Jennifer Cain
A5029344676- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Intelligence, Security, War Strategy
- Religion, Society, and Development
- Religious Education and Schools
- Biblical Studies and Interpretation
- ICT in Developing Communities
- Cancer-related gene regulation
- Religion, Ecology, and Ethics
- Media, Religion, Digital Communication
- Language, Linguistics, Cultural Analysis
- Research on Leishmaniasis Studies
- Biomedical Ethics and Regulation
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Developmental Biology and Gene Regulation
- Lung Cancer Treatments and Mutations
- Learning Styles and Cognitive Differences
- Experimental and Theoretical Physics Studies
- Mobile Learning in Education
- Web and Library Services
- Religious Tourism and Spaces
- Religion, Spirituality, and Psychology
- Open Education and E-Learning
- Sustainable Design and Development
Gilead Sciences (United States)
2022-2024
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2010
Abstract A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic DNA. Cancer cell...
<div>Abstract<p>A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic...
<p>Supplementary figureS2 shows the figures related to Figure 2.</p>
<p>Supplementary figureS1 shows the figures related to Figure 1.</p>
<p>Supplementary figureS3 shows the figures related to Figure 3.</p>
<p>Supplementary figureS4 shows the figures related to Figure 4.</p>
<p>Supplementary figureS4 shows the figures related to Figure 4.</p>
<div>Abstract<p>A substantial fraction of cancers evade immune detection by silencing Stimulator Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic reactivation this program via STING agonists, epigenetic, or DNA-damaging therapies can restore antitumor immunity in multiple preclinical models. Here we show that adaptive induction three prime exonuclease 1 (TREX1) restrains STING-dependent nucleic acid sensing cancer cells its catalytic function degrading cytosolic...
<p>Supplementary figureS2 shows the figures related to Figure 2.</p>
<p>Supplementary figureS3 shows the figures related to Figure 3.</p>
<p>Supplementary figureS1 shows the figures related to Figure 1.</p>