborne particulate matter (PM) has become a major threat to public health. Orchitis is characterized by acute or chronic testicular inflammation and primary cause male infertility. Although accumulating evidence indicates that PM exposure associated with increased infertility rates, the mechanism which involved not well understood. Here, we found short-term activated NF-κB signaling in mouse Leydig cells testes leading asymptomatic orchitis....
Avian infectious bronchitis (IB) is a highly contagious disease caused by virus (IBV), which prevalent in many countries worldwide and causes serious harm to the poultry industry. At present, commercial IBV vaccines have been used for prevention control of IB; however, IB outbreaks occur frequently. In this study, two new strains IBV, SX/2106 SX/2204, were isolated from flocks immunized with H120 vaccine central China. Phylogenetic recombination analysis indicated that SX/2106, was clustered...
Lyme spirochetes have coevolved with ticks to optimize transmission hosts using tick salivary molecules (TSMs) counteract host defenses. TSMs modulate various molecular events at the tick-host interface. Lymphotoxin-beta receptor (LTβR) is a vital immune and plays protective roles in immunity against microbial infections. We found that Ltbr knockout mice were more susceptible disease spirochetes, suggesting involvement of LTβR signaling tick-borne Borrelia infection. Further investigation...