A5100642838- Circular RNAs in diseases
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- MicroRNA in disease regulation
- Plant Pathogens and Fungal Diseases
- Synthesis of Organic Compounds
- Pancreatic function and diabetes
- Biological Activity of Diterpenoids and Biflavonoids
- Receptor Mechanisms and Signaling
- Phytoestrogen effects and research
- Flavonoids in Medical Research
- Polyamine Metabolism and Applications
- Advanced biosensing and bioanalysis techniques
- Genetics and Neurodevelopmental Disorders
- Plant-based Medicinal Research
- Aldose Reductase and Taurine
- Enzyme Catalysis and Immobilization
- Natural Compound Pharmacology Studies
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Bacterial biofilms and quorum sensing
- Drug Transport and Resistance Mechanisms
- Bacterial Identification and Susceptibility Testing
- Ubiquitin and proteasome pathways
- Higher Education and Teaching Methods
Changchun University of Chinese Medicine
2024
First Hospital of Jilin University
2024
Jilin University
2024
Zhengzhou University
2022-2023
Henan Provincial People's Hospital
2022-2023
Henan University
2008-2022
Tianjin University of Technology
2018
Tianjin Institute of Pharmaceutical Research (China)
2012-2015
Nanjing University of Chinese Medicine
2005-2014
Abstract The degradation of aggregation-prone tau is regulated by the ubiquitin-proteasome system (UPS) and autophagy, which are impaired in Alzheimer’s disease (AD) related tauopathies causing aggregation. Protein ubiquitination with linkage specificity determines fate proteins that can be either degradative or stabilization signals. While linear M1-linked on protein aggregates a signaling hub recruits various ubiquitin-binding for coordinated actions turnover inflammatory NF-kB activation,...
L-type amino acid transporter 1 (LAT1), overexpressed on the membrane of various tumor cells, is a potential target for tumor-targeting therapy. This study aimed to develop LAT1-mediated chemotherapeutic agent. We screened doxorubicin modified by seven different large neutral acids. The aspartate-modified (Asp-DOX) showed highest affinity (Km = 41.423 μmol/L) LAT1. Aspartate was attached N-terminal DOX amide bond with free carboxyl and group α-carbon atom Asp residue. product Asp-DOX...
A xylose reductase (XR) with high activity and dual coenzyme from Candida tropical was purified to homogeneity by Ni2+-chelating column, immobilized on chitosan bead. Studies free XR systems for determination of optimum temperature, pH, thermal stability, pH operational kinetic parameters were carried out. Free showed higher at 45 50°C, respectively. The 4.5, but had a broader range 4.0-6.0. Thermal stability than that XR. residual was about 40% after 7 cycles batch operation. Km value 30.3...
Crucial light-controlled-ROS and pH-stimulus-responsive functionalities are tailored into a triblock copolymer for manufacture of gene delivery vehicles.
Circular RNAs (circRNAs) can function as competing endogenous (ceRNAs) to impact the development of esophageal squamous cell cancer (ESCC). Human circ_0001946 has been identified a potential anticancer factor in ESCC, yet our understanding its molecular basis remains limited.Circ_0001946, microRNA (miR)-1290 and SRY-box transcription 6 (SOX6) were quantified by quantitative reasl-time PCR (qRT-PCR) or immunoblotting. Cell proliferation was assessed CCK-8 EDU assays. apoptosis invasion...
Phomopsis longicolla, a causal agent of soybean root rot, stem blight, seed decay, pod and canker, which seriously affect the yield quality production worldwide. The phenylpyrrole fungicide fludioxonil exhibits broad spectrum high activity in controlling phytopathogenic fungi. In this study, 100 P. longicolla isolates collected from main areas China were used to establish baseline sensitivity fludioxonil, 12 fludioxonil-resistance (FluR) mutants generated 6 fludioxonil-sensitive (FluS)...
Addressing the uncontrolled spread and increase in antibiotic resistance methicillin-resistant <em>Staphylococcus aureus </em>(MRSA) will require new control strategies, particularly to improve safety of food. Our results revealed efficacy Theaflavin-3,3'-digallate (TFBG), which is a novel polyphenol derived from tea, targeting key regulatory protein MgrA <em>S. aureus</em>. Through fluorescence anisotropy, we showed that IC<sub>50</sub> TFBG was 26.76 μg/mL. uniquely counters aureus</em> by...
Background Esophagus cancer (EC) is an aggressive malignant in the world, and its progression involves regulation of circular RNA (circRNA). This study designed to reveal role circ_0008078 EC development underlying mechanism. Methods expression circ_0008078, miR-191-5p, ELOVL fatty acid elongase 4 (ELOVL4), cyclin D1, proliferating cell nuclear antigen (PCNA) was detected by qRT-PCR or Western blotting. Nuclear proliferation marker (Ki67) analyzed immunohistochemistry (IHC) assay. The...