A5066117025- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Alkaloids: synthesis and pharmacology
- Sphingolipid Metabolism and Signaling
- Berberine and alkaloids research
- Biochemical Analysis and Sensing Techniques
- Clostridium difficile and Clostridium perfringens research
- Exercise and Physiological Responses
- Gut microbiota and health
- Alzheimer's disease research and treatments
- Connexins and lens biology
- Acupuncture Treatment Research Studies
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Ginger and Zingiberaceae research
- Heart Rate Variability and Autonomic Control
- Healthcare and Venom Research
- Gout, Hyperuricemia, Uric Acid
- Medicinal Plants and Bioactive Compounds
- Vagus Nerve Stimulation Research
- Biochemical Acid Research Studies
- Pharmacological Effects of Natural Compounds
- Glaucoma and retinal disorders
Nanjing University of Chinese Medicine
2014-2025
Northwest A&F University
2024
Depressive disorder is a common mental characterized by depressed mood and loss of interest or pleasure. As the Herbal medicines are mainly used as complementary alternative therapy for depression. This study aimed at exploring antidepressant activity Huang-lian Jie-du Decoction (HLJDD), evaluating active components potential depression-associated targets. HLJDD was administered on chronic unpredictable mild stress-induced (CUMS) depressive mice. Behavior evaluation performed through force...
Berberine, which is a potential antidepressant, exhibits definite efficiency in modulating the gut microbiota. Depressive behaviors mice induced using chronic unpredictable mild stress (CUMS) stimulation were evaluated by behavioral experiments. The markers of neurons and synapses measured immunohistochemical staining. An enzyme-linked immunosorbent assay was adopted to analyze serum inflammatory cytokines levels neurotransmitters LC-MS/MS. Untargeted metabolomics tryptophan metabolism...
Neuroinflammation is one of the major pathogeneses in Alzheimer's disease (AD) and mainly involves abnormal inflammatory activation microglia by multiple pathological stimuli. The treatment AD remains a challenge due to multifactorial characterization inefficient ability therapeutic drugs permeate through blood‒brain barrier (BBB). Accordingly, drug combination carrier delivery have become important tools for diseases, especially AD.Inflammatory cytokine levels microglia, including NO,...
Abnormal sphingolipid metabolism is closely related to the occurrence and development of Alzheimer's disease (AD). With heat-clearing detoxifying effects, Huanglian Jiedu decoction (HLJDD) has been used treat dementia improve learning memory impairments.To study therapeutic effect HLJDD on AD as it relates metabolism.The level sphingolipids in brains APP/PS1 mice supernatant β-amyloid (Aβ)25-35-induced BV2 microglia was detected by HPLC-QTOF-MS HPLC-QTRAP-MS techniques, respectively. The...
The balance of gut microbiota affects uric acid synthesis and excretion, influencing the development hyperuricemia. This study aimed to investigate effects mechanisms probiotics on hyperuricemia adenine- potassium oxonate-induced colonic damage. After two months gavage at 10
Amelioration of neuroinflammation via modulating microglia is a promising approach for cerebral ischemia therapy. The aim the present study was to explore gut-brain axis signals in berberine-modulating polarization following ischemia. potential pathway determined through analyzing activation vagus nerve, hydrogen sulfide (H2 S) metabolism, and cysteine persulfides transient receptor vanilloid 1 (TRPV1) receptor. microenvironment feature explored with metabolomics assay. data indicated that...
Previous studies proved the benefits of electroacupuncture (EA) on heart in ischemia reperfusion injury and chronic failure. However, role EA sepsis-induced cardiac dysfunction has rarely been elucidated before. In this study, we aimed to investigate effects a rat model sepsis speculate underlying mechanisms.Sepsis was induced by cecum ligation puncture anesthetized rats. at acupoint "Neiguan (PC6)" applied 0.5 h after induction for 20 min. Heart rate variability obtained immediately...
Serious mental illness is a disease with complex etiological factors that requires multiple interventions within holistic system. With heat-clearing and detoxifying effects, Coptis chinensis Franch. mainly used to treat serious illness.To explore the underlying mechanisms therapeutic effect by which treats illnesses at level.A viable network pharmacology approach was adopted obtain potential active ingredients of Franch., illnesses-related targets signaling pathways. The interactions between...
Background: This study aimed to analyze the protective effects of a saponin extract from Radix Pseudostellariae (RP) on retinal laser injury based photocoagulation model. Methods: Fifty-eight rabbits were randomly divided into three groups: Group A (saponin orally), B (physiological saline), and C (control). The animals sacrificed 1 day, 7 days, 14 30 days after lesions evaluated with fundus photography, light microscopy, electron microscopy. Superoxide dismutase (SOD) malondialdehyde (MDA)...
Introduction: Neuroinflammation mediated by microglia is widely considered the primary cause and pathological process of anxiety. Abnormal glycolysis observed during activation. However, whether regulating Warburg effect in can effectively intervening anxiety characterized abnormal or persistent inflammation its potential mechanisms have not been elucidated.Objectives: This study focused on coptisine (Cop), a natural alkaloid that regulates function affecting anxiety.Methods: The effects Cop...
IntroductionNeuroinflammation mediated by microglia is widely considered the primary cause and pathological process of anxiety. Abnormal glycolysis observed during activation. However, whether regulating Warburg effect in can effectively intervening anxiety characterized abnormal or persistent inflammation its potential mechanisms have not been elucidated.ObjectivesThis study focused on coptisine (Cop), a natural alkaloid that regulates function affecting anxiety.MethodsThe effects Cop...