A5008863548- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Nutrition and Health in Aging
- SARS-CoV-2 and COVID-19 Research
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Soft tissue tumor case studies
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- COVID-19 Clinical Research Studies
- Pharmacogenetics and Drug Metabolism
- Renal Transplantation Outcomes and Treatments
- Glycosylation and Glycoproteins Research
- Cancer, Stress, Anesthesia, and Immune Response
- Infectious Disease Case Reports and Treatments
- Vascular Malformations and Hemangiomas
- Urinary Tract Infections Management
- Organ Donation and Transplantation
- Frailty in Older Adults
- IgG4-Related and Inflammatory Diseases
- Blood groups and transfusion
Hirosaki University
2017-2025
Penile metastases are rare, and metastasis of a gastrointestinal stromal tumor (GIST) to the penis is exceedingly uncommon. An 81-year-old man with history duodenal GIST, initially treated curative resection tyrosine kinase inhibitor therapy for liver metastasis, presented an enlarging penile mass. A biopsy confirmed from GIST. To relieve his symptoms, total penectomy was performed. Molecular testing revealed KIT exon 9 mutation CDKN2A/B gene alterations, indicating aggressive behavior...
We aimed to evaluate the seroprevalence and investigated factors associated with seropositivity after second SARS-CoV-2 mRNA vaccination in kidney transplant (KT) recipients. This retrospective study conducted between June November 2021 included 106 KT recipients 127 healthy controls who received dose of BNT162b2 vaccine at least 7 days before measurement antibody titers. The titer against receptor-binding domain spike (S) protein was determined. compared rates (immunoglobulin G [IgG] level...
The presence of glycosylated isoforms prostate-specific antigen (PSA) in prostate cancer (PC) cells is a potential marker their aggressiveness. We characterized the origin α2,3-sialylated (S23PSA) by tissue-based sialylation-related gene expression and studied performance S23PSA density (S23PSAD) alone combination with multiparametric magnetic resonance imaging (MRI) for detection clinically significant men elevated PSA.Tissue-based quantification sialyltransferase sialidase was evaluated 71...
Although aortic calcification has a significant negative impact on prognosis in patients hemodialysis (HD), risk factors for progression remain unclear. The aim of this study was to investigate the relationship between malnutrition and HD. Between April 2015 October 2016, we treated 232 Of those, retrospectively evaluated data from 184 who had regular blood tests computed tomography (CT) scans. abdominal index (ACI) quantitatively measured by CT. Nutritional status using Geriatric Risk Index...
Abstract Early diagnosis of urological diseases is often difficult due to the lack specific biomarkers. More powerful and less invasive biomarkers that can be used simultaneously identify could improve patient outcomes. The aim this study was evaluate a disease‐specific scoring system established with machine learning (ML) approach using Ig N ‐glycan signatures. Immunoglobulin signatures were analyzed by capillary electrophoresis from 1312 serum subjects hormone‐sensitive prostate cancer ( n...
To evaluate the impact of preoperative chronic kidney disease (CKD) on oncological outcomes in patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy.A total 426 nephroureterectomy at five medical centers between February 1995 and 2017 were retrospectively examined. Oncological outcomes, including intravesical recurrence-free, visceral cancer-specific, overall survival rates (intravesical RFS, CSS, OS, respectively) stratified by CKD status (CKD vs. non-CKD)...
The aim of this study was to analyze the features incidentally detected prostate cancer (PCa) in radical cystoprostatectomy (RCP) specimens determine their pathological characteristics and clinical significance.In retrospective study, we reviewed records 431 consecutive patients with muscle-invasive bladder who underwent RCP at Hirosaki University. Of these, focused on 237 male prostate-specific antigen (PSA) measurements digital rectal examinations (DRE) that were recorded prior RCP....
Abstract We aimed to evaluate the humoral response after second and third doses of SARS-CoV-2 mRNA vaccine in ABO blood type incompatible kidney transplant (KT) recipients treated with rituximab. This retrospective study conducted between June 2021 2022 included 131 KT 154 nontransplant controls who had received vaccines. compared seropositivity (anti-SARS-CoV-2 spike IgG antibody titer ≥ 0.8 U/mL) vaccinations. Furthermore, we evaluated impact pretransplant vaccination for seropositivity....
// Hirotaka Horiguchi 1 , Shingo Hatakeyama Go Anan 1, 2 Yuka Kubota Hirotake Kodama Masaki Momota Koichi Kido Hayato Yamamoto Yuki Tobisawa Tohru Yoneyama 3 Takahiro Yasuhiro Hashimoto Takuya Koie Hiroyuki Ito 4 Kazuaki Yoshikawa 5 Toshiaki Kawaguchi 6 Makoto Sato and Chikara Ohyama Department of Urology, Hirosaki University Graduate School Medicine, Hirosaki, Japan Tohoku Medical Pharmaceutical University, Sendai, Advanced Transplant Regenerative Aomori Rosai Hospital, Hachinohe, Mutsu...
A paratesticular fibrous pseudotumor is a relatively rare benign disease. Preoperatively diagnosing challenging because distinguishing these masses from malignant tumors on the basis of clinical and radiological findings can be difficult. We present case 28-year-old man who presented with painless palpable mass in right scrotum; tunica vaginalis was treated organ-sparing surgery. Computed tomography magnetic resonance imaging revealed tumors. Testicular tumor marker levels were within normal...
Abstract Discriminating between urothelial carcinoma (UC), including bladder cancer (BCa) and upper urinary tract UC (UTUC), is often challenging. Thus, the current study evaluated diagnostic performance of N ‐glycosylation signatures immunoglobulins (Igs) for detecting UC, BCa UTUC. Igs from serum samples training cohort, 104 BCa, 68 UTUC, 10 infection, 5 cystitis cases, as well 62 healthy volunteers, were measured retrospectively using automated capillary‐electrophoresis‐based ‐glycomics....
Abstract We aimed to determine the survival and staging benefit of limited pelvic lymph node dissection (PLND) during radical prostatectomy (RP) in high-risk prostate cancer (PC) patients treated with neoadjuvant chemohormonal therapy. retrospectively analyzed 516 localized PC (< cT4N0M0) who received androgen-deprivation therapy plus estramustine phosphate followed by RP between January 2010 March 2020. Since we stopped PLND for such October 2015, compared surgical outcomes biochemical...
428 Background: The prognostic benefit of oncological follow-up to detect asymptomatic recurrence after radical cystectomy (RC) remains unclear. We aimed assess whether routine RC improves patient survival. Methods: retrospectively analyzed 581 cases for muscle invasive bladder cancer at four hospitals between May 1996 and February 2017. All patients had regular examinations with urine cytology, blood biochemical tests, computed tomography RC. investigated the first site date tumor...
486 Background: Systemic inflammation is a common host reaction to cancer progression. Serum level of buttyrylcholinesterase (BChE) have been reported reflect the presence and other clinical conditions. BChE an alphaglycoprotein found in nervous system liver. Its serum reduced many conditions, such as liver damage, injury, infection, malignant disease. We retrospectively evaluated potential prognostic significance before chemotherapy independent predictor overall survival patients with...