A5101637314- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Ureteral procedures and complications
- Hippo pathway signaling and YAP/TAZ
- Lower Extremity Biomechanics and Pathologies
- Multiple Myeloma Research and Treatments
- Renal and Vascular Pathologies
- Peroxisome Proliferator-Activated Receptors
- Advanced MRI Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Urological Disorders and Treatments
- Hormonal and reproductive studies
- Osteoarthritis Treatment and Mechanisms
- Acute Kidney Injury Research
- Hormonal Regulation and Hypertension
- Sexual function and dysfunction studies
- Bone and Joint Diseases
- Uterine Myomas and Treatments
- Scoliosis diagnosis and treatment
- RNA modifications and cancer
- Adrenal and Paraganglionic Tumors
- Cancer-related molecular mechanisms research
- Tendon Structure and Treatment
Akita University
2002-2024
Miyagi Prefectural Hospital Organization
2020
Meikai University
2017
Tsurumi University
2017
Niigata University
2012
Gifu University
2004
Tohoku University
1986
Shizuoka Children's Hospital
1985
Objectives To evaluate the association of tumor burden with prognosis in real‐world patients metastatic castration‐sensitive prostate cancer and to investigate eligibility for upfront intensification therapy. Methods We retrospectively evaluated 679 who were initially treated conventional androgen deprivation therapy between August 2001 November 2018. The primary purpose was based on progression castration‐resistant cancer. secondary included comparison rate, cancer‐free survival overall...
Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets enriched in saturated monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression weight gain compared fish oil (FOD). High gut microbial divergency resulted from difference diets, the abundance of several bacterial species, such as orders Clostridiales Lactobacillales, was markedly altered feces LD- or FOD-fed...
Abstract We evaluated the impact of early changes in serum biomarker levels on survival patients with metastatic hormone-sensitive prostate cancer (mHSPC) who were initially treated androgen deprivation therapy (ADT). retrospectively investigated 330 mHSPC whose maker at baseline and 2–4 months. An optimal Cox regression model was established highest optimism-corrected concordance index based 10-fold cross-validation. The median cancer-specific (CSS) overall (OS) 7.08 6.47 years (median...
Abstract Background Although docetaxel-based chemohormonal therapy (CHT) is one of the standard treatments for castration-resistant prostate cancer (CRPC), pertinent biomarkers and precise mechanisms involved in resistance CHT CRPC remain unknown. We investigated relationship between expression steroid receptors Hippo pathway proteins using a docetaxel-resistant (PCa) cell line human PCa tissues patients who underwent surgery with without neoadjuvant therapy. Methods A subline (22Rv1-DR) was...
Less evidence is known about the role of early changes in serum biomarker after androgen deprivation therapy (ADT) patients with metastatic hormone-sensitive prostate cancer (mHSPC). Here we evaluated impact pre-treatment prognostic factors and biomarkers on specific antigen (PSA) progression-free overall survival rates mHSPC. We retrospectively reviewed medical records 60 mHSPC (median age 72 years) treated ADT whose laboratory data at baseline following 12 weeks were available. Forty-four...
Abstract Background This study assessed the incidence and impact of acute kidney injury (AKI) on renal prognosis in patients who underwent robot‐assisted laparoscopic radical prostatectomy (RARP). Methods Medical records 305 treated with RARP were retrospectively reviewed. The postoperative AKIs dichotomized into early AKI (immediately after surgery) late (1‐7 days surgery). their risk factors statistically assessed. Results Early observed 143 (46.9%) 12 (3.9%) patients, respectively....
Abstract The metabolic reprogramming of phospholipids may affect intracellular signal transduction pathways. A high‐fat diet (HFD) is attributed to prostate cancer (PCa) progression, but the expression pattern and role in HFD‐mediated PCa progression remains unclear. In this study, HFD enhanced LNCaP xenograft tumor growth by upregulating phosphatidylinositol (PI) 3‐kinase (PI3K)/AKT signaling pathway. lipidomic analysis using tumors showed that phosphoinositides, especially PI...
Abstract Background The purpose of this study was to identify predictive factors associated with conditional net survival in patients metastatic hormone‐naive prostate cancer (mHNPC) initially treated androgen deprivation therapy (ADT). Methods At nine hospitals Tohoku, Japan, the medical records 605 consecutive mHNPC who received ADT were retrospectively reviewed. Pohar Perme estimator used calculate cancer‐specific (CSS) and overall (OS) for up 5 years subsequent diagnosis. Using multiple...
Arterio-ureteral fistulas (AUFs), which are relatively rare but potentially life-threatening, require prompt diagnosis and treatment. We reported a case of AUFs following robot-assisted laparoscopic radical cystectomy (RARC) with extended pelvic lymph node dissection ileal conduit urinary diversion for muscle-invasive bladder cancer, resulted in massive hemorrhage. Urine leaked from the anastomosis between ureter, end was infected, an AUF pseudoaneurysm right common iliac artery ureter. The...