A5004465468- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Bacillus and Francisella bacterial research
- Pregnancy and Medication Impact
- interferon and immune responses
- Intracerebral and Subarachnoid Hemorrhage Research
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Drug Transport and Resistance Mechanisms
- Vascular Tumors and Angiosarcomas
- Developmental Biology and Gene Regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive System and Pregnancy
- Soft Robotics and Applications
- Liver Diseases and Immunity
- Electrospun Nanofibers in Biomedical Applications
- Sarcoma Diagnosis and Treatment
- Congenital heart defects research
- Bacteriophages and microbial interactions
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- RNA modifications and cancer
Shanghai Institute of Materia Medica
2020-2025
Chinese Academy of Sciences
2020-2025
People's Liberation Army 401 Hospital
2024
Qingdao University
2016-2024
Affiliated Hospital of Qingdao University
2024
University of Chinese Academy of Sciences
2018-2023
Puyang Vocational and Technical College
2022
Center for Excellence in Molecular Cell Science
2018
Qingdao Municipal Hospital
2016
East China Normal University
2008
Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death. However, origin excessive damages caused by SARS-CoV-2 remains largely unknown. Here we show that envelope (2-E) protein alone is able to cause acute respiratory distress syndrome (ARDS)-like in vitro vivo. 2-E proteins were found form a type pH-sensitive cation channels bilayer lipid membranes. As observed SARS-CoV-2-infected cells, heterologous expression induced rapid cell death various susceptible...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens current Coronavirus (COVID-19) vaccine campaigns. In addition to the emergence of resistant SARS-CoV-2 variants, little is known about how evades antibodies. Here, we report novel mechanism extracellular vesicle (EV)-mediated cell-to-cell transmission SARS-CoV-2, which facilitates escape from These EVs, initially observed in...
In November 2021, a new SARS-CoV-2 variant emerged in South Africa and was designated the fifth of concern named Omicron. It detected more than 26 countries worldwide, including China. The Omicron is highly transmissible has extensive morbidity, which raised concerns related to antiviral therapy. Recent reports have revealed that exhibits longer cycle viral shedding decreased replication capacity results substantially attenuated lung pathology, indicating pathogenic ability lower previous...
Introduction Mixed Lineage Kinase Domain-Like Protein (MLKL), as the executor of necroptosis and a critical factor in inflammation, has been shown to be associated with progression hemorrhagic stroke. Studies identified MLKL is promoting this process, suggesting its potential therapeutic target mitigate posthemorrhagic stroke damage. However, mechanisms by which functions process intracerebral hemorrhage (ICH)-induced damage remain unclear. Methods Here, we explored correlation between...
Abstract Extracellular vesicles (EVs) are shown to be a novel viral transmission model capable of increasing virus's tropism. According our earlier research, cells infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) or transfected envelope protein plasmids generate type EVs that micrometer‐sized and able encase virus particles. Here, we showed the capacity these invade various animals both in vitro vivo independent angiotensin‐converting enzyme receptor. First, via...
The homeobox (Hox) genes Hoxd12 and Hoxd13 control digit patterning limb formation in tetrapods. Both show strong expression the bud during embryonic development, are highly conserved across vertebrates, mutations that associated with carpal, metacarpal, phalangeal deformities. most dramatic evolutionary reorganization of mammalian has occurred cetaceans (whales, dolphins, porpoises), which hind limbs have been lost forelimbs evolved into paddle-shaped flippers. We reconstructed phylogeny...
Summary Cytokine storm and multi-organ failure are the main causes of SARS-CoV-2-related death. However, origin virus’ excessively damaging abilities remains unknown. Here we show that SARS-CoV-2 envelope (2-E) protein alone is sufficient to cause acute respiratory distress syndrome (ARDS)-like damage in vitro vivo . Overexpression 2-E induced rapid pyroptosis-like cell death various susceptible cells robust secretion cytokines chemokines macrophages. Intravenous administration purified into...
Heart failure (HF) is a major public health issue with high mortality and morbidity. This study aimed to find potential diagnostic markers for HF by the combination of bioinformatics analysis machine learning, as well analyze role immune infiltration in pathological process HF. The gene expression profiles 124 patients 135 nonfailing donors (NFDs) were obtained from six datasets NCBI Gene Expression Omnibus (GEO) database. We applied robust rank aggregation (RRA) weighted co-expression...
Abstract Predicting pathogenicity of Omicron sub-variants is critical for assessing disease dynamics and developing public health strategies. As an important virulence factor, SARS-CoV-2 envelope protein (2-E) causes cell death acute respiratory distress syndrome (ARDS)-like pathological damages. Evaluation 2-E mutations might offer clues to forecast. Here, the frequency lethality 92 in five early “variants concern” (VOCs, Alpha, Beta, Gamma, Delta, BA.1, BA.2, BA.3, BA.4, BA.5) were...
The aim of the present study was to investigate protein expression profiling pregnane X receptor (PXR) and ATP-binding cassette sub-family B member 1 (ABCB1; also known as MDR1 or P-gp), in peripheral blood mononuclear cells (PBMCs) cancerous tissues cases non-small cell lung cancer (NSCLC). Furthermore, aimed assess feasibility predicting drug resistance through medium PBMCs. Of subjects included study, 37 were histopathologically diagnosed with NSCLC 17 control patients without cancer....
Nephrotic syndrome is a common disease of the urinary system. The aim this study to explore effect astragalus polysaccharides (APS) on multidrug resistance gene 1 (MDR1) and P-glycoprotein 170 (P-gp170) in adriamycin nephropathy rats underlying mechanisms.
Backgrounds Cuprotosis is a newly discovered programmed cell death by modulating tricarboxylic acid cycle. Emerging evidence showed that cuprotosis-related genes (CRGs) are implicated in the occurrence and progression of multiple diseases. However, mechanism cuprotosis heart failure (HF) has not been investigated yet. Methods The HF microarray datasets GSE16499, GSE26887, GSE42955, GSE57338, GSE76701, GSE79962 were downloaded from Gene Expression Omnibus (GEO) database to identify...
<title>Abstract</title> Extracellular vesicles (EVs) facilitate cell-to-cell communication, and some enveloped viruses utilize these as carriers to mediate viral transmission. SARS-CoV-2 envelope protein (2-E) forms a cation channel overexpression of 2-E led the generation distinct type large extracellular vesicle (2-E-EV). Although 2-E-EV has been demonstrated transmission in receptor-independent way, characteristics biogenesis mechanism remained enigmatic. We identified novel EV. Via...
Abstract SARS-CoV-2 Omicron variant is highly transmissible and extensive morbidity, which has raised concerns for antiviral therapy. In addition, the molecular basis attenuated pathogenicity replication capacity of remains elusive. Here, we report first time that a high-frequency mutation T9I on 2-E forms non-selective ion channel with abolished calcium permeability reduced acid sensitivity compared to WT channel. caused less cell death weaker cytokine production. The property changes might...